Abstract
The etiology and cellular pathogenesis of human SLE and of the spontaneously arising SLE-like diseases of mice are still poorly understood. Especially, the possible participation of T helper (TH) cells and, if this exists, the mode of action by which it causes the formation of multiple IgG autoantibodies is unclear (1). There is general agreement, however, that in both SLE and SLE-like conditions there is a B-cell hyperactivity (1), which has sometimes been referred to as “polyclonal” B-cell stimulation (2). Since potentially autoreactive B cells exist in normal individuals (3), they might be switched on to antibody production in states of generalized B-cell hyperactivity. Indeed, it has been possible to induce the formation of various SLE-like autoantibodies in nonautoimmune strains of mice by the administration of the polyclonal B-cell activator lipopolysaccharide (LPS) (4,5). However, there are no reports which indicate that LPS can induce the severe clinical and pathological alterations characteristic of SLE. Moreover, there is no evidence suggesting that human SLE patients are exposed to an abnormal load of bacterial products capable of inducing polyclonal B-cell stimulation.
Supported by a grant from the Dutch Kidney Foundation, Amsterdam.
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References
A.D. Steinberg, D.P. Huston, J.D. Taurog, J.S. Cowdery, and E.S. Raveche. Immunol. Rev. 55:121 (1981).
S. Izui, P.J. McConahey, and F.J. Dixon, J. Immunol. 121:2213 (1978).
A.C. Allison, in: “Autoimmunity”, N. Talal, ed. Academic Press, Inc., New York (1977).
D. Primi, L. Hammarstrom, C.I.E. Smith, and G. Moller. J. Exp. Med. 145:21 (1977).
S. Izui, P.H. Lambert, G.J. Fournie, H. Turler, and P.A. Miescher. J. Exp. Med. 145:1115 (1977).
P.J. Fialkow, C. Gilchrist, and A.C. Allison. Clin. Exp. Immunol. 12:479 (1973).
E. Gleichmann, and H. Gleichmann. Eur. J. Immunol. 6:899 (1976).
J.P.W. van der Veen, A.G. Rolink, and E. Gleichmann. J. Immunol. 127 (1981) in press.
E.H. van Elven, A.G. Rolink, F.M. van der Veen, Ph. Issa, Th. M. Duin, and E. Gleichmann. Submitted.
E. Gleichmann, H. Gleichmann, and W. Wilke. Transplant. Rev. 31:156 (1976).
E.H. van Elven, J. Agterberg, S. Sadal, and E. Gleichmann. J. Immunol. 126:1684 (1981).
E.H. van Elven, A.G. Rolink, F. van der Veen, and E. Gleichmann. J. Exp. Med. 153:1474 (1981).
S.T. Pals, T. Radaszkiewicz, and E. Gleichmann. This volume.
D.H. Katz, in : “Lymphocyte Differentiation, Recognition and Regulation”, p. 482, Academic Press, Inc., New York (1977).
G.J. Elfenbein, I. Green, and W.E. Paul. Eur. J. Immunol. 3:640 (1973).
E. Gleichmann, and H. Gleichmann, in: “Immunoregulation and Autoimmunity”, R.S. Krakauer and M.K. Cathcart, eds. p. 73, Elsevier North Holland, Inc., New York (1980).
H. Gleichmann, S.T. Pals, T. Radaszkiewicz, and M. Wasser. This volume.
L.A. Aarden, and R. Smeenk, in: “Immunological Methods”, Vol. II, I. Lefkovits, ed. , p. 75, Academic Press, New York (1981).
P.S. Esquivel, Y.M. Kong, and N.R. Rose. Cell. Immunol. 37:14 (1978).
M.B. Rittenberg, and K.L. Pratt. Proc. Soc. Exp. Biol. Med. 132:575 (1969).
P. Bretscher. Cell. Immunol. 6:1 (1973).
H. Cantor, and E. Boyse. Contemp. Top. Immunobiol. 7:47 (1977).
G.G.B. Klaus, in: “B and T Cells in Immune Recognition”, F. Loor and G.E. Roelants, eds., p. 235, John Wiley and Sons, Chicester (1977).
G.W. Hoffmann. Contemp. Top. Immunobiol. 11:185 (1980).
E.P. Ornellas, and D.W. Scott. Cell. Immunol. 11:108 (1974).
J. Andersson, and F. Melchers, in: “B Lymphocytes in the Immune Response”, N. Klinman, D.E. Mosier, I. Scher, and S. Vitetta, eds., Elsevier North Holland, New York, in press.
W. Hijmans, D. Doniach, I.M. Roitt, and E.J. Holborow. Brit. Med. J. 5257:909 (1961).
L.M. Mulhern, A.T. Masi, and L.E. Shulman. Lancet 2:508 (1966).
P.J. Maddison, and M. Reichlin. Arthr. Rheum. 20:819 (1977).
A.N. Theofilopoulos, D.L. Shawler, R.A. Eisenberg, and F.J. Dixon. J. Exp. Med. 151:446 (1980).
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van der Veen, F.M., Rolink, A.G., Gleichmann, E. (1982). Autoimmune Disease Strongly Resembling Systemic Lupus Erythematosus (SLE) in F1 Mice Undergoing Graft-Versus-Host Reaction (GVHR). In: Nieuwenhuis, P., van den Broek, A.A., Hanna, M.G. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 149. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9066-4_92
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