Summary
5-Hydroxytryptamine (5-Ht) causes a variety of effects on human heart through several 5-HT receptor subtypes. Both 5-HT1 -like receptors and 5-HT2 receptors in large coronary arteries mediate spasm. It is likely that vagal 5-HT3 receptors mediate reflex bradycardia while sinoatrial 5-HT4-like receptors mediate tachycardia. Right atrial 5-HT4-like receptors mediate increases in contractile force and relaxation through a cyclic AMP-dependent pathway.
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© 1991 Birkhäuser Verlag Basel/Switzerland
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Kaumann, A.J. (1991). 5-Hydroxytryptamine and the Human Heart. In: Fozard, J.R., Saxena, P.R. (eds) Serotonin: Molecular Biology, Receptors and Functional Effects. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7259-1_35
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DOI: https://doi.org/10.1007/978-3-0348-7259-1_35
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-7261-4
Online ISBN: 978-3-0348-7259-1
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