Skip to main content
SpringerLink
Log in

Anti-Adhesive Drugs and Tissue Oxygenation

  • Chapter
  • First Online:
Oxygen Transport to Tissue

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 37B))

Abstract

The intravascular agglutination of the formed elements of blood, which occurs under certain pathological conditions, results in peripheral circulation disturbances that may lead to blood flow stagnation and the plugging of small vessels with cell aggregates. [Bicher (1) and (2)] Of the blood cells involved, special attention has been given to the erythrocytes and platelets. These cells seem to possess the ability to start and accelerate the chain of events that leads to organic vessel occlusion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Bicher, H. I. Blood Cell Aggregation in Thrombotic Processes, Charles C. Thomas, Springfield, Ill., 1972.

    Google Scholar 

  2. Bicher, H. I. Anti-adhesive Drugs in Thrombosis, Throm. et Diath. Haem., Suppl. XXXXII:197–214, 1970.

    Google Scholar 

  3. Bicher, H. I. A Current Concept of Anti-thrombotic Therapy Based on the Pharmacological Effects of Drugs Preventing Platelet and Red Cell Aggregation, Proc. of the Second International Symposium on Atherosclerosis, Springer-Verlag, New York, pp. 536–541, 1970.

    Google Scholar 

  4. Bicher, H. I. and A. Beemer. Prevention, by an Anti-adhesive Drug, of Thrombosis Caused by Blood Cell Aggregation, Angiology, 21:413–441, 1970.

    Article  Google Scholar 

  5. Levi, J., H. I. Bicher and J. B. Rozenfeld. Platelet aggregation in Hypertensive Platelets Determined with a Modified SFP (Screen Filtration Pressure) Method, J. of Medicine, 1:132–141, 1970.

    CAS  Google Scholar 

  6. Bicher, H. I. 2-methyl-2-tert-butyl-ketolactone—an Anti-adhesive Drug Preventing Platelet and Red Cell Aggregation. Pharmacology, 4:152–162, 1970.

    Article  CAS  Google Scholar 

  7. Taub, W. and M. Cais. The Synthesis of Ketolactones with Potential Pharmacodynamic Properties, Bull. Res. Counc. Israel, 114:18, 1962.

    Google Scholar 

  8. Bicher, H. I. and M. H. Knisely. Brain Tissue Reoxygenation Time, Demonstrated with a New Ultramicro Oxygen Electrode, J. of Appl. Physiol., 28:387–390, 1970.

    Article  CAS  Google Scholar 

  9. Bicher, H. I. and J. W. Rubin. Clinical use of a new Intra-Arterial Catheter Electrode System, Oxygen Transport to Tissue, Plenum Press, New York, N. Y., in press.

    Google Scholar 

  10. O’Brien, J. R. Platelet Aggregation. Part. II. Some Results from a New Method of Study, J. Clin. Path., 15:452, 1962.

    Article  Google Scholar 

  11. Constantine, J. W. Inhibition of ADP Induced Platelet Aggregation by Histamine, Nature (Lond.) 207:91, 1965.

    Article  CAS  Google Scholar 

  12. Judah, J. D. Ciba Foundation Symposium on Enzymes and Drug Action, p. 339, Churchill, London, 1947.

    Google Scholar 

  13. Markwardt, F., W. Barthel and E. Glusa. Changes in the Histamine and Serotonin Content of Blood Platelets due to the Effect of Local Anesthetics, Naunyn Schmiedeberg’s Arch. Exp. Path. Pharm., 253:336, 1966.

    Article  CAS  Google Scholar 

  14. Knisely, M. H., D. D. Reneau and D. F. Bruley. The Development and use of Equations for Predicting the Limits on the Rates of Oxygen Supply to the Cells of Living Tissues and Organs, Angiology, 20:l-50, 1969.

    Article  Google Scholar 

  15. Opitz, E. and M. Schneider. Ueber Sauerstroffversorgung des Gehirns und den Mechanismus von Mangelwirkungen, Ergebn. Physiol., 46:126–260, 1950.

    Article  Google Scholar 

  16. Silver, I. The Measurement of Oxygen Tension in Tissue, Oxygen Measurements in Blood and Tissue and Their Significance, pp. 135–153, Boston: Little, Brown and Company, 1968.

    Google Scholar 

  17. Knisely, M. H. Intravascular Erythrocyte Aggregation (Blood Sludge), Handbook of Physiology, Circulation, Vol. III, Chap. 13, pp. 2249–2293, ed. Hamilton, W. F. & Dow, P. Baltimore: Williams and Wilkins, 1965.

    Google Scholar 

  18. DeBono, A. and N. Gozetopoulos. Experimental Pulmonary Embolism due to Red Cell Aggregation, Thorax 19:244–250, 1964.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anatomy, Medical University of South Carolina, Charleston, South Carolina, USA

    H. I. Bicher & M. H. Knisely

  2. Department of Chemical Engineering, Clemson University, Clemson, South Carolina, USA

    D. F. Bruley

Authors
  1. H. I. Bicher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. F. Bruley
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. H. Knisely
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Clemson University, Clemson, South Carolina, USA

    Duane F. Bruley (Professor of Chemical Engineering) (Professor of Chemical Engineering)

  2. University of Arkansas Medical Center, Little Rock, Arkansas, USA

    Haim I. Bicher (Associate Professor of Pharmacology) (Associate Professor of Pharmacology)

Rights and permissions

Reprints and permissions

Copyright information

© 1973 Plenum Press, New York

About this chapter

Cite this chapter

Bicher, H.I., Bruley, D.F., Knisely, M.H. (1973). Anti-Adhesive Drugs and Tissue Oxygenation. In: Bruley, D.F., Bicher, H.I. (eds) Oxygen Transport to Tissue. Advances in Experimental Medicine and Biology, vol 37B. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-5089-7_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5089-7_4

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-5091-0

  • Online ISBN: 978-1-4684-5089-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation