Abstract
During arterial hypoxia the brain blood flow rate increases when oxygen tensions below approximately 60 mmHg are attained (Betz, 1972; Grote and Schubert, 1982; Kuschinsky, and Wahl, 1978). Tissue PO2 measurements as well as tissue metabolite assays performed under the same conditions indicate the existence of pronounced tissue hypoxia and the beginning of hypoxic changes in brain metabolism (Grote, Zimmer and Schubert, 1981). Possible mediators of hypoxia-induced cerebral vasodilatation are various metabolic factors, the concentrations of which increase under conditions of insufficient brain oxygen supply. Among these vasodilating factors, potassium and hydrogen ions as well as adenosine seem to play an important role (Betz, 1972; Kuschinsky and Wahl, 1978; Rubio et al., 1985). Different additional vasoactive substances released at low oxygen tensions by the tissue or by the vessel wall itself, especially by the endothelium, are under investigation (Busse et al., 1984; Coburn et al., 1979; Detar, 1980; Eckenfels and Vane, 1972; Fay, 1971; Furchgott and Zawadzki, 1980; Pitman and Duling, 1973; Rubanyi and Vanhoutte, 1985; Rubio et al., 1975; Sparks, Jr. 1980; Vanhoutte, 1976).
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References
Betz, E., 1972, Cerebral blood flow: its measurement and regulation. Physiol. Rev., 52:595–530.
Bolton, T.B., 1979, Mechanisms of action of transmitters and other substances on smooth muscle, Physiol. Rev., 59:606–718
Broadley, K.J., and Rothaul, A.L., 1986, The coronary vasodilator mediator released by hypoxia and isoprenaline is not affected by cyclo-oxygenase inhibition. Prostaglandins, 31:295–306.
Busse, R., Forstermann, U., Matsud, H., and Pohl, U., 1984, The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia. Pflugers Arch. Eur. J. Physiol., 401:77–83
Coburn, R.F., Grubb, S., and Aronson, R.D., 1979, Effect of cyanide on oxygen tension-dependent mechanical tension in rabbit aorta. Circ. Res., 44:368–378.
Detar, R., 1980, Mechanism of physiological hypoxia-induced depression of vascular smooth muscle contraction. Am. J. Physiol., 238:H761–H769.
Eckenfels, A., and Vane, J.R., 1972, Prostaglandins, oxygen tension and smooth muscle tone. Br. J. Pharmacol., 45:451–462.
Fay, F.S., 1971, Guinea pig ductus arteriosus. I. Cellular and metabolic basis for oxygen sensitivity. Am. J. Physiol., 221:470–479.
Furchgott, R.F., and Zawadzki, J.V., 1980, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature. 288:373–376.
Grote, J., Zimmer, K., and Schubert, R., 1981, Effects of severe arterial hypocapnia on regional blood flow regulation, tissue PO2 and metabolism in the brain cortex of cats. Pflugers Arch. Eur. J. Physiol., 391:195–199.
Grote, J., and Schubert, R., 1982, Regulation of cerebral perfusion and PO2 in normal and edematous brain tissue. In: “Oxygen Transport to Human Tissues”, edited by J.A. Loeppky and M.L. Riedesel, pp. 169–178. Elsevier North Holland, Amsterdam, New York, Oxford.
Kuschinsky, W., and Wahl, M., 1978, Local chemical and neurogenic regulation of cerebral vascular resistance. Physiol. Rev. 22:656–689.
Pittman, R.N., and Duling, B.R., 1973, Oxygen sensitivity of vascular smooth muscle. I. In vitro studies. Microvasc. Res. 6:202–211.
Rubanyi, G.M., and Vanhoutte, P.M., 1985, Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium. J. Physiol. (Lond.), 364:45–56.
Rubio, R., Berne, R.M., Bockman, E.L., and Curnish, R.R., 1975, Relationship between adenosine concentration and oxygen supply in rat brain. Am. J. Physiol., 228:1896–1902.
Siegel, G., Ehehalt, R., and Koepchen, H.P., 1978, Membrane potential and relaxation in vascular smooth muscle. in: “Mechanisms of Vaso-dilatation”, edited by P.M. Vanhoutte, and I. Leusen, pp 56–72. S. Karger, Basel, Muchen, Paris, London, New York, Sydney.
Siegel, G., Grote, J., Zimmer, K., Adler, A., and Litza, N., 1986, Electro-physiological effects of hypoxia on vascular smooth muscle. in “Mechanisms of Vasodilatation”, edited by P.M. Vanhoutte, Raven Press, New York, (in press).
Siegel, G., Stock, G., Schnalke, F., and Litza, B., 1986, The effect of iloprost on the electro-mechanical properties of vascular smooth muscle. Pflugers Arch. Eur. J. Physiol., 406:R41.
Siegel, G., Walter, A., Thiel, M., and Ebeling, B.J., 1984, Local regulation of blood floow. Adv. Exp. Med. Biol., 169:515–540.
Sparks, H.V., Jr., 1980, Effect of local metabolic factors on vascular smooth muscle. in: “Handbook of Physiology, Section 2: The Cardio-vascular System, Vol. II: Vascular Smooth Muscle”, edited by D.F. Bohr, A.P. Somlyo, and H.V. Sparks, Jr., pp 475–513. American Physiological Society, Bethesda.
Vanhoutte, P.M., 1976, Effects of anoxia and glucose depletion on isolated veins of the dog. Am. J. Physiol., 230:1261–1268.
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Grote, J., Siegel, G., Zimmer, K., Adler, A. (1988). The Influence of Oxygen Tension on Membrane Potential and Tone of Canine Carotid Artery Smooth Muscle. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_57
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