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DNA Repair in Bacteriophage

  • Chapter
DNA Damage and Repair

Part of the book series: Contemporary Cancer Research ((CCR))

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Abstract

Starting with the very first studies on DNA repair in 1947, most of the earliest work, involving recombinational repair, photoreactivation, and excision repair, were carried out with bacteriophage (phage) T4 (reviewed in 4,6). Repair processes in phage appear to be similar to DNA repair processes in other organsims, and genes necessary for DNA repair in phage, such as phage T4 genes denV and uvsX, are homologous to repair genes in bacteria and eucaryotes (see Sub heading 7.). Thus, study of DNA repair processes in phage illuminates the mechanisms and adaptive functions of similar, but often more complex, processes in bacteria and eucaryotes.

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  1. Carol Bernstein
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  2. Harris Bernstein
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  1. Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA

    Jac A. Nickoloff

  2. Qbiogene, Carlsbad, CA, USA

    Merl F. Hoekstra

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Bernstein, C., Bernstein, H. (2001). DNA Repair in Bacteriophage. In: Nickoloff, J.A., Hoekstra, M.F. (eds) DNA Damage and Repair. Contemporary Cancer Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-095-7_1

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