Abstract
Polymorphonuclear leukocytes (PMN) are the initial cells recruited to the site of inflammation where foreign invaders such as microorganisms, toxic gases and chemicals elicit an inflammation reaction4,6,12. Activated PMN produce various oxygen and hydroxyl radicals which kill bacteria and fungi but may also induce indiscriminate cellular damage14. For example, HOCl/OCl- produced by the halide-dependent myeloperoxidase of PMN is highly toxic. Taurine attenuates the damage caused by HOCl/OCl- by forming taurine chloramine (Tau-Cl), a relatively non-toxic and long-lived oxidant7,9,13,15. Previously we demonstrated that Tau-Cl suppressed the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) in activated murine peritoneal macrophages and/or RAW 264.7, a murine macrophage cell line8,10,11. Tau-Cl also inhibits the production of superoxide anion in activated murine peritoneal PMN5. Since human PMN produce Tau-Cl by halide-dependent myeloperoxidase, we investigated the effect of Tau-Cl on the production of various cytokines and superoxide anion by activated human PMN. In this report we demonstrate that Tau-Cl down-regulates the production of superoxide anion, IL-6 and IL-8 by activated human PMN.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Gordon, R.E., Shaked, A.A., and Solano, D.F., 1986, Taurine protects hamster bronchioles from acute NO2-induced alterations, a histologie, ultrastructural and freeze-fracture study, Am. J. Pathol., 125:585–600.
Green T., Fellman, J.H., Eicher, A.I., and Pratt, K.J., 1991, Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils, Biochem. Biophys. Acta., 1073:93–97.
Gurujeyalakshmi, G., Iyer, S.N., Hollinger, M.A., and Geri, S.N., 1996, Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin model of lung fibrosis, J. Pharmacol. Exp. Ther., 277:1152–1157.
Harada, A., Sekido, N., Akahoshi, T., Wada, T., Mukaida, N., and Matsushima, K., 1994, Essential involvement of interleukin-8 (IL-8) in acute inflammation, J. Leukoc. Biol., 56:559–564.
Kim, C., Park, E., Quinn, M.R., and Schuller-Levis, G., 1996, The production of Superoxide anion and nitric oxide by cultured murine leukocytes and the accumulation of TNF-α in the conditioned media is inhibited by taurine chloramine, Immunopharmacology 34:89–95.
Lloyd, A. and Oppenheim, J., 1992, Poly’s lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response, Immunology Today, 13:169–172.
Marques, L.A. and Dunford, H.B., Chlorination of taurine by myeloperoxidase: kinetic evidence for an enzyme-bound intermediate, J. Biol. Chem., 269:7950-7956.
Park, E., Quinn, M.R., Wright, C.E., and Schuller-Levis, G., 1993, Taurine chloramine inhibits the synthesis of nitric oxide and release of tumor necrosis factor in activated RAW 264.7 cells, J. Leukoc. Biol., 54:119–124.
Park, E., Schuller-Levis, G., Jia, J., and Quinn, M.R., 1997, Preactivation exposure of RAW 264.7 cells to taurine chloramine attenuates subsequent production of nitric oxide and expression of iNOS mRNA, J. Leukoc. Biol., 61:161–166.
Park, E., Schuller-Levis, G., and Quinn, M.R., 1995, Taurine chloramine inhibits production of nitric oxide and TNF-α in activated RAW 264.7 cells by mechanisms that involve transcriptional and translational events, J. Immunol., 154:4778–4784.
Quinn, M.R., Park, E., and Schuller-Levis, G., 1996, Taurine chloramine inhibits prostaglandin E2 production in activated RAW 264.7 cells by post-transcriptional effects on inducible cyclooxygenase expression, Immunol. Lett., 50:185–188.
Schleimer, R., Freeland, H., Peter, S., Brown, K., and Derse, C., 1989, An assessment of the effects of glucocorticoid on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotriene B4 by purified human neutrophils, J. Pharmacol. Exp. Ther., 250:598–602.
Schuller-Levis, G., Gordon, R.E., Park, E., Pendino, K., and Laskin, D., 1995, Taurine protects rat bronchioles from acute ozone-induced lung inflammation and hyperplasia, Exp. Lung Res., 21:877–888.
Weiss, S.J. 1989, Tissue destruction by neutrophils, New Engl. J. Med., 320:365–375.
Weiss, S.J., Kline, R., Slivka, A., and Wei, M., 1982, Chlorination of taurine by human neutrophils, evidence for hypochlorous acid generation, J. Clin. Invest., 70:598–607.
Witko, V., Nguyen, A.T., and Descamps-Latscha, B., 1992, Microtiter plate assay for phagocyte-derived taurine chloramine, J. Clin. Lab. Anal., 6:47–53.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Park, E., Alberti, J., Quinn, M.R., Schuller-Levis, G. (1998). Taurine Chloramine Inhibits the Production of Superoxide Anion, IL-6 and IL-8 in Activated Human Polymorphonuclear Leukocytes. In: Schaffer, S., Lombardini, J.B., Huxtable, R.J. (eds) Taurine 3. Advances in Experimental Medicine and Biology, vol 442. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0117-0_23
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0117-0_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0119-4
Online ISBN: 978-1-4899-0117-0
eBook Packages: Springer Book Archive