Abstract
Recent experiments have implicated transmembrane voltage as the driving force of OHC motility (Santos-Sacchi and Dilger, 1988a,b; Iwasa and Kachar, 1989). A voltage dependence of OHC motility clearly implies that a charged voltage sensing particle must reside in the OHC membrane, and as was predicted for voltage dependent ionic channels (Hodgkin and Huxley, 1952), particle movement should occur under an applied transmembrane voltage. Gating currents associated with the movement of the presumed voltage sensor in OHCs have been described by Ashmore (1989).
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Santos-Sacchi, J. (1990). Fast Outer Hair Cell Motility: How Fast is Fast?. In: Dallos, P., Geisler, C.D., Matthews, J.W., Ruggero, M.A., Steele, C.R. (eds) The Mechanics and Biophysics of Hearing. Lecture Notes in Biomathematics, vol 87. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4341-8_9
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DOI: https://doi.org/10.1007/978-1-4757-4341-8_9
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