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MicroRNAs in Skin and Wound Healing

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MicroRNA Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 936))

Abstract

MicroRNAs (miRNAs) are small noncoding RNA molecules ∼22 nucleotides in length that can post-transcriptionally repress gene expression. MiRNAs bind to their target messenger RNAs (mRNAs), leading to mRNA degradation or suppression of translation. miRNAs have recently been shown to play pivotal roles in skin development and are linked to various skin pathologies, cancer, and wound healing. Chronic wounds represent a major health burden and drain on resources and developing more effective treatments is therefore a necessity. Increase in the understanding of the regulation of chronic wound biology is therefore required to develop newer therapies. This review focuses on the role of miRNAs in cutaneous biology, the various methods of miRNA modulation, and the therapeutic opportunities in treatment of skin diseases and wound healing.

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Acknowledgments

Wound healing research in the author’s laboratory is funded by NIH awards GM 077185 and GM 069589 to CK Sen.

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Authors and Affiliations

  1. Department of Surgery, Ohio State University Medical Center, Columbus, OH, USA

    Jaideep Banerjee & Chandan K. Sen

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  1. Jaideep Banerjee
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  2. Chandan K. Sen
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Corresponding author

Correspondence to Chandan K. Sen .

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Editors and Affiliations

  1. Keck School of Medicine, Dept. of Cell and Neurobiology, University of Southern California, San Pablo St. 1333, Los Angeles, 90033, California, USA

    Shao-Yao Ying

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Banerjee, J., Sen, C.K. (2013). MicroRNAs in Skin and Wound Healing. In: Ying, SY. (eds) MicroRNA Protocols. Methods in Molecular Biology, vol 936. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-083-0_26

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  • DOI: https://doi.org/10.1007/978-1-62703-083-0_26

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-082-3

  • Online ISBN: 978-1-62703-083-0

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