Abstract
An insufficient and heterogeneously distributed nutritive blood flow leads to an inadequate and nonuniform supply of O2 and substrates in many solid tumors (Vaupel, 1977, 1979, 1982). This deterioration of the supply conditions, which already occurs in very early growth stages and which is superimposed by a deterioration of diffusive transport during advanced growth stages, is paralleled by a decrease in the therapeutic efficacy of various cancer treatment modalities such as irradiation and chemotherapy with antiproliferative drugs. In the case of anticancer drugs, the efficiency may be reduced by affecting both pharmacokinetics and pharmacodynamics. In the latter case this is due to the development of a nutritional depletion, to the existence of tissue hypoxia or even anoxia and to the presence of severe tissue acidosis. One way to overcome this problem may be the use of a controlled hemo-dilution. Therefore, we investigated the effect of hemo-dilution on tumor blood flow (TBF).
Supported by the Deutsche Forschungsgemeinschaft (Va 57/2–3)
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References
Hint, H. , 1968, The pharmacology of dextran and the phys-siological background for the clinical use of Rheo-macrodex and Macrodex, Acta anaesth. belg., 19: 119.
Kitani, K., 1972, Solubility coefficients of 85-krypton and 133-xenon in water, saline, lipids, and blood, Scand. J. clin. Lab. Invest., 29: 167.
Messmer, K., Sunder- Plassmann, L., Klövekorn, W.P., and Holper, K., 1972, Circulatory significance of hemodilution: Rheological changes and limitations, Advan. Microcirculat., 4: 1.
Vaupel, P., 1974, Atemgaswechsel und Glucosestoffwechsel von Implantationstumoren (DS- Carcinosarkom) in vivo, Funktionsanalyse biolog. Systeme, 1: 1.
Vaupel, P., 1977, Hypoxia in neoplastic tissue, Microvasc. Res., 13: 399.
Vaupel, P., 1979, Oxygen supply to malignant tumors, in: Tumor Blood Flow, H.I. Peterson, ed., CRC Press, Boca Raton, Fla.
Vaupel, P., 1982, Pathophysiologie der Durchblutung maligner Tumoren, Funktionsanalyse biolog. Systeme, 8:1101 .
Vaupel, P., Ruppert, H., and Hutten, H., 1977, Splenic blood flow and intrasplenic flow distribution in rats, Pflügers Arch. 369: 193.
Vaupel, P., Ostheimer, K., and Müller- Klieser, W., 1980, Circulatory and metabolic responses of malignant tumors during localized hyperthermia, J. Cancer Res. Clin. Oncol., 98: 15.
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© 1984 Plenum Press, New York
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Jung, C., Müller-Klieser, W., Vaupel, P. (1984). Tumor Blood Flow and O2 Availability during Hemodilution. In: Bruley, D., Bicher, H.I., Reneau, D. (eds) Oxygen Transport to Tissue—VI. Advances in Experimental Medicine and Biology, vol 180. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4895-5_27
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DOI: https://doi.org/10.1007/978-1-4684-4895-5_27
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