Abstract
In 1967, the first author of this paper started intraperitoneal studies on the carcinogenicity of asbestos. Later Wagner and coworkers (1974) published their large inhalation experiment with five asbestos types and this provided the incentive to perform similar inhalation studies with man-made mineral fibres. This aim was achieved in 1983 after some years of planning and the construction of the facilities for inhalation toxicology at the Fraunhofer Institute in Hannover. It was a great disappointment that Muhle and coworkers (1987) at the new facilities could not even find a clear carcinogenic effect in the groups exposed to chrysotile or crocidolite. Even in a parallel injection study with about 109 chrysotile fibres there was no clear carcinogenic effect. In these experiments Californian chrysotile was used as a positive control following the recommendation of NIOSH. The crocidolite sample used gave an unequivocally positive result after intraperitoneal injection of a relatively low number of fibres but no significant carcinogenic effect could be detected in the inhalation study. This compares with the work of Wagner and others (1985, 1987) who also failed to reproduce the high tumour rates observed with crocidolite in their previous inhalation study.
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Bellmann, B., Muhle, H., Pott, F., König, H., Klöppel, H. and Spurny, K. (1987) Persistence of man-made mineral fibres (MMMF) and asbestos in rat lungs. Ann. Occup. Hyg. 31: 693–709.
Bellmann, B., Muhle, H. and Pott, F. (1990) Study on the durability of chemically different glass fibres in lungs on rats. Zb1.Hyg. 190:310–314. (German)
Coffin, D.L., Palekar, L.D., Cook, P.M. and Creason, J.P. (1989) Comparison of mesothelioma induction in rats by asbestos and nonasbestos mineral fibers: Possible correlation with human exposure data. In, “Biological interaction of Inhaled Mineral Fibers and Cigarette Smoke”, eds. Wehner,A.P., Felton,D.-L. Proceedings of an International Symposium/Workshop held at the Battelle Seattle Conference Center April 10–14, 1988, Seattle, Washington. Battelle Press, Columbus, Ohio. pp. 313–323.
Davis, J.M.G. and Jones, A.D. (1988) Comparisons of the pathogenicity of long and short fibres of chrysotile asbestos in rats. Br. J. Exp. Path. 69: 717–737.
Davis, J.M.G., Beckett, S.T., Bolton, R.E., Collings, P. and Middleton, A.P. (1978) Mass and number of fibres in the pathogenesis of asbestos-related lung disease in rats. Br. J. Cancer 37: 673–687.
Davis, J.M.G., Addison, J., Bolton, R.E., Donaldson, K., Jones, A.D. and Smith, T. (1986) The pathogenicity of long versus short fibre sample of amosite asbestos administered to rats by inhalation and intraperitoneal injection. Br. J. Exp. Path. 67: 415–430.
IARC (International Agency for Research on Cancer, ed.) (1987) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 42, “Silica and Some Silicates”. World Health Organization International Agency for Research on Cancer, Lyon.
IARC (International Agency for Research on Cancer, ed.) (1988) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Vol. 43, “Man-Made Mineral Fibres and Radon”. World Health Organization International Agency for Research on Cancer, Lyon.
Maltoni, C. and Minardi, F. (1989) Recent results of carcinogenicity bioassays of fibres and other particulate materials. In, “Non-Occupational Exposure to Mineral Fibres”, eds. Bignon,J., Peto,J. and Saracci,R. (IARC Scientific Publ. No. 90 ), International Agency for Research on Cancer, Lyon. pp. 46–53.
McClellan, R.O. (1990) Comments on proposal of Professor F. Pott for classifying the carcinogenicity of fibers. ( Manuscript).
Monchaux, G., Bignon, J., Jaurand, M.C., Lafuma, J., Sebastien, P., Masse, R., Hirsch, A. and Goni, J. (1981) Mesotheliomas in rats following inoculation with acid-leached chrysotile asbestos and other mineral fibres. Carcinogenesis 2: 229–236.
Muhle, H., Pott, F., Bellmann, B., Takenaka, S. and Ziem, U. (1987) Inhalation and injection ex-peri-ments in rats for testing MMMF on carcinogenicity. Ann. Occup. Hyg. 31 No.4B: 755–764.
Muhle, H., Bellmann, B. and Pott, F. (1990) Durability of various mineral fibers in rat lungs. (This volume).
Nikitina, O.V., Kogan, F.M., Vanchugova, N.N. and Frash, V.N. (1989) Comparative oncogenicity of basalt fibres and chrysotile asbestos. Gig. Tr. Prof Zabol. 4: 7–11. (Russian)
Pott, F. (1987a) The fibre as a carcinogenic agent. Zbl. Bakt. Hyg. B 184: 1–23. (German)
Pott, F. (1987b) Problems in defining carcinogenic fibres. Ann. Occup. Hyg. 31 No.4B: 799–802.
Pott, F. (1988) Umweltkanzerogene. In, “Ges.z.Förderung d. Lufthygiene u. Silikoseforschung e.V.”, ed. Düsseldorf, Umwelthygiene. Bd 20. Medizinisches Institut für Umwelthygiene. Jahresbericht 1987/88.–Stefan W. Albers, Düsseldorf. pp. 22–26.
Pott, F. (1989a) Carcinogenicity of fibers in experimental animals–Data and evaluation. In, “Assessment of Inhalation Hazards”, eds. Mohr,U. et al.. Integration and Extrapolation Using Diverse Data (ILSI Monographs), Springer, Berlin a.o. pp. 243–253.
Pott, F. (1989b) Questions to the cell biologists and proposals for a definition and classification of carcinogenic fibers derived from animal studies. In, “Effects of Mineral Dusts on Cells”, eds. Mossmann,B.T. and Begin,R.O. NATO ASI Series, Vol. H30, Springer, Berlin, Heidelberg. pp. 439–444.
Pott, F. (1990) Beurteilung der Kanzerogenität von Fasern aufgrund von Tierversuchen. Tagung “Faserförmige Stäube–Vorschriften, Wirkungen, Messung, Minderung” der Kommission Reinhaltung der Luft (KRdL) im VDI und DIN, Heidelberg, 11–13. Sept. 1990.
Pott, F. and Friedrichs, K.H. (1972) Tumoren der Ratte nach i.p.-Injektion faserförmiger Stäube. Naturwissenschaften 59: 318.
Pott, F., Friedrichs, K.H. and Huth, F. (1976) Ergebnisse aus Tierversuchen zur kanzerogenen Wirkung faserförmiger Stäube und ihre Deutung im Hinblick auf die Tumorentstehung beim Menschen. Zbl. Bakt. Hyg., I. Abt. Orig. B 162: 467–505.
Pott, F., Ziem, U., Reiffer, F.-J., Huth, F., Ernst, H. and Mohr, U. (1987) Carcinogenicity studies on fibres, metal compounds, and some other dusts in rats. Exp. Pathol. (Jena) 32: 129–152
Pott, F., Roller, M., Ziem, U., Reiffer, F.-J., Bellmann, B., Rosenbruch, M. and Huth, F. (1989) Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats. In, “Non- Occupational Exposure to Mineral Fibres”, eds. Bignon,J., Peto,J. and Saracci,R. IARC Sci. Publ. No. 90. Intern. Agency for Research on Cancer, Lyon. pp. 173–179.
Pott, F., Bellmann, B., Muhle, H., Rödelsperger, K., Rippe, R.M., Roller, M. and Rosenbruch, M. (1990a) Intraperitoneal injection studies for the evaluation of the carcinogenicity of fibrous phyllosilicates. In, “Health Related Effects of Phyllosilicates”, ed. Bignon,J. NATO ASI Series G: Ecological Sciences. Vol. 21, Springer, Berlin a.o. pp. 319–329.
Pott, F., Schlipköter, H.-W., Roller, M., Rippe, R.M., Germann, P.G., Mohr, U. and Bellmann, B. (1990b) Carcinogenicity of glass fibres with different durability. Zbl. Hyg. 189: 563–566. (German)
Pott,F., Rippe,R.M., Roller,M., Rosenbruch,M. and Huth,F. (1990e) Vergleichende Untersuchungen über die Kanzerogenität verschiedener Nickellegierungen (Schriftenreihe der Bundesanstalt für Arbeitsschutz. Forschung), Wirtschaftsverl. NW, Verl. f. neue Wissenschaft, Bremerhaven, Dortmund. (in press).
Rödelsperger, K., Brückel, B., Patrzich, R., Pott, F. and Woitowitz, H.-J. (1990) Concentrations of fibres in phyllosilicates. In, “Health Related Effects of Phyllosilicates”, ed. Bignon,J., NATO ASI Series G: Ecological Sciences Vol. 21, Springer, Berlin a.o. pp. 75–83.
Smith, D.M., Ortiz, L.W., Archuleta, R.F. and Johnson, N.F. (1987) Health effects in hamsters and rats exposed chronically to man-made vitreous fibres. Ann. Occup. Hyg. 31: 731–754.
Stanton, M.F. and Wrench, C. (1972) Mechanisms of mesothelioma induction with asbestos and fibrous glass. J. Natl. Cancer Inst. 48: 797–821.
Stanton, M.F., Layard, M., Tegeris, A., Miller, E., May, M. and Kent, E. (1977) Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J. Natl. Cancer Inst. 58: 587–603.
Stanton, M.F., Layard, M., Tegeris, A., Miller, E., May, M., Morgan, E. and Smith, A. (1981) Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J. Natl. Cancer Inst. 67: 965–975.
Wagner, J.C. (1988) Animal models of pneumoconiosis I. Biological effects of short fibres. VIIth International Conference on Pneumoconioses, Pittsburgh, U.S.A., August, 23–26, 1988.
Wagner, J.C., Berrry, G. and Timhrell, V. (1973) Mesotheliomata in rats after inoculation with asbestos and other materials. Br. J. Cancer 28: 173–185.
Wagner, J.C., Berry, G. and Skidmore, J.W. (1976) Studies of the carcinogenic effects of fiber glass of different diameters following intrapleural inoculation in experimental animals. In, “Occupational Exposure to Fibrous Glass”, ed. US Department of Health, Education and Welfare, National Institute for Occupational Safety and Health. Proceedings of a Symposium, College Park, Maryland, June 26–27, 1974 (HEW Publ. No. NIOSH 76–151 ), U.S. Government, Printing Office, Washington, D.C. pp. 193–204.
Wagner, J.C., Griffiths, D.M. and Munday, D.E. (1987) Experimental studies with palygorskite dusts. Br. J. Indust. Med. 44: 749–753.
Wagner, J.C., Berry, G., Skidmore, J.W. and Timbrell, V. (1974) The effects of the inhalation of asbestos in rats. Br. J. Cancer 29: 252–269.
Wagner, J.C., Skidmore, J.W., Hill, R.J. and Griffiths, D.M. (1985) Erionite exposure and mesotheliomas in rats. Br. J. Cancer 51: 727–730.
WHO (World Health Organization, ed.) (1988) Man-Made Mineral Fibres (Environmental Health Criteria 77 ), World Health Organization, Geneva.
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Pott, F., Roller, M., Rippe, R.M., Germann, PG., Bellmann, B. (1991). Tumours by the Intraperitoneal and Intrapleural Routes and their Significance for the Classification of Mineral Fibres. In: Brown, R.C., Hoskins, J.A., Johnson, N.F. (eds) Mechanisms in Fibre Carcinogenesis. NATO ASI Series, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1363-2_48
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