Abstract
It is well recognized that naturally occurring diseases of animals can provide insights into the causal mechanisms, pathogenesis, and therapy of human disease.37,55,75,117,170,224 Animal models are particularly useful in the study of genetic disorders, in which the chain of events between the underlying cause and the pathologic phenotype is difficult or impossible to study in man (e.g., pathogenesis of congenital malformations), or in which evaluation of therapy requires a whole mammalian organism (e.g., enzyme replacement therapy in metabolic disease). Since accurate models of genetic disorders cannot be readily produced by experimental manipulation of normal laboratory animals, genetically determined counterparts of human disease in animals offer the most plausible alternative.
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Patterson, D.F., Haskins, M.E., Jezyk, P.F. (1982). Models of Human Genetic Disease in Domestic Animals. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8315-8_4
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