Abstract
The neutral amino acid, γ-aminobutyric acid (GABA), is an inhibitory transmitter in the central nervous system (CNS). Furthermore, GABA is involved as a neurotransmitter and/or a paracrine effector in the regulation of a variety of physiological mechanisms in the periphery. Some of these latter functions may be under central GABA control; others are managed by local GABA neurons. A large percentage, perhaps the majority, of central neurons are under GABA control. The complex mechanisms underlying the GABA-mediated neurotransmission have been extensively studied, using a broad spectrum of electrophysiological, neurochemical, pharmacological, and in recent years, molecular biological techniques (Krnjevic, 1974; Curtis and Johnston, 1974; Olsen and Venter, 1986; Redburn and Schousboe, 1987; Bowery and Nistico, 1989; Bowery et al., 1990; Biggio and Costa, 1990; Schousboe et al., 1992a).
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Krogsgaard-Larsen, P., Frølund, B., Ebert, B. (1997). GABAA Receptor Agonists, Partial Agonists, and Antagonists. In: Enna, S.J., Bowery, N.G. (eds) The GABA Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2597-1_3
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