Abstract
The elucidation of the biological basis of organ-specific tumor induction by chemicals is a major objective of cancer research. For many carcinogens, the principal site of tumor induction has been shown to vary with species, dose, route of administration, and age or developmental stage. Some species also exhibit marked differences in their overall susceptibility to certain classes of chemical carcinogens. Accordingly, to accurately predict the adverse effects of genotoxic agents in humans, the basic mechanisms underlying organ and species specificity must first be understood.
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© 1983 Plenum Press, New York
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Kleihues, P., Hodgson, R.M., Veit, C., Schweinsberg, F., Wiessler, M. (1983). DNA Modification and Repair in Vivo: Towards a Biochemical Basis of Organ-Specific Carcinogenesis by Methylating Agents. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_27
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DOI: https://doi.org/10.1007/978-1-4684-4400-1_27
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