Hallmarks of traumatic brain injury in man can be faithfully reproduced in the laboratory using fluid percussion injury. Variations in the surgical procedure provide the ability to induce focal diffuse or mixed focal and diffuse brain injury in various laboratory species. Being fully scalable, fluid percussion can induce mild, moderate, or severe brain injury in subjects of any age. This chapter outlines the procedures for midline (diffuse) fluid percussion brain injury in adult male Sprague-Dawley rats and lateral (mixed) fluid percussion brain injury in adult male mice. With these procedures, it becomes possible to generate brain-injured laboratory animals for studies of injury-induced pathophysiology and behavioral deficits, for which rational therapeutic interventions can be implemented.
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Lifshitz, J. (2009). Fluid Percussion Injury Model. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_32
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DOI: https://doi.org/10.1007/978-1-60327-185-1_32
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