Abstract
The cerebrospinal fluid (CSF) system, contained within the craniospinal cavities, may be described as a moderately distensible compartment enclosed by the skull and vertebral column, wherein CSF pressure is normally maintained within a relatively narrow range. Transient alterations in volume and flow are compensated by interactions between regulatory mechanisms that involve CSF formation, storage, and outflow. Volumetric expansion within the craniospinal cavities is spatially compensated by a combination of these interacting regulatory factors, which include (1) a compliance factor, defined in terms of volume change per unit change in CSF pressure56, 57, 61, 62 and functionally related to the elastic properties of craniospinal meninges and blood vessels; and (2) an outflow resistance factor that modulates CSF volume by venting fluid through CSF outflow sites into the venous circulation.
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References
Adams, J. E., Prawirohardjo, S.: Fate of red blood cells injected into cerebrospinal fluid pathways. Neurology (Minneapolis)9: 561–564, 1959.
Alksne, J. F., White, L. E.: Electron microscope study of the effect of increased intracranial pressure on the arachnoid villus. J. Neurosurg. 22: 481, 1965.
Alksne, J. F., Lovings, E. T.: Functional ultrastructure of the arachnoid villus. Arch. Neurol. Psychiatry27: 371–377, 1972.
Alksne, J. F., Lovings, E. T.: The role of the arachnoid villus in the removal of red blood cells from the subarachnoid space: An electron microscope study in the dog. J. Neurosurg. 36: 192, 1972.
Andres, K. H.: Zur Feinstruktur der arachnoidal Zotten bei Mammalia. Z. Zellforsch. Mikrosk. Anat. 82: 92–109, 1967.
Bagley, C., Jr.: Blood in the cerebrospinal fluid: Resultant functional and organic alterations in the central nervous system. A. Experimental data. Arch. Surg. (Chicago)17: 18–38, 1928.
Bagley, C., Jr.: Blood in the cerebrospinal fluid: Resultant functional and organic alterations in the central nervous system. B. Clinical data. Arch. Surg. (Chicago)17: 39–81, 1928.
Bamford, C. R., Labadie, E. L.: Reversal of dementia in normotensive hydrocephalus after removal of a cauda equina tumor: Case report. J. Neurosurg. 45: 104–107, 1976.
Bradford, F. K., Johnson, P. C.: Passage of intact iron-labeled erythrocytes from subarachnoid space to systemic circulation in dogs. J. Neurosurg. 19: 332–336, 1962.
Bradford, F., Sharkey, P.: Physiologic effects from introduction of blood and other substances into the subarachnoid space of dogs. J. Neurosurg. 19: 1017–1022, 1962.
Brightman, M. W., Reese, T. S.: Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol. 40: 648–677, 1969.
Brightman, M. W.: Morphology of blood brain interfaces. In Bito, L. Z., Davson, H., Fenstermacher, J. D. (eds.): The Ocular and Cerebrospinal Fluids. Exp. Eye Res. 24(Suppl.):l-25, 1977.
Butler, A. B., Maffeo, C. J., Johnson, R. N., Bass, N. H.: Impaired absorption of CSF during experimental subarachnoid hemorrhage: Effects of blood components on vesicular transport in arachnoid villi. In Shulman, K., Marmarou, A., Miller, J. D., Hochward, G., Becker, D. B., Brock, M. (eds.): Intracranial Pressure IV. Berlin, Heidelberg, New York, Springer-Verlag, 1980, pp. 245–248.
Butler, A. B., Mann, J. D., Falk, P. M., Johnson, R. N., Bass, N. H.: Pressure-sensitive vesicular transport of cerebrospinal fluid through the arachnoid villus endothelium J. Comp. Neurol. (in press).
Butler, A. B., Mann, J. D., Falk, P. M., Johnson, R. N., Bass, N. H.: Pressure-sensitive protein transport by vesicles in arachnoid villus endothelium (submitted).
Cleland, P. G., Macfarlane, J. T., Baird, D. R., Greenwood, B. M.: Fibrin degradation products in the cerebrospinal fluid of patients with pneumococcal meningitis. J. Neurol. Neurosurg. Psychiatry42: 843–846, 1979.
Courtice, F. C., Simmonds, W. J.: The removal of protein from the subarachnoid space. Aust. J. Exp. Biol. Med. Sci. 29: 255–263, 1951.
Cushing, H.: Studies on cerebrospinal fluid. I. Introduction. J. Med. Res. 31: 1–19, 1914.
Dacey, R. G., Welsh, J. E., Winn, H. R., Scheld, W. M., Sande, M. A., Jane, J. A.: Bacterial meningitis: Changes in CSF outflow resistance. In Shulman, K., Marmarou, A., Miller, J. D., Hochward, G., Becker, D. B., Brock, M. (eds.): Intracranial Pressure IV. Berlin, Heidelberg, New York, Springer-Verlag, 1980, pp. 350–353.
Davson, H.: The rate of disappearance of substances injected into the subarachnoid space of rabbits. J. Physiol. 128: 52–53, 1955.
Davson, H.: Dynamic aspects of cerebrospinal fluid. Cerebral Palsy Bull. 14(Suppl. 27): 1–16, 1972.
Davson, H., Kleeman, C. R., Levin, E.: Quantitative studies of the passage of different substances out of the cerebrospinal fluid. J. Physiol. 161: 126–142, 1962.
Davson, H., Hollingsworth, J., Segal, M. D.: The mechanism of drainage of the cerebrospinal fluid. Brain93: 665–678, 1970.
Davson, H., Domer, F. R., Hollingsworth, J. R.: The mechanism of drainage of the cerebrospinal fluid. Brain96: 329–336, 1973.
Davson, H.: Porous nature of the absorptive mechanism. In Lundberg, N., Ponten, U., Brock, M., (eds.): Intracranial Pressure II. Berlin, New York, Springer-Verlag, 1975, pp. 28–34.
Deland, F. H., James, A. E., Jr., Ladd, D. J., Kon-Igsmark, B. W.: Normal pressure hydrocephalus: A histologic study. Am. J. Clin. Pathol. 58: 58–63, 1972.
Denny-Brown, D. E.: Changing patterns of neurologic medicine. N. Engl. J. Med. 246: 839–846, 1952.
Dupont, J. R., van Wart, C. A., Kraintz, L.: The clearance of major components of whole blood from cerebrospinal fluid following simulated subarachnoid hemorrhage. J. Neuropathol. Exp. Neurol. 20: 450–455, 1961.
Ellington, E., Margolis, G.: Block of arachnoid villus by subarachnoid hemorrhage. J. Neurosurg. 30: 651–657, 1969.
Gardner, W. J., Spitler, D. K., Whitten, C.: Increased intracranial pressure caused by increased protein content in the CSF: An explanation of papilledema in certain cases of small intracranial and intraspinal tumors and in the Guillain-Barré syndrome. N. Engl. J. Med. 250: 932–936, 1954.
Gilles, F. H., Davidson, R. I.: Communicating hydrocephalus associated with deficient dysplastic parasagittal arachnoid granulations. J. Neurosurg. 35: 421–426, 1971.
Gomez, D. G., Potts, D. G., Deonarine, V., Reilly, K. F.: Effects of pressure gradient changes on the morphology of arachnoid villi and granulations of the monkey. Lab. Invest. 28: 648–657, 1973.
Gomez, D. G., Potts, D. G., Deonarine, V.: Arachnoid granulations of the sheep: Structural and ultrastructural changes with varying pressure differences. Arch. Neurol. 30: 169–175, 1974.
Gomez, D. G., Potts, D. G.: The surface characteristics of arachnoid granulations. Arch. Neurol. 31: 88–93, 1974.
Grierson, I., Lee, W. R.: Pressure-induced changes in the ultrastructure of the endothelium lining Schlemm’s canal. Am. J. Ophthalmol. 80: 863–884, 1975.
Gutierrez, Y., Friede, R. L., Kaliney, W. J.: Agenesis of arachnoid granulations and its relationship to communicating hydrocephalus. J. Neurosurg. 43: 553–558, 1975.
Hammes, E.: Reaction of meninges to blood. Arch. Neurol. Psychiatry52: 505–514, 1944.
Hansson, H.-E., Johnsson, B., Blomstrand, C.: Ultrastructural studies on cerebrovascular permeability in acute hypertension. Acta Neuropathol. 32: 187–198, 1975.
Hayashi, M., Marukawa, S., Fujii, H., Kobayashi, H., Yamamoto, S.: Intracranial hypertension in acute stage of ruptured intracranial aneurysms. In Beks, J. W. F., Bosch, D. A., Brock, M. (eds.): Intracranial Pressure II. Berlin, Heidelberg, New York, Springer-Verlag, 1976, pp. 162–167.
Intaglietta, M., Deplomb, E. P.: Fluid exchange in tunnel and tube capillaries. Microvasc. Res. 6: 153–168, 1973.
Ishii, M., Suzuki, S., Julow, J.: Subarachnoid hem-orrhage and communicating hydrocephalus: Scanning electron microscopic observations. Acta Neu-rochir. 50: 265–272, 1979.
Jackson, I. J.: Aseptic hemogenic meningitis: Experimental study of aseptic meningeal reactions due to blood and its breakdown products. Arch. Neurol. Psychiatr. 62: 572–589, 1949.
James, A. E., Jr., Mccomb, J. G., Christian, J., Dav-Son, H.: The effect of cerebrospinal fluid pressure on the size of drainage pathways. Neurology26: 659–663, 1976.
Jayatilaka, A. D. P.: Arachnoid granulations in sheep. J. Anat. 99: 315–327, 1965.
Jayatilaka, A. D. P.: An electron microscopic study of sheep arachnoid granulations. J. Anat. 99: 635–649, 1965.
Johansson, B. R.: Permeability of muscle capillaries to interstitially microinjected horseradish peroxidase. Microvasc. Res. 16: 340–353, 1978.
Johnson, R. N., Maffeo, C. J., Butler, A. B., Mann, J. D., Bass, N. H.: Intracranial hypertension in experimental animals and man: Quantitative approach to system dynamics of circulatory cerebrospinal fluid. In Wood, J. H. (ed.): Neurobiology of Cerebrospinal Fluid2. New York, Plenum Press, 1983, Chapter 44.
Johnson, R. N., Maffeo, C. J., Mann, J. D., Butler, A. B., Bass, N. H.: A comparative model of cerebrospinal fluid systems. Life Sci. 8: 79–92, 1978.
Johnson, R. N., Maffeo, C. J., Dacey, R. G., Butler, A. B., Bass, N. H.: Mechanism for intracranial hypertension during experimental subarachnoid hemorrhage: Acute malfunction of arachnoid villi by components of plasma. Trans. Am. Neurol. Assoc. 103: 138–142, 1978.
Johnstone, M. A., Grant, W. M.: Pressure-dependent changes in structures of the aqueous outflow system of human and monkey eyes. Am. J. Ophthalmol. 75: 365–383, 1973.
Julow, J., Ishii, M., Iwabuchi, I.: Scanning electron microscopy of the subarachnoid macrophages after subarachnoid hemorrhage, and their possible role in the formation of subarachnoid fibrosis. Acta Neu-rochir. 50: 273–280, 1979.
Julow, J., Ishii, M., Iwabuchi, T.: Arachnoid villi affected by subarachnoid pressure and hemorrhage: Scanning electron microscopic study in the dog. Acta Neurochir. 51: 63–72, 1979.
Kaufman, H. H., Carmel, P. W.: Aseptic meningitis and hydrocephalus after posterior fossa surgery. Acta Neurochir. 44: 179–196, 1978.
Key, A., Retzius, G.: Anatomie des Nervensystems und des Bindegewebes, Vol. I. Stockholm, P. A., Nord-stedt, 1875.
Kolberg, T., Palma, A.: New aspects of cerebrospinal fluid dynamics in humans investigated by sequential gamma camera cisternography, with data evaluation by the digital multichannel ana-lyzer. 2. Pathology of cerebrospinal fluid flow in the subarachnoid space of the brain convexity. Acta Neurochir. 38: 1–12, 1977.
Legros, Clark, W. E.: On the Pacchionian bodies. J. Anat. 55: 40–48, 1920.
Lofgren, J., Von Essen, C., Zwetnow, N. N.: The pressure-volume curve of the cerebrospinal fluid space in dogs. Acta Neurol. Scand. 49: 557–574, 1973.
Lofgren, J., Zwetnow, N. N.: Cranial and spinal components of the cerebrospinal fluid pressure volume curve. Acta Neurol. Scand. 49: 575–585, 1973.
Lorenzo, A. V., Bresnan, M. J., Barlow, C. F.: Cerebrospinal fluid absorption deficit in normal pressure hydrocephalus. Arch. Neurol. 30: 387–393, 1974.
Mann, J. D., Butler, A. B., Rosenthal, J., Maffeo, C. J., Johnson, R. N., Bass, N. H.: Regulation of intracranial pressure in rat, dog, and man. Ann. Neurol. 3: 156–165, 1978.
Mann, J. D., Butler, A. B., Johnson, R. N., Bass, N. H.: Clearance of macromolecular and particulate substances from the cerebrospinal fluid system of the rat. J. Neurosurg. 50: 343–348, 1979.
Marmarou, A., Shulman, K., Lamorgese, J.: Com-partmental analysis of compliance and outflow resistance of the cerebrospinal fluid system. J. Neurosurg. 43: 523–534, 1975.
Marmarou, A., Shulman, K., Rosende, R. M.: A non-linear analysis of the cerebrospinal fluid system and intracranial pressure dynamics. J. Neurosurg. 48: 332–344, 1978.
Matthews, W. F., Frommeyer, W. B.: The in vitro behavior of erythrocytes in human cerebrospinal fluid.J. Lab. Clin. Med. 45: 508–515, 1955.
Mcqueen, J. D., Jelsma, L. F.: Intracranial hypertension: Cerebrospinal fluid pressure rises following intracisternal infusions of blood components in dogs. Arch. Neurol. 16: 501–508, 1967.
Mcqueen, J. D., Northrup, B. E., Leibrock, L. G.: Arachnoid clearance of red blood cells. J. Neurol. Neurosurg. Psychiatry37: 1316–1321, 1974.
Nabeshima, S., Reese, T. S., Landis, D. M. D., Brightman, M. W.: Junctions in the meninges and marginal glia. J. Comp. Neurol. 164: 127–169, 1975.
Nornes, H., Magnaes, B.: Intracranial pressure in patients with ruptured saccular aneurysm. J. Neurosurg. 36: 537–647, 1972.
Pacchioni, A.: Dissertation epistolaris and lucam schroeckium de glandulis conglobatis durae meningis il-umanae. Rome, 1705.
Palade, G. E., Bruns, R. R.: Structural modulation of plasmalemmal vesicles. J. Cell Biol. 37: 633–649, 1968.
Potts, D. B., Reilly, K. F., Deonarine, V.: Morphology of the arachnoid villi and granulations. Radiology105: 333–341, 1972.
Potts, D. G., Gomez, D. F.: Cerebrospinal fluid-production, function and absorption. In Newton, T. H., Potts, D. G., (eds.): Radiology of the Skull and Brain, Vol. III. St. Louis, C. V. Mosby, 1977, pp. 2915–2937.
Prockop, L. D., Schanker, L. S., Brodie, B. B.: Passage of lipid-insoluble substances from cerebrospinal fluid to blood. J. Pharmacol135: 266–270, 1962.
Reese, T. S., Karnovsky, M. J.: Fine structural localization of a blood-brain barrier to exogenous peroxidase. J. Cell Biol. 34: 207–217, 1967.
Roost, K. T., Pimstone, N. R., Diamond, I., Schmid, R.: The formation of cerebrospinal fluid xanthochromia after subarachnoid hemorrhage: Enzymatic conversion of hemoglobin to bilirubin by the arachnoid and choroid plexus. Neurology22: 973–977, 1972.
Schemm, C., Bentley, J., Doerfler, M.: Wound healing in the subarachnoid space. Neurology18: 862–869, 1968.
Shabo, A. L., Maxwell, D. S.: The morphology of the arachnoid villi: A light and electron microscopic study in the monkey. J. Neurosurg. 29: 451–463, 1968.
Shabo, A. L., Maxwell, D. S.: Electron microscopic observations on the fate of particulate matter in the cerebrospinal fluid. J. Neurosurg. 29: 464–474, 1968.
Shabo, A. L., Abbott, M. M., Maxwell, D. S.: The response of the arachnoid villus to an intracisternal injection of autogenous brain tissue: An electron microscopic study in the macaque monkey. Neurology19: 724–734, 1969.
Shabo, A. L., Maxwell, D. S.: The subarachnoid space following the introduction of a foreign protein: An electron microscopic study with peroxidase. J. Neuropathol. Exp. Neurol. 30: 506–524, 1971.
Shabo, A. L., Brightman, M. W.: Permeability to peroxidase of the endothelium in the arachnoid villus of monkeys. Anat. Rec. 172: 404, 1972.
Shirley, H. H., Wolfram, C. G., Wasserman, K., Mayerson, H. S.: Capillary permeability to macro-molecules: Stretched pore phenomenon. Am. J. Physiol. 190: 189–193, 1957.
Simionescu, N., Simionescu, M., Palade, G. E.: Permeability of muscle capillaries to small heme-peptides: Evidence for the existence of patent transendothelial channels. J. Cell Biol. 64: 586–607, 1975.
Simionescu, M., Simionescu, N., Palade, G. E.: Segmental differentiations of cell junctions of the vascular endothelium: The microvasculature. J. Cell Biol. 67: 863–885, 1975.
Simionescu, N., Simionescu, M., Palade, G. E.: Structural basis of permeability in sequential segments of the microvasculature of the diaphragm. II. Pathways followed by microperoxidase across the endothelium. Microvasc. Res. 15: 17–36, 1978.
Simmonds, W. J.: The absorption of blood from the cerebrospinal fluid in animals. Aust. J. Exp. Biol. Med. Sci. 30: 261–270, 1952.
Simmonds, W. J.: The absorption of labelled eryth-rocytes from the subarachnoid space in rabbits. Aust. J. Exp. Biol. Med. Sci. 31: 77–84, 1953.
Steiner, L., Lofgren, J., Zwetnow, N. M.: Characteristics and limits of tolerance in repeated subarachnoid hemorrhage in dogs. Acta Neurol. Scand. 52: 241–267, 1975.
Steiner, L., Lofgren, J., Zwetnow, N. M.: Lethal mechanism in repeated subarachnoid hemorrhage in dogs. Acta Neurol. Scand. 52: 268–293, 1975.
Sundbarg, G., Ponten, U.: ICP and CSF absorption impairment after subarachnoid hemorrhage. In Beks, J. W. F., Bosch, D. A., Brock, M. (eds.): Intracranial Pressure II. Berlin, Heidelberg, New York, Springer-Verlag, 1976, pp. 139–146.
Suzuki, S., Ishii, M., Ottomo, M., Iwabuchi, T.: Changes in the subarachnoid space after experimental subarachnoid hemorrhage in the dog: Scanning electron microscopic observation. Acta Neuro-chir. 39: 1–14, 1977.
Suzuki, S., Ishii, M., Iwabuchi, T.: Post-haemor-rhagic subarachnoid fibrosis in dogs: Scanning electron microscopic observation and dye perfusion study. Acta Neurochir. 46: 105–117, 1979.
Torvik, A., Bhatia, R., Murthy, V. S.: Transitory block of the arachnoid granulations following subarachnoid hemorrhage. Acta Neurochir. 41: 137–146, 1978.
Tripathi, R.: Tracing the bulk outflow route of cerebrospinal fluid by transmission and scanning electron microscopy. Brain Res. 80: 503–506, 1974.
Tripathi, R. C.: The functional morphology of the outflow systems of ocular and cerebrospinal fluids. In Bito, L. Z., Davson, H., Fenstermacher, J. D. (eds.): The Ocular and Cerebrospinal Fluids. Exp. Eye Res. 24(Suppl.): 65–116, 1977.
Tripathi, R., Tripathi, B.: Vacuolar transcellular channels as the drainage pathways of cerebrospinal fluid. J. Physiol. 239: 195–206, 1974.
Turner, L.: The structure and relationships of the arachnoid granulations. In Wolstenholme, G. E. W., O’Conner, C. M. (eds.): Ciba Foundation Symposium on the Cerebrospinal Fluid. London, I. and A. Churchill, 1958, pp. 32–54.
Turner, L.: The structure of arachnoid granulations with observations on their physiological and pathological significance. Ann. R. Coll. Surg. 29: 237–264, 1961.
Vandeurs, B.: Vesicular transport of horseradish peroxidase from brain to blood in segments of the cerebral microvasculature in adult mice. Brain Res. 124: 1–8, 1977.
Vandeurs, B., Moller, M., Amtorp, O.: Uptake of horseradish peroxidase from CSF into the choroid plexus of the rat, with special reference to trans-epithelial transport. Cell Tissue Res. 187: 215–234, 1978.
Vessal, K., Sperber, E. E., James, A. E., Jr.: Chronic communicating hydrocephalus with normal CSF pressures: A cisternographic-pathologic correlation. Ann. Radiol17: 785–793, 1974.
Waggener, J. D., Beggs, J.: The membranous coverings of neural tissues: An electron microscopic study. J. Neuropathol. Exp. Neurol. 26: 412–425, 1967.
Wagner, H.-J., Pilgrim, C., Brandl, J.: Penetration and removal of horseradish peroxidase injected into the cerebrospinal fluid: Role of cerebral perivascular spaces, endothelium and microglia. Acta Neuropathol. 27: 299–315, 1974.
Weed, L. H.: Studies in cerebrospinal fluid. II. The theories of drainage of cerebrospinal fluid with an analysis of the methods of investigation. J. Med. Res. 31: 21–49, 1914.
Weed, L. H.: Studies on cerebrospinal fluid. III. The pathways of escape from the subarachnoid spaces with particular reference to the arachnoid villi. J. Med. Res. 31: 51–91, 1914.
Weed, L. H.: An anatomical consideration of the cerebrospinal fluid. Anat. Rec. 12: 461–496, 1917.
Weed, L. H.: The absorption of cerebrospinal fluid into the venous system. Am. J. Physiol. 31: 191–221, 1923.
Weed, L. H., Flexner, L. B., Clark, J. H.: The effect of dislocation of cerebrospinal fluid upon its pressure. Am. J. Physiol. 100: 246–261, 1932.
Weed, L. H.: Forces concerned in the absorption of the cerebrospinal fluid. Am. J. Anat. 114: 40–45, 1935.
Welch, K., Friedman, V.: The cerebrospinal fluid valves. Brain83: 454, 1960.
Welch, K., Pollay, M.: Perfusion of particles through arachnoid villi of the monkey. Am. J. Physiol. 201: 651–654, 1961.
Westergaard, E., Vandeurs, B., Broadsted, H. E.: Increased vesicular transfer of horseradish peroxidase across cerebral endothelium, evoked by acute hypertension. Acta Neuropathol. 37: 141–152, 1977.
Williams, M. D., Wissig, S. L.: The permeability of muscle capillaries to horseradish peroxidase. J Cell Biol. 66: 531–555, 1975.
Winkelman, N. W., Fay, T.: The Pacchionian system: Histologic and pathologic changes with particular reference to the idiopathic and symptomatic convulsive states. Arch. Neurol. Psychiatry23: 44–64, 1930.
Wolff, J.: On the meaning of vesiculation in capillary endothelium. Angiologica4: 64–68, 1967.
Wolff, J. R.: Ultrastructure of the terminal vascular bed as related to function. In Kaley, G., Altura, B. M. (eds.): Microvascular Circulation, Vol. I. Baltimore, London, Tokyo, University Park Press, 1977, pp. 95–130.
Wolfson, L. I., Katzman, R.: Infusion manometric test in experimental subarachnoid hemorrhage in cats. Neurology22: 856–862, 1972.
Yasargil, M. D., Yonekawa, Y., Zumstein, B., Stahl, H.-J.: Hydrocephalus following spontaneous subarachnoid hemorrhage. J. Neurosurg. 39: 474–479, 1973.
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Butler, A.B., Dacey, R.G., Maffeo, C.J., Mann, J.D., Johnson, R.N., Bass, N.H. (1983). Mechanisms of Cerebrospinal Fluid Absorption in Normal and Pathologically Altered Arachnoid Villi. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9269-3_45
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