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The Structure and Expression of the Human Insulin-Like Growth Factor Genes

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Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

Abstract

The insulin-like growth factors (IGF) are a group of peptides involved in mammalian growth and development (37). The complete structures of two major species were first elucidated by Rinderknecht and Humbel (27,28). IGF-I is a basic peptide of 70 amino acids which mediates the growth promoting action of growth hormone and plays an important role in postnatal growth. The biological action of IGF-II, a 67 amino acids long peptide, is less obvious. It is thought to stimulate a variety of growth promoting processes in the fetus but several studies also indicate a function for IGF-II in the postnatal stage (4).

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Author information

Authors and Affiliations

  1. Laboratory for Physiological Chemistry, State University of Utrecht, Vondellaan 24a, 3521 GG, Utrecht, The Netherlands

    Pieternella Holthuizen

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  1. Pieternella Holthuizen
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek LeRoith

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada

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© 1989 Plenum Press, New York

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Holthuizen, P. (1989). The Structure and Expression of the Human Insulin-Like Growth Factor Genes. In: LeRoith, D., Raizada, M.K. (eds) Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5685-1_8

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  • DOI: https://doi.org/10.1007/978-1-4684-5685-1_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5687-5

  • Online ISBN: 978-1-4684-5685-1

  • eBook Packages: Springer Book Archive

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