Abstract
The future success of translational research is critically dependent on the procurement and availability of high-quality tissue specimens linked to accurate histopathologic and clinical information about the individual banked specimen. The international community has awakened to this critical need only recently. Three major roadblocks have hindered the success of previous biobank consortiums: (1) Ethical issues surrounding patient consent and ownership of intellectual property, (2) Failure to properly preserve the molecular content of the tissue, and failure to reliably document clinical data linked to the specimen, and (3) Management issues: inadequate funding, competition for use of the tissue, inadequate personnel and facilities, and absence of dedicated database software. This chapter reviews these critical roadblocks and discusses international efforts to provide strategies to implement high-quality biobanks.
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References
Robb, J. (2010) 2010 Revised NCI Best Practices for Biospecimen Resources. National Cancer Institute: Bethesda, MD.
Pitt, K. E. (2008) 2008 Best Practices for Repositories: Collection, Storage, retrieval and Distribution of Biological Materials for Research. Cell Preservation Technology 6, 3–58.
Poste, G. (2011) Bring on the biomarkers. Nature 469, 156–7.
Lim, M. D., Dickherber, A., Compton, C. C. (2011) Before you analyze a human specimen, think quality, variability, and bias. Anal Chem 83, 8–13.
Park, A. (2009) 10 Ideas Changing the World Right Now - Biobanks. TIME, Inc. Thursday March 12.
Mager, S. R., Oomen, M. H., Morente, M. M., Ratcliffe, C., Knox, K., Kerr, D. J. et al. (2007) Standard operating procedure for the collection of fresh frozen tissue samples. Eur J Cancer 43, 828–34.
Morente, M. M. (2011) Tumour Bank: The CNIO Tumour Bank Network. 2011. Spanish National Cancer Research Centre, http://www.cnio.es/ing/index.asp.
Riegman, P. H., Bosch, A. L. (2008) OECI TuBaFrost tumor biobanking. Tumori 94, 160–3.
Sebire, N. J., Dixon-Woods, M. (2007) Towards a new era of tissue-based diagnosis and research. Chronic Illn 3, 301–9.
Editorial (2006) The advocates. Nat Genet 38, 391.
Terry, S. F., Terry, P. F., Rauen, K. A., Uitto, J., Bercovitch, L. G. (2007) Advocacy groups as research organizations: the PXE International example. Nat Rev Genet 8, 157–64.
Eiseman, E., Bloom, G., Brower, J., Clancy, N., Olmsted, S. S. Case Studies of Existing Human Tissue Repositories: “Best Practices” for a Biospecimen Resource for the Genomic and Proteomic Era, RAND Corporation, Santa Monica, CA, 2003.
Qualman, S. J., France, M., Grizzle, W. E., LiVolsi, V. A., Moskaluk, C. A., Ramirez, N. C. et al. (2004) Establishing a tumour bank: banking, informatics and ethics. Br J Cancer 90, 1115–9.
Grizzle, W. E., Aamodt, R., Clausen, K., LiVolsi, V., Pretlow, T. G., Qualman, S. (1998) Providing human tissues for research: how to establish a program. Arch Pathol Lab Med 122, 1065–76.
Becich, M. J. (2000) The role of the pathologist as tissue refiner and data miner: the impact of functional genomics on the modern pathology laboratory and the critical roles of pathology informatics and bioinformatics. Mol Diagn 5, 287–99.
(2004) AB v Leeds Teaching Hospital NHS Trust. Fam Law Rep 2, 365–439.
Quigley, M. (2009) Property: The Future Of Human Tissue? 10.1093/medlaw/fwp021 Medical Law Review 17 457–466.
Various (1998 Summer) Commentary. 10.1093/medlaw/6.2.247. Medical Law Review 6, 247–261.
Matthews, P. (1995) The Man Of Property. 10.1093/medlaw/3.3.251. Medical Law Review 3, 251–274.
Price, D. (2011 Spring) From Cosmos and Damian to Van Velzen: The Human Tissue Saga Continues. 10.1093/medlaw/11.1.1. Medical Law Review 11, 1–47.
Nwabueze, R. N. (2008) Donated Organs, Property Rights And The Remedial Quagmire. 10.1093/medlaw/fwn004 Medical Law Review 16 201–224
Glantz, L., Roche, P., Annas, G. J. (2008) Rules for donations to tissue banks--what next? N Engl J Med 358, 298–303.
Knoppers, B. M. (2005) Consent revisited: points to consider. Health Law Rev 13, 33–8.
Clayton, E. W. (2005) Informed consent and biobanks. J Law Med Ethics 33, 15–21.
Knoppers, B. M. (2005) Biobanking: international norms. J Law Med Ethics 33, 7–14.
Knoppers, B. M., Hirtle, M., Lormeau, S., Laberge, C. M., Laflamme, M. (1998) HUGO Ethics Committee Statement on DNA sampling: control and access. Genetic Resour 11, 43–4.
(2002) International ethical guidelines for biomedical research involving human subjects. Bull Med Ethics 17–23.
(2003) [The UNESCO international declaration about human genetic data]. Law Hum Genome Rev 239–53.
Simitis, S. (2004) Biobaken fur die Forschung. Nationaler Ethikrat: Hamburg.
HGC (2002) Inside information:Balancing interests in the use of personal genetic data. Human Genetics Commission: London, 183.
Kaye, J., Helgason, H. H., Nomper, A., Sild, T., Wendel, L. (2004) Population genetic databases: a comparative analysis of the law in Iceland, Sweden, Estonia and the UK. TRAMES 8, 15–33.
Bale, M. (2009) Key principles relating to genetic testing and insurance. Law Hum Genome Rev 203–7.
(2004) Draft additional protocol to the Convention on Human Rights and Biomedicine, on biomedical research. J Int Bioethique 15, 107–22.
Doppelfeld, E. (2002) Good medical research--the view of the CDBI/Council of Europe. Sci Eng Ethics 8, 283–6.
Elger, B. S., Caplan, A. L. (2006) Consent and anonymization in research involving biobanks: differing terms and norms present serious barriers to an international framework. EMBO Rep 7, 661–6.
Meslin, E. M. (1999) The National Bioethics Advisory Commission (NBAC) report. Biol Psychiatry 46, 1011–2.
Crigger, B. J. (2001) National Bioethics Advisory Commission Report: Ethical and policy issues in international research. Irb 23, 9–12.
Childress, J. F. (1998) The National Bioethics Advisory Commission: bridging the gaps in human subjects research protection. J Health Care Law Policy 1, 105–22.
(2008) OHRP - Guidance on Research Involving Coded Private Information or Biological Specimens. US Department of Health and Human Services, Office of Human Research Protection: Bethesda, MD
Wendler, D. (2006) One-time general consent for research on biological samples: is it compatible with the health insurance portability and accountability act? Arch Intern Med 166, 1449–52.
Kettis-Lindblad, A., Ring, L., Viberth, E., Hansson, M. G. (2007) Perceptions of potential donors in the Swedish public towards information and consent procedures in relation to use of human tissue samples in biobanks: a population-based study. Scand J Public Health 35, 148–56.
Borisch, B. (2007) Tissue banking in a regulated environment--does this help the patient? Part 2--Patient views and expectations (including the EUROPA DONNA Forum UK position). Pathobiology 74, 223–6.
Morrin, H., Gunningham, S., Currie, M., Dachs, G., Fox, S., Robinson, B. (2005) The Christchurch Tissue Bank to support cancer research. N Z Med J 118, U1735.
Cousins, G., McGee, H., Ring, L., Conroy, R., Kay, E., Croke, D. T. et al. (2005) Public perceptions of biomedical research: a survey of the general population in Ireland., Health Research Board: Dublin
Espina, V., Edmiston, K. H., Heiby, M., Pierobon, M., Sciro, M., Merritt, B. et al. (2008) A portrait of tissue phosphoprotein stability in the clinical tissue procurement process. Mol Cell Proteomics 7, 1998–2018.
Patel, A. A., Gilbertson, J. R., Parwani, A. V., Dhir, R., Datta, M. W., Gupta, R. et al. (2006) An informatics model for tissue banks--lessons learned from the Cooperative Prostate Cancer Tissue Resource. BMC Cancer 6, 120.
Dixon-Woods, M., Wilson, D., Jackson, C., Cavers, D., Pritchard-Jones, K. (2008) Human Tissue and the Public: The Case of Childhood Cancer Tumour Banking. BioSocieties 3, 57–80.
Wilan, K. (2007) From bench to business and back again. Cell 131, 211–3.
Burgess, M. M., O’Doherty, K. C., Secko, D. M. (2009) Biobanking in British Columbia: discussions of the future of personalized medicine through deliberative public engagement. Per Med 5, 285–296.
O’Doherty, K. C., Burgess, M. M. (2009) Engaging the public on biobanks: outcomes of the BC biobank deliberation. Public Health Genomics 12, 203–15.
Imbeaud, S., Auffray, C. (2005) ‘The 39 steps’ in gene expression profiling: critical issues and proposed best practices for microarray experiments. Drug Discov Today 10, 1175–82.
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Gaffney, E.F., Madden, D., Thomas, G.A. (2012). The Human Side of Cancer Biobanking. In: Espina, V., Liotta, L. (eds) Molecular Profiling. Methods in Molecular Biology, vol 823. Humana Press. https://doi.org/10.1007/978-1-60327-216-2_5
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