Abstract
Oral cancer diagnosis can be greatly facilitated by early diagnosis in order to improve the 50 % 5-year mortality that has not changed much over the last years. Saliva is an easily accessible medium that has been shown to contain microvesicles (exosomes) that enclose microRNAs. We have previously demonstrated that the majority of salivary microRNAs are within exosomes. MicroRNAs have been implicated in oral cancer and the use of salivary exosomal microRNAs holds the promise of identification of diagnostic and prognostic markers.
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Acknowledgements
This research was supported by the Intramural Research Program of the National Institute of Dental and Craniofacial Research.
We would like to thank Dr. Gabor Illei for his intellectual contributions and Lolita Bebris, Tammy Yokum, and Dr. Margaret Grissius for the optimization of the saliva collection.
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Gallo, A., Alevizos, I. (2013). Isolation of Circulating MicroRNA in Saliva. In: Kosaka, N. (eds) Circulating MicroRNAs. Methods in Molecular Biology, vol 1024. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-453-1_14
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DOI: https://doi.org/10.1007/978-1-62703-453-1_14
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-452-4
Online ISBN: 978-1-62703-453-1
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