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Network-Based Drug Repositioning: Approaches, Resources, and Research Directions

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Computational Methods for Drug Repurposing

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1903))

Abstract

The wealth of knowledge and omic data available in drug research allowed the rising of several computational methods in drug discovery field yielding a novel and exciting application called drug repositioning. Several computational methods try to make a high-level integration of all the knowledge in order to discover unknown mechanisms. In this chapter we present an in-depth review of data resources and computational models for drug repositioning.

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Acknowledgments

This work has been done within the research project “Marcatori molecolari e clinico-strumentali precoci, nelle patologie metaboliche e cronico-degenerative” founded by the Department of Clinical and Experimental Medicine of University of Catania.

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

    Salvatore Alaimo & Alfredo Pulvirenti

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  1. Salvatore Alaimo
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  2. Alfredo Pulvirenti
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Corresponding author

Correspondence to Alfredo Pulvirenti .

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Editors and Affiliations

  1. Insilico Medicine, Inc., Rockville, MD, USA

    Quentin Vanhaelen

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Alaimo, S., Pulvirenti, A. (2019). Network-Based Drug Repositioning: Approaches, Resources, and Research Directions. In: Vanhaelen, Q. (eds) Computational Methods for Drug Repurposing. Methods in Molecular Biology, vol 1903. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8955-3_6

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  • DOI: https://doi.org/10.1007/978-1-4939-8955-3_6

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8954-6

  • Online ISBN: 978-1-4939-8955-3

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