Abstract
Herpes simplex virus type 1 (HSV-1) is a common and important human pathogen that has been studied in a wide variety of contexts for several decades. This book presents chapters on protocols on many strands of HSV-1 research that are currently in use in leading laboratories. This chapter gives a brief overview of HSV-1 biology and life cycle, covering basic aspects of the virus and its replication in cultured cells, the diseases caused by the virus, viral latency, antiviral defenses, and the mechanisms that the virus uses to counteract these defenses.
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Acknowledgements
The work in the author’s laboratory is funded by the Medical Research Council. The author is very grateful for the image provided by Dr. Frazer Rixon that is presented in Fig. 1a.
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Everett, R.D. (2014). HSV-1 Biology and Life Cycle. In: Diefenbach, R., Fraefel, C. (eds) Herpes Simplex Virus. Methods in Molecular Biology, vol 1144. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0428-0_1
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DOI: https://doi.org/10.1007/978-1-4939-0428-0_1
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