Summary
Rats lesioned shortly after birth with 6-hydroxydopamine are posed as a near-ideal model of severe Parkinson’s disease, because of the non-lethality of the procedure, near-total destruction of nigrostriatal dopaminergic fibers, near-total dopamine (DA)-denervation of striatum, reproducibility of effect, and relative absence of overt behavioral effects – there is no aphasia, no adipsia, and no change in motor activity. In vivo microdialysis findings reinforce the utility of the animal model, clearly demonstrating L-DOPA beneficial actions without an increase in hydroxyl radical production.
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Keywords
- Stereotyped Activity
- Dopaminergic Innervation
- Nigrostriatal Dopaminergic Tract
- Johnson City
- Selective Neurotoxin
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© 2006 Springer-Verlag
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Kostrzewa, R.M., Kostrzewa, J.P., Brus, R., Kostrzewa, R.A., Nowak, P. (2006). Proposed animal model of severe Parkinson’s disease: neonatal 6-hydroxydopamine lesion of dopaminergic innervation of striatum. In: Riederer, P., Reichmann, H., Youdim, M.B.H., Gerlach, M. (eds) Parkinson’s Disease and Related Disorders. Journal of Neural Transmission. Supplementa, vol 70. Springer, Vienna . https://doi.org/10.1007/978-3-211-45295-0_43
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DOI: https://doi.org/10.1007/978-3-211-45295-0_43
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