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Sonoporation for Augmenting Chemotherapy of Pancreatic Ductal Adenocarcinoma

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Drug Delivery Systems

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2059))

Abstract

Pancreatic cancer is the third most common cancer diagnosed in the United States, with more than 53,000 new cases in 2017. It is the fourth leading cause of cancer-related death in both men and women. Nonetheless, there has been no significant improvement in survival for pancreatic ductal adenocarcinoma (PDAC) patients over the past 30+ years. For this reason, there is a considerable and urgent clinical need to develop innovative strategies for effective drug delivery and treatment monitoring, resulting in improved outcomes for patients with PDAC.

This chapter describes the development of contrast-enhanced ultrasound image-guided drug delivery (CEUS-IGDD or sonoporation) to be that method and to translate it from the lab to the clinic. The initial clinical focus has been on a Phase I clinical trial for enhancing the effectiveness of standard chemotherapeutics for treatment of inoperable PDAC, which demonstrated a median survival increase from 8.9 months to 17.6 months in ten subjects augmented with sonoporation compared to 63 historical controls (p = 0.011). Recent efforts to optimize this platform and move forward to a larger Phase II clinical trial will be described.

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Author information

Authors and Affiliations

  1. General Electric Research, Niskayuna, NY, USA

    Jason Castle

  2. National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway

    Spiros Kotopoulis

  3. Thomas Jefferson University, Philadelphia, PA, USA

    Flemming Forsberg

Authors
  1. Jason Castle
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  2. Spiros Kotopoulis
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  3. Flemming Forsberg
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Corresponding author

Correspondence to Jason Castle .

Editor information

Editors and Affiliations

  1. Jain PharmaBiotech, Basel, Switzerland

    Kewal K. Jain

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Castle, J., Kotopoulis, S., Forsberg, F. (2020). Sonoporation for Augmenting Chemotherapy of Pancreatic Ductal Adenocarcinoma. In: Jain, K. (eds) Drug Delivery Systems. Methods in Molecular Biology, vol 2059. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9798-5_9

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  • DOI: https://doi.org/10.1007/978-1-4939-9798-5_9

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9797-8

  • Online ISBN: 978-1-4939-9798-5

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