Abstract
This chapter provides an introduction to and overview of peptide chemistry with a focus on solid-phase peptide synthesis. The background, the most common reagents, and some mechanisms are presented. This chapter also points to the different chapters and puts them into perspective.
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Abbreviations
- Acm:
-
Acetamidomethyl
- BAL:
-
Backbone Amide Linker
- Boc:
-
Tert-butyloxycarbonyl
- BOP:
-
Benzotriazol-1-yl-N-oxy-tris(dimethylamino)phosphonium hexafluorophosphate
- Cbz:
-
Benzyloxycarbonyl
- COMU:
-
(1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino-methylene)] methanaminium hexafluorophosphate)
- DIC:
-
N,N′-Diisopropylcarbodiimide
- DIEA:
-
N,N-Diisopropylethylamine
- DMF:
-
N,N-Dimethylformamide
- Fmoc:
-
Fluoren-9-ylmethyloxycarbonyl
- HATU:
-
(N-[(Dimethylamino)-1H-1,2,3-triazole[4,5-b]pyridine-1-ylmethylene]-N-methyl- methanaminium hexafluorophosphate N-oxide)
- HBTU:
-
(N-[(1H-Benzotriazol-1-yl)(dimethylamino)methylene]-N-methylmethan- aminium hexafluorophosphate N-oxide)
- HOBt:
-
1-hydroxybenzotriazole
- HOAt:
-
3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridine [1-hydroxy-7-azabenzotriazole
- NHS:
-
N-Hydroxysuccinimide
- NMP:
-
N-Methyl-2-pyrrolidinone
- Pbf:
-
2,2,4,6,7-Pentamethyl-dihydrobenzofuran-5-sulfonyl
- Pfp:
-
Pentafluorophenyl
- PyBOP:
-
(1-benzotriazolyloxy-tris-pyrrolidinophosphonium hexafluorophosphate)
- TFA:
-
Trifluoroacetic acid
- TFMSA:
-
Trifluoromethanesulfonic acid
- Trt:
-
Trityl (triphenylmethyl)
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Jensen, K.J. (2013). Solid-Phase Peptide Synthesis: An Introduction. In: Jensen, K., Tofteng Shelton, P., Pedersen, S. (eds) Peptide Synthesis and Applications. Methods in Molecular Biology, vol 1047. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-544-6_1
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