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Current Views of the Biology of Cancer

  • Chapter
Carcinogen Risk Assessment

Part of the book series: Contemporary Issues in Risk Analysis ((CIRA,volume 3))

Abstract

In order to place the different methods used to estimate carcinogenic risk from chemical exposure into context, and to help decide on the best approach to improve this process, it is useful to discuss carcinogenesis with an emphasis on mechanism. Although the mecha nism of action of no carcinogen is completely characterized, the efforts over the last ten years have been very fruitful, and mechanistic explanations of a number of components in the grand design that is carcinogenesis have been described in detail.

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References

  • Ahmed, F. E. and Setlow, R. B., 1978, Excision repair in mammalian cells, in: DNA Repair Mechanisms (P. C. Hanawalt, E. C. Friedberg and C. F. Fox, eds.), pp. 333–336, Academic Press, New York.

    Google Scholar 

  • Ames, B. N., 1983, Dietary carcinogens and anticarcinogens, Science 221:1256–1263.

    PubMed  CAS  Google Scholar 

  • Argyris, T. S., 1982, Epidermal tumor promotion by regeneration, in: Carcinogenesis: A Comprehensive Survey ,Vol. 7 (E. Hecker, N. E. Fusenig, W. Kunz, F. Marks, and H. W. Thielmann, eds.), pp. 43–48, Raven Press, New York.

    Google Scholar 

  • Baldwin, R. W., and Price, M. R., 1982, Neoantigen expression in chemical carcinogenesis, in: Cancer: A Comprehensive Treatise Etiology, Chemical and Physical Carcinogenesis ,Vol. 1, 2nd Ed. (F. F. Becker, ed.), pp. 507–548, Plenum Press, New York.

    Google Scholar 

  • Barker, W. C, and Dayhoff, M. O., 1982, Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase, Proc. Natl. Acad. Sci. USA 79:2836–2839.

    PubMed  CAS  Google Scholar 

  • Becker, F. F. (ed.), 1982, Cancer: A Comprehensive Treatise Etiology, Vol. 1–5 ,2nd Ed., Plenum Press, New York.

    Google Scholar 

  • Berenblum, I., 1982, Sequential aspects of chemical carcinogenesis: Skin, in: Cancer: A Comprehensive Treatise Etiology, Chemical and Physical Carcinogenesis, Vol. 1: 2nd Ed. (F. F. Becker, ed.), pp. 451 – 484, Plenum Press, New York.

    Google Scholar 

  • Bishop, J. M., 1987, Molecular biology of cancer, Science 235:305–311.

    PubMed  CAS  Google Scholar 

  • Bister, K., and Jansen, H., 1986, Oncogenes in retroviruses and cell: Biochemical and molecular genetics, Adv. Cancer Res. 47:99–188.

    PubMed  CAS  Google Scholar 

  • Bos, R. P., Koopman, J., Theuws, J., Kennis, H., and Henderson, P. Th., 1986, Appearance and reappearance of mutagens in urine from rats after oral administration of direct brown 95, due to coprophagy, Toxicology 39:85–89.

    CAS  Google Scholar 

  • Bowden, G. T., Giesselbach, B., and Fusenig, N. E., 1978, Post-replication repair of DNA in ultraviolet light-irradiated normal and malignantly transformed mouse epidermal cell cultures. Cancer Res. 38:2709–2718.

    PubMed  CAS  Google Scholar 

  • Bridges, B. A., 1981, Some DNA-repair-deficient human syndromes and their implications for human health, Proc. R. Soc. London B 212:263–278.

    CAS  Google Scholar 

  • Brooks, A. L., Benjamin, S. A., James, R. K., and McClellan, R. O., 1982, Interaction of 144Ce and partial hepatectomy in the production of liver neoplasms in the Chinese hamster, Radiat. Res. 91:573–588.

    PubMed  CAS  Google Scholar 

  • Caldwell, J., 1982, Conjugation reactions in foreign-compound metabolism: Definition, consequences, and species variations, Drug Metab. Rev. 13:745–777. Carroll, K. K., 1980, Lipids and carcinogenesis, J. Environ. Pathol. Toxicol. 3:253–271. Cerniglia, C. E., Freeman, J. P., Franklin, W., and Pack, L. D., 1982, Metabolism of benzidine and benzidine-congener based dyes by human, monkey and rat intestinal bacteria, Biochem. Biophys. Res. Comm. 107:1224–1229.

    Google Scholar 

  • Coffin, J. M., Varmus, H. E., Bishop, J. M., Essex, M., Hardy, W. D., Jr., Martin, G. S., Rosenberg, N. E., Scolnick, E. M., Weinberg, R. A., and Vogt, P. K., 1981, Proposal for naming host-cell derived inserts in retrovirus genomes, J. Virol. 40:953–957.

    PubMed  CAS  Google Scholar 

  • Conney, A. H., Miller, E. C., and Miller, J. A., 1956, The metabolism of methylated aminoazo dyes: V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene, Cancer Res. 16:450–460.

    PubMed  CAS  Google Scholar 

  • Cory, S., 1986, Activation of cellular oncogenes in hematopoietic cells by chromosome translocation, Adv. Cancer Res. 47:189–234.

    PubMed  CAS  Google Scholar 

  • DeBethizy, J. D., Sherrill, J. M., Kickent, D. E., and Hamm, T. E., Jr., 1983, Effects of pectin-containing diets on the hepatic macromolecular covalent binding of 2,6-dinitro-[3H]toluene in Fischer 344 rats, Toxicol. Appl. Pharm. 69:369–376.

    CAS  Google Scholar 

  • Deutsch, W. A., and Linn, S., 1979, DNA binding activity from cultured human fibroblasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites, Proc. Natl. Acad. Sci. USA 76:141– 144.

    PubMed  CAS  Google Scholar 

  • Diamond, L., O’Brien, T. G., and Baird, W. M., 1980, Tumor promoters and the mechanism of tumor promotion, Adv. Cancer Res. 32:1–74.

    PubMed  CAS  Google Scholar 

  • Doll, R., and Peto, R., 1981, The cause of cancer: Quantitative estimates of avoidable risks of cancer in the United States today, J. Natl. Cancer Inst. 66:1193–1308.

    Google Scholar 

  • Doolittle, R. F., Hunkapiller, M. W., Hood, L. E., Devare, S. G., Robbins, K. C., Aaronson, S. A., and Antoniades, H. N., 1983, Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor, Science 221:275–277.

    PubMed  CAS  Google Scholar 

  • Dunphy, W. G., Delclos, K. B., and Blumberg, P. M., 1980, Characterization of specific binding of [3H]phorbol 12,13-dibutyrateand [3H]phorbol 12-myristate-13-acetate to mouse brain, Cancer Res. 40:3635–3641.

    CAS  Google Scholar 

  • Eisenstadt, E., Warren, A. J., Porter, J., Atkins, D., and Miller, J. H., 1982, Carcinogenic epoxides of benzo(a)pyrene and cyclopenta(cd)pyrene induce base substitutions via specific transversions, Proc. Natl. Acad. Sci. USA 79:1945–1949.

    PubMed  CAS  Google Scholar 

  • Embleton, M. J., and Middle, J. G., 1981, Immune responses to naturally occurring rat sarcomas, Br. J. Cancer 43:44–52.

    PubMed  CAS  Google Scholar 

  • Emerit, I., and Cerutti, P., 1982, The tumor promoter phorbol-12-myristate-13-acetate induces chromosome aberrations in human lymphocytes via indirect action, in: Mechanism of Chemical Carcinogenesis (C. C. Harris and P. A. Cerutti, eds.), pp. 495–498, Arthur R. Liss, New York.

    Google Scholar 

  • Farber, E., 1984, Chemical carcinogenesis: A current biological perspective, Carcinogenesis 5:1–5.

    PubMed  CAS  Google Scholar 

  • Farber, E., and Cameron, R., 1980, The sequential analysis of cancer development, Adv. Cancer Res. 31:125– 226.

    PubMed  CAS  Google Scholar 

  • Fidler, I. J., Gersten, D. M., and Hart, I. R., 1978, The biology of cancer invasion and metastasis, Adv. Cancer Res. 28:149–250.

    PubMed  CAS  Google Scholar 

  • Folkman, J., and Klagsburn, M., 1987, Angiogenic factors, Science 235:442–446.

    PubMed  CAS  Google Scholar 

  • Fujiwara, Y., and Tatsumi, M., 1976, Replicative bypass repair of ultraviolet damage to DNA of mammalian cells: Caffeine sensitive and caffeine resistant mechanisms, Mutat. Res. 37:91–110.

    PubMed  CAS  Google Scholar 

  • Gerchman, L. L., and Ludlum, D. B., 1973, The properties of 06-methylguanine in templates for RNA polymerase, Biochim. Biophys. Acta 308:310–316.

    PubMed  CAS  Google Scholar 

  • Goldman, P., 1978, Biochemical pharmacology of the intestinal flora, Ann. Rev. Pharmacol. Toxicol. 18:523– 539.

    CAS  Google Scholar 

  • Goldstein, B. D., Witz, G., Amoruso, M., Stone, D. S., and Troll, W., 1981, Stimulation of human poly morphonuclear leukocyte superoxide anion radical production by tumor promoters, Cancer Lett. 11:257– 262.

    PubMed  CAS  Google Scholar 

  • Greenberger, J. S., Newberger, P. E., Karpas, A., and Moloney, W. C, 1978, Constitutive and inducible granulocyte-macrophage functions in mouse, rat and human myeloid leukemia-derived continuous tissue culture lines, Cancer Res. 38:3340–3348.

    PubMed  CAS  Google Scholar 

  • Grunberger, D., and Weinstein, I. B., 1979, Conformational changes in nucleic acids modified by chemical carcinogens, in: Chemical Carcinogens and DNA (P. L. Grover ed.), pp. 59–93, CRC Press, Boca Raton, Florida. Guernsey, D. L., Ong, A., and Borek, C., Thyroid hormone modulation of X-ray-induced in vitro neoplastic transformation, Nature 288:591–592.

    Google Scholar 

  • Hart, I. R., and Fidler, I. J., 1980, Cancer invasion and metastasis, Q. Rev. Biol. 55:121–142.

    CAS  Google Scholar 

  • Hart, R. W., and Turturro, A., 1981, Evolution and longevity-assurance processes, Naturwissenschaften 68:552–557.

    PubMed  CAS  Google Scholar 

  • Hart, R. W., Setlow, R. B., and Woodhead, A. D., 1977, Evidence that pyrimidine dimers in DNA can give rise to tumors, Proc. Natl. Acad. Sci. USA 74:5574–5578.

    PubMed  CAS  Google Scholar 

  • Hart, R. W., Fu, P. P., and Chang, M. J. W., 1982, Comparative removal of polycyclic aromatic hydrocarbon-DNA adducts in vivo, in: Sixth International Symposium on Polynuclear Aromatic Hydrocarbons: Physical and Biological Chemistry (W. M. Cooke, A. J. Dennis, and G. L. Fisher, eds.), pp. 39–72, Battelle Press, Columbus, Ohio.

    Google Scholar 

  • Heppner, G. H., 1984, Tumor heterogenity, Cancer Res. 44:2259–2265.

    PubMed  CAS  Google Scholar 

  • Herlyn, M., Steplewski, Z., Herlyn, D., and Koprowski, H., 1979, Colo-rectal carcinoma-specific antigen: detection by means of monoclonal antibodies, Proc. Natl. Acad. Sci. USA 76:1438.

    PubMed  CAS  Google Scholar 

  • Hewitt, H. B., 1978, The choice of animal tumors for experimental studies of cancer therapy, Adv. Cancer Res. 27:149–200.

    PubMed  CAS  Google Scholar 

  • Hurley, J. B., Simon, M. I., Teplow, D. B., Robishaw, J. D., and Gilman, A. G., 1984, Homologies between signal transducing G proteins and ras gene products, Science 226:860–862.

    PubMed  CAS  Google Scholar 

  • Ingbar, S. H., Bauman, A., and Braverman, L. E., 1984, Studies of the effects of Chronic Erthyrosine Feeding on Various Aspects of Thyroid Hormone Economy in Rats. Submitted to the Food and Drug Administration as part of “Further studies on the thyroid effects of FD&C Red No. 3,” Dec. 4, 1984. FDA Color Additive Petition 96, Docket No. 76N-0366, Administrative Record Index # 299. Food and Drug Administration, Rockville, Maryland.

    Google Scholar 

  • Interagency Staff Group, 1986, Chemical carcinogens: A review of the science and its associated principles, Environ. Health Perspect. 67:201–282.

    Google Scholar 

  • Karin, M., Haslinge, A., Holtgreve, H., Richards, R. I., Krauter, P., Westphal, H. W., and Beato, M., 1984, Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene, Nature 308:513–519.

    PubMed  CAS  Google Scholar 

  • Kelner, A., 1949, Effect of visible light on the recovery of Streptomyces griseus conida from ultraviolet irradiation injury, Proc. Natl. Acad. Sci. USA 35:73–79.

    PubMed  CAS  Google Scholar 

  • Ketterer, B., 1980, Interactions between carcinogens and proteins, Br. Med. Bull. 36:71–78.

    PubMed  CAS  Google Scholar 

  • Kitagawa, T., Hino, O., Nomura, K., and Sugano, H., 1984, Dose-response studies of the promoting and anticarcinogenic effects of phenobarbital and DDT in the rat hepatocarcinogenesis, Carcinogenesis 5:1643–1656.

    Google Scholar 

  • Klein, G., 1981, The role of gene dosage and genetic transpositions in carcinogenesis, Nature 294:313–318.

    PubMed  CAS  Google Scholar 

  • Kraemer, K. H., Lee, M. M., and Scotto, J., 1982, Diseases of environmental-genetic interaction: Preliminary report on a retrospective study of neoplasia in 268 xeroderma pigmentosum patients, in: Environmental Mutagens and Carcinogens (T. Sugimura, S. Kondo, and H. Takebe, eds.), pp. 605–612, Arthur R. Liss, New York.

    Google Scholar 

  • Kriek, E., 1972, Persistent binding of a new reaction product of the carcinogen N-hydroxy-N-2-acety-laminofluorene with guanine in rat liver DNA in vivo, Cancer Res. 32:2042–2048.

    PubMed  CAS  Google Scholar 

  • Kripke, M. L., 1974, Antigenicity of murine mouse skin tumors induced by ultraviolet light, J. Natl. Cancer Inst. 53:1333–1336.

    PubMed  CAS  Google Scholar 

  • Kripke, M. L., 1979, Speculations on the role of ultraviolet radiation in the development of malignant melanoma, J. Natl. Cancer Inst. 63:541–548.

    PubMed  CAS  Google Scholar 

  • Lam, L. K. T., Sparnins, V. L., Hochalter, J. B., and Wattenberg, L. W., 1981, Effects of 2- and 3-tert-butyl-4-hydroxyanisole on glutathione S-transferase and epoxide hydrolase activities and sulfhydryl levels in liver and forestomach of mice, Cancer Res. 41:3940–3943.

    PubMed  CAS  Google Scholar 

  • Lee, W., Bookstein, R., Hong, F., Young, L., Shew, J., and Lee, E. Y., 1987, Human Retinoblastoma susceptibility gene: Cloning, identification and sequence, Science 235: 1394–1399.

    CAS  Google Scholar 

  • Lin, J.-K., Miller, J. A., and Miller, E. C, 1977, 2,3-Dihydro-2-(guan-7-yl)-3-hydroxy-aflatoxin B1, a major acid hydrolysis product of aflatoxin B1 -DNA or B1 -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo, Cancer Res. 37:4430–4438.

    Google Scholar 

  • Lindahl, T., and Nyberg, B., 1972, Rate of depurination of native deoxyribonucleic acid, Biochemistry 11:3610–3618.

    PubMed  CAS  Google Scholar 

  • Lindahl, T., and Nyberg, B., 1972, Rate of depurination of native deoxyribonucleic acid, Biochemistry 11:3610–3618. Lindahl, T., Rydberg, B., Hjebnigren, T., Olsson, M., and Jacobson, A., 1982, Cellular defense mechanisms against alkylation of DNA, in: Molecular and Cellular Mechanisms of Mutagenesis ,(J. Lemontt and W. M. Generoso, eds.), pp. 89–102, Plenum Press, New York.

    Google Scholar 

  • Linn, S., Kuhnlein, U., and Deutsch, A., 1978, Enzymes from human fibroblasts for the repair of AP DNA, in: DNA Repair Mechanisms (P. C. Hanawalt, E. C. Friedberg, and C. F. Fox, eds.), pp. 199–203, Academic Press, New York.

    Google Scholar 

  • Liotta, L. A., Tryggvason, K., Garbisa, S., Hart, I., Foltz, C. M., and Shafie, S., 1980, Metastatic potential correlates with enzymatic degradation of basement membrane collagen, Nature 284:67–68.

    PubMed  CAS  Google Scholar 

  • Lipetz, P. D., Galsky, A. G., and Stephens, R. E., 1982, Relationship of DNA tertiary and quaternary structure to carcinogenic processes, Adv. Cancer Res. 36:165–210.

    PubMed  CAS  Google Scholar 

  • Littlefield, N. A., Farmer, J. H., Gaylor, D. W.,and Sheldon, W. G., 1979a, Effects of dose and time in a long-term, low-dose carcinogenic study, J. Environ. Pathol. Toxicol. 3:17–34.

    Google Scholar 

  • Littlefield, N. A., Greenman, D. L., Farmer, J. H., and Sheldon, W. G., 1979b, Effects of continuous and discontinued exposure to 2-AAF on urinary bladder hyperplasia and neoplasia, J. Environ. Pathol. Toxicol. 3:35–54.

    Google Scholar 

  • Lu, A. Y. H., 1979, Multiplicity of liver drug metabolizing enzymes, Drug Metab. Rev. 10:187–208.

    PubMed  CAS  Google Scholar 

  • Magee, P. N., 1977, The relationship between mutagenesis, carcinogenesis and teratogenesis, in: Progress in Genetic Toxicology (D. Scott, B. A. Bridges, and F. H. Sorbels, eds.), pp. 15–27, Elsevier/North Holland Biomedical Press, Amsterdam.

    Google Scholar 

  • Maher, V. M., Rowan, L. A., Silinskas, K. C., Kateley, S. A., and McCormick, J. J., 1982, Frequency of UV-induced neoplastic transformation of diploid human fibroblasts is higher in xeroderma pigmentosum cells than in normal cells, Proc. Natl. Acad. Sci. USA 79:2613–2617.

    PubMed  CAS  Google Scholar 

  • Marks, F., and Furstenberger, G., 1984, Stages of tumor promotion in skin, IARC Sci. Pub. 56:13–22.

    CAS  Google Scholar 

  • Mc-Grath, J. P., Capon, D. J., Goeddewl, D. V., and Levinson, A. D., 1984, Comparative biochemical properties of normal and activated human ras p21 protein, Nature 310:644–649.

    CAS  Google Scholar 

  • McKhann, C. F., 1982, Tumor immunology: Past, present and future, in: Accomplishments in Cancer Research 1981 (J. G. Former and J. E. Rhoads, eds.) pp. 125–137, Lippincott, Philadelphia.

    Google Scholar 

  • Miao, R. M., Fieldsteel, A. H., and Fodge, D. W., 1978, Opposing effects of tumour promoters on erythroid differentiation, Nature 274:271–272.

    PubMed  CAS  Google Scholar 

  • Miller, E. C, and Miller, J. A., 1976, The metabolism of chemical carcinogens to reactive electrophiles and their possible mechanism of action in carcinogenesis, in: Chemical Carcinogens (American Chemical Society Monograph, No. 173) (C. Searle, ed.), pp. 737–762, American Chemical Society, Washington, D.C.

    Google Scholar 

  • Mintz, B., and Fleischman, R., 1981, Teratocarcinoma and other neoplasmas as developmental defects in gene expression, Adv. Cancer Res. 34:214–278.

    Google Scholar 

  • Morgan, R. W., and Hoffmann, G. R., 1983, Cycasin and its mutagenic metabolites, Mutat. Res. 114:19–58.

    PubMed  CAS  Google Scholar 

  • Murasaki, G., Zenser, T. Z., Davis, B. B., and Cohen, S. M., 1984, Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced bladder carcinogenesis and enhancement of forestomach car cinogenesis, Carcinogenesis 5:53–55.

    PubMed  CAS  Google Scholar 

  • Nagasawa, H., and Little, J. B., 1979, Effect of tumor promoters, protease inhibitors, and repair processes on X-ray-induced sister chromatid exchanges in mouse cells, Proc. Natl. Acad. Sci. USA 76:1943–1947.

    PubMed  CAS  Google Scholar 

  • Nishizuka, Y., 1986, Studies and perspectives of protein kinase C, Science 233:305–312.

    PubMed  CAS  Google Scholar 

  • Peterson, A. R., Landolph, J. R., Peterson, H., and Heidelberger, C., 1978, Mutagenesis of Chinese hamster cells is facilitated by thymidine and deoxycytidine, Nature 276:508–510.

    PubMed  CAS  Google Scholar 

  • Poste, G., and Nicolson, G. L., 1980, Arrest and metastasis of blood-borne tumor cells are modified by fusion of plasma membrane vesicles from highly metastatic cells, Proc. Natl. Acad. Sci. USA 77:399–403.

    PubMed  CAS  Google Scholar 

  • Radman, M., Villani, G., Boiteux, S., Defais, M., Caillet-Fauquet, P., and Spadari, S., 1977, On the mechanism and genetic control of mutagenesis induced by carcinogenic mutagens, in: Origins of Human Cancer: Mechanisms of Carcinogenesis, Vol. 4 (J. D. Watson, H. Hiatt, eds.), pp. 903–922, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.

    Google Scholar 

  • Rovera, G., O’Brien, T. G., and Diamond, L., 1977, Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture, Proc. Natl. Acad. Sci. USA 74:2894–2898.

    PubMed  CAS  Google Scholar 

  • Sandberg, A. A., 1980, The Chromosomes in Human Cancer and Leukemia ,Elsevier/North-Holland, Amsterdam. Sap ,J., Munoz, A., Damm, K., Goldberg, Y., Ghysdael, J., Leutz, A., Beug, H., and Vennstrom, B., 1986, The c-erb-A protein is a high-affinity receptor for thyroid hormone, Nature 324:635–640.

    Google Scholar 

  • Schirrmacher, V., 1985, Cancer metastasis: Experimental approaches, theoretical concepts, and impacts for treatment strategies, Adv. Cancer Res. 43:1–74.

    PubMed  CAS  Google Scholar 

  • Setlow, R. B., 1980, DNA repair pathways, in: DNA Repair and Mutagenesis in Eukaryotes (W. M. Generoso, M. D. Shelby, and F. J. de Serres, eds.), pp. 45–54, Plenum Press, New York.

    Google Scholar 

  • Sims, P., and Grover, P. L., 1974, Epoxides in polycyclic aromatic hydrocarbon metabolism and car cinogenesis, Adv. Cancer Res. 20165–274.

    PubMed  CAS  Google Scholar 

  • Slaga, T. J., 1983, Overview of tumor promotion in animals, Environ. Health Perspect. 50:3–14.

    PubMed  CAS  Google Scholar 

  • Stott, W. T., Reitz, R. H., Schumann, A. M., and Watanabe, P. G., 1981, Genetic and nongenetic events in neoplasia, Food Cosmet. Toxicol. 19:567–576.

    PubMed  CAS  Google Scholar 

  • Strauss, B., 1985, Cellular aspects of DNA repair, Adv. Cancer Res. 45:45–106.

    PubMed  CAS  Google Scholar 

  • Swenson, D. H., and Kadlubar, F. F., 1981, Properties of chemical mutagens and chemical carcinogens in relation to their mechanisms of action, in: Microbial Testers: Probing Carcinogenesis (I. C. Felkner, ed.), pp. 3–33, Dekker, New York.

    Google Scholar 

  • Tateishi, N., Higashi, T., Shinya, S., Naruse, A., and Sakamoto, Y., 1974, Studies on the regulation of glutathione level in rat liver, J. Biochem. (Tokyo) 75:93–103.

    PubMed  CAS  Google Scholar 

  • Taub, R., Kirsch, I., Morton, C., Lenoir, G., Swan, D., Tronick, S., Aaronson, S., and Leder, P., 1982, Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt’s lymphoma and murine plasmacytoma cells, Proc. Natl. Acad. Sci. USA 79: 7837–7841.

    PubMed  CAS  Google Scholar 

  • Terzaghi, M., and Little, J. B., 1976, X-radiation-induced transformation in a C3H mouse embryo-derived cell line, Cancer Res. 36:1367–1374.

    PubMed  CAS  Google Scholar 

  • Thakker, D. R., Levin, W., Buening, M., Yagi, H., Lehr, R. E., Wood, A. W., Conney, A. H., and Jerina, D. M., 1981, Species-specific enhancement by 7,8-benzoflavone of hepatic microsomal metabolism of benzo(e)pyrene 9,10-dihydrodiol to bay-region diol-epoxide, Cancer Res. 41:1389–1396.

    PubMed  CAS  Google Scholar 

  • Theofilopoulos, A. N., and Dixon, F. J., 1980, Immune complexes in human diseases: A review, Amer. J. Pathol. 100:531–594.

    Google Scholar 

  • Topal, M. D., and Baker, M.S., 1982, DNA precursor pool: A significant target for N-methyl-N-uitrosourea in C3H/10T1/2 clone 8 cells, Proc. Natl. Acad. Sci. USA 79:2211–2215.

    PubMed  CAS  Google Scholar 

  • Trus, M. D., Sodoroski, J. G., and Haseltine, W. A., 1982, Isolation and purification of a human locus homologous to the transforming gene (v-fes) of feline sarcoma virus, J. Biol. Chem. 257:2730–2733.

    PubMed  CAS  Google Scholar 

  • Turturro, A., and Hart, R. W., 1984, DNA repair mechanisms in aging, in: Comparative Biology of Major Age-Related Diseases: Current Status and Research Frontiers (D. G. Sciapelli and G. Migaki, eds.), pp. 19–45, Arthur R. Liss, New York.

    Google Scholar 

  • Van de Velde, C. J. H., Van Putten, L. M., and Zwaveling, A., 1977, A new metastasizing mammary carcinoma model in mice: Model characteristics and applications, Eur. J. Cancer 13:555–565.

    Google Scholar 

  • Verma, A. K., Conrad, E. A., and Boutwell, R. K., 1982, Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen, Cancer Res. 42:3519–3525.

    PubMed  CAS  Google Scholar 

  • Waring, M. J., 1981, DNA modification and cancer, Ann. Rev. Biochem. 50:159–192.

    PubMed  CAS  Google Scholar 

  • Warren, B. A., 1978, Platelet-tumor cell interactions: Morphological studies, in: Platelets: A Multidisciplinary Approach (G. D. Gaetano and S. Garattini, eds.), pp. 427–445, Raven Press, New York.

    Google Scholar 

  • Wattenberg, L. W., 1980, Inhibitors of chemical carcinogens, J. Environ. Pathol. Toxicol. 3:35–52.

    PubMed  CAS  Google Scholar 

  • Weinberg, R. A., 1982, Oncogenes of spontaneous and chemically induced tumors, Adv. Cancer Res. 36:149– 163.

    PubMed  CAS  Google Scholar 

  • Weinstein, I. B., 1981, Current concepts and controversies in chemical carcinogenesis, J. Supramol. Struct. Cell Biochem. 17:99–120.

    PubMed  CAS  Google Scholar 

  • Williams, R. T., 1959, Detoxification Mechanisms ,2nd Ed., Chapman and Hall, London.

    Google Scholar 

  • Young, J. F., and Kadlubar, F. F., 1982, A pharmacokinetic model to predict exposure of the bladder epithelium to urinary N-hydroxyarylamine carcinogens as a function of urine pH, voiding interval, and resorption, Drug. Metab. Dispos. 10:641–648.

    PubMed  CAS  Google Scholar 

  • Zur Hausen, H., O’Neill, F. J., Freese, U. K., and Hecker, E., 1978, Persisting oncogenic herpesvirus induced by the tumor promoter TPA, Nature 272:373–375.

    PubMed  Google Scholar 

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  1. National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, 72079, USA

    Ronald W. Hart & Angelo Turturro

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  2. Angelo Turturro
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  1. Office of Risk Analysis, Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, 37831-6109, USA

    Curtis C. Travis

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© 1988 Plenum Press, New York

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Hart, R.W., Turturro, A. (1988). Current Views of the Biology of Cancer. In: Travis, C.C. (eds) Carcinogen Risk Assessment. Contemporary Issues in Risk Analysis, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5484-0_2

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  • DOI: https://doi.org/10.1007/978-1-4684-5484-0_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5486-4

  • Online ISBN: 978-1-4684-5484-0

  • eBook Packages: Springer Book Archive

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