Summary
The long-term effects of rehabilitated infancy (1 year old) iron deficiency (ID) were examined at age 10. The children were examined for the following variables: auditory system function, the level of morning cortisol, I.Q. score (WISC-R), and behavioral profile. The results indicate that while the former ID children’s hearing system appears to function well, there was a delay in brain stem processing of the auditory signals. In addition, the level of morning cortisol was reduced, the general I.Q. scores were lower than the normal group (mainly in the performed subtest), and more sleep disturbances and fatigue during day were reported. These outcomes are consistent with established reports on the effect of iron deficiency on the rate of myelination in selected brain areas during critical period of 1 year olds. The findings of increased sleep disturbances and lower I.Q. tests require further study.
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Keywords
- Salivary Cortisol
- Auditory Brainstem Response
- Morning Cortisol
- Audiometric Test
- Brain Research Institute
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References
Algarin C, Peirano P, Garrido M, Pizarro F, Lozoff B (2003) Iron deficiency anemia in infancy: long-lasting effects on auditory and visual system functioning. Pediatr Res 51: 1–7
Backhaus J, Junghanns K, Hohagen F (2004) Sleep disturbances are correlated with decreased morning awakening salivary cortisol. Psychoendocrinology 29: 1184–1191
Beard J, Borel M, Peterson FJ (1997) Changes in iron status during weight loss with very-slow-energy diets. Am J Clin Nutr 66: 104–110
Ben-Shachar D, Ashkenazi R, Youdim MB (1986) Long-term consequence of early iron-deficiency on dopaminergic neurotransmission in rats. Int J Dev Neurosci 4: 81–88
Buzina SK, Buzina R, Stavljenic A, Farley TM, Haller J, Bergman M, Gorajscan M (1998) Aging, nutritional status and immune response. Int Vitm Nutr Res 68: 133–141
Kariyawasam SH, Zaw F, Handley SL (2002) Reduced salivary cortisol in children with comorbid attention deficit hyperactivity disorder and oppositional defiant disorder. Neuro Endocrinol Lett 23: 45–48
King JA, Barkley RA, Barrett S (1997) Attention-deficit hyperactivity disorder and the stress response. Biol Psychiatry 44: 72–74
Lozoff B, Jimenez E, Hagen J, Mollen E, Wolf AW (2000) Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics 105: E51–E84
Lozoff B, Wolf AW, Jimenez E (1996) Effects of extended oral iron therapy. J Pediatr 129: 382–389
Roncagliolo M, Garrido M, Walter T, Peirano P, Lozoff B (1998) Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 months. Delayed maturation of auditory brainstem responses. Am J Clin Nutr 68: 683–690
Saad MJ, Morais SL, Saad ST (1991) Reduced cortisol secretion in patients with iron deficiency. Ann Nutr Metabol 35: 111–115
Scrimshaw NS (1991) Iron deficiency. Sci Am 265: 24–30
Scrimshaw NS (1998) Malnutrition, brain development learning and behavior. Nutr Res 18: 351–379
Scrimshaw NS, SanGiovanni JP (1997) Synergism of nutrition, infection and immunity. Am J Clin Nutr 66: 464S–477S
Sun AH, Wang ZM, Xiao SZ, Li ZJ, Liang ZF, Hu GY, Ye XT (1991) Noiseinduced hearing loss in iron-deficient rats. Acta Otolaryngol 111: 684–690
Weinberg J, Brett LP, Levine S, Dallman PR (1981) Long-term effects of early iron deficiency on consummately behavior in the rat. Pharmacol Biochem Behav 14: 447–453
Youdim MB, Yehuda S (2000) The neurochemical basis of cognitive deficits induced by brain iron deficiency: involvement of dopamineopiate system. Cell Mol Biol 46: 491–500
Youdim MBH, Ben-Shachar D, Yehuda S (1989) Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior. Am J Clin Nutr 50: 607–617
Youdim MBH, Yehuda S (2000) The neurochemical basis of cognitive deficits induced by brain iron deficiency: involvement of dopamineopiate system. Cell Mol Biol 46: 491–500
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Yehuda, S., Yehuda, M. (2006). Long lasting effects of infancy iron deficiency — Preliminary results. In: Parvez, H., Riederer, P. (eds) Oxidative Stress and Neuroprotection. Journal of Neural Transmission. Supplementa, vol 71. Springer, Vienna. https://doi.org/10.1007/978-3-211-33328-0_20
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DOI: https://doi.org/10.1007/978-3-211-33328-0_20
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