Abstract
Radiobiological hypoxia in malignant tumors has been shown to originate (i) from spatial and temporal functional disturbances of tumor microcirculation resulting in a limited convective O2 flux in microregions even in tissue areas exhibiting high vascular densities, and (ii) from morphological abnormalities of the microcirculatory bed leading to a limitation of the diffusive O2 flux. In addition to these pathogenetic mechanisms, systemic factors (anemia, arterial hypoxia) can also play a role in the development of tumor hypoxia.
Supported by DFG grants Va 57/2–4 and Gr 887/1–1
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© 1988 Plenum Press, New York
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Vaupel, P., Kallinowski, F., Groebe, K. (1988). Evaluation of Oxygen Diffusion Distances in Human Breast Cancer Using Cell Line Specific in Vivo Data: Role of Various Pathogenetic Mechanisms in the Development of Tumor Hypoxia. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_88
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DOI: https://doi.org/10.1007/978-1-4615-9510-6_88
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