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Fish vaccine: development, production and use of bacterial vaccines, with special reference to salmon

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Fisheries Processing

Abstract

A limiting factor in cultivation of Atlantic salmon (Salmo salar L.) and other fish species has been diseases. Apart from furunculosis and bacterial kidney disease (BKD) in salmon, vibrio infections are by far the most serious problem in aquaculture. If attacked by a pathogen, the fish may develop a disease as illustrated in Figure 17.1. To combat diseases vaccination has been a great success in human and veterinary medicine. In aquaculture the use of vaccines is still in an early developing phase and, as reviewed by Ellis (1988a), it is mainly vaccines against bacterial infections like vibriosis, cold water vibriosis, yersiniosis and furunculosis that have given convincing protection in field trials. Vaccines against other diseases have been less effective, side effects have occurred, and some vaccines have been too expensive both to develop and produce. However, the economical losses due to cold water vibriosis and vibriosis in salmon aquaculture amounted to more than US$ 100 million during the period 1984–1988 in Norway (Tilseth, Hansen and Møller, 1991), which justifies a rather high price for fish vaccines, if effective. Research into and development of fish vaccines are in our opinion necessary for a healthy aquaculture industry in the future.

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References

  • Actam, A., Auchinachie, N., Bundy, A. et al. (1988) The potency of adjuvanted injected vaccines in Rainbow trout (Salmo gairdneri Richardson) and bath vaccines in Atlantic salmon (Salmo salar L.) against furunculosis. Aquaculture, 69, 15–26.

    Article  Google Scholar 

  • Amend, D.F. (1981) Potency testing of fish vaccines. Dev. Biol. Standard., 49, 447–454.

    Google Scholar 

  • Anderson, J.W. and Conroy, D.A. (1970) Vibrio diseases in fishes, in A Symposium on Diseases of Fishes and Shellfishes, (ed. S.F. Snieszko), American Fisheries Society, Washington, Special Publication 5, 226–272.

    Google Scholar 

  • Austin, B. (1985) Evaluation of antimicrobial compounds for the control of bacterial kidney disease in rainbow trout, Salmo gairdneri Richardson. J. Fish Dis., 8, 209–220.

    Article  Google Scholar 

  • Austin, B. and Allen-Austin, D. (1985) A review. Bacterial pathogens of fish. J. Appl. Bacteriol., 58, 483–506.

    Article  CAS  Google Scholar 

  • Austin, B. and Austin, D.A. (1987) Bacterial Fish Pathogens: Disease in Farmed and Wild Fish, Ellis Horwood, New York.

    Google Scholar 

  • Baudin-Laurencin, F. and Tangtrongpiros, J. (1980) Some results of vaccination against vibriosis in Brittany, in Fish Diseases, (ed. W. Ahne), Springer-Verlag, Berlin, pp. 60–68.

    Chapter  Google Scholar 

  • Bruno, D.W. (1986) Histopathology of bacterial kidney disease in laboratory infected rainbow trout, Salmo gairdneri Richardson, and Atlantic salmon, Salmo salar L., with reference to naturally infected fish. J. Fish Dis., 9, 523–537.

    Article  Google Scholar 

  • Bullock, G.L., Stuckey, H.M. and Shotts, E.B. (1978) Enteric redmouth bacterium: comparison of isolates from different geographical areas. J. Fish Dis., 1, 351–354.

    Article  Google Scholar 

  • Bullock, G.L. and Anderson, D.P. (1984) Immunization against Yersinia ruckeri, cause of enteric redmouth disease, in Symposium on Fish Vaccination; Theoretical Background and Practical Results on Immunization against Infectious Diseases, (ed. P. De Kinkelin), Office International des Epizooties, Paris, pp. 151–166.

    Google Scholar 

  • Busch, R.A. (1973) The serological surveillance of salmonoid populations for presumtive evidence of specific disease association. PhD Dissertation, University of Idaho.

    Google Scholar 

  • Ceschia, G., Giorgetti, G., Bertoldini, G. and Fontebasso, S. (1987). The in vitro sensitivity of Yersinia ruckeri to specific antibiotics. J. Fish Dis., 10, 65–67.

    Article  CAS  Google Scholar 

  • Corbel, M.J. (1975) The immune response in fish: a review. J. Fish Biol., 7, 539–563.

    Article  Google Scholar 

  • Cossarini-Dunier, M. (1985) Effect of different adjuvants on the humoral immune response of rainbow trout. Dev. Comp. Immunol., 9, 141–146.

    Article  CAS  Google Scholar 

  • Crosa, J.H. (1980) A plasmid associated with virulence in the marine fish pathogen Vibrio anguillarum specifies an iron-sequestering system. Nature, 283, 566–568.

    Article  Google Scholar 

  • Crosa, J.H., Schiewe, M.H. and Falkow, S. (1977) Evidence for plasmid contribution to the virulence of the fish pathogen Vibrio anguillarum. Infect. Immun., 27, 509–513.

    Google Scholar 

  • Earp, B.J. (1950) Kidney Disease in Young Salmon. MSc Thesis, University of Washington.

    Google Scholar 

  • Egidius, E., Andersen, K., Clausen, E. and Raa, J. (1981). Cold-water vibriosis or ‘Hitra disease’ in Norwegian salmonoid farming. J. Fish Dis., 4, 353–354.

    Article  Google Scholar 

  • Egidius, E., Wiik, R., Andersen, K. et al. (1986) Vibrio salmonicida sp. nov., a new fish pathogen. Int. J. Syst. Bacteriol., 36, 518–520.

    Article  Google Scholar 

  • Ellis, A.E. (ed.)(1988a) Fish Vaccination, Academic Press, New York.

    Google Scholar 

  • Ellis, A.E. (1988b) General principles of fish vaccination, in Fish Vaccination, (ed. A.E. Ellis), Academic Press, New York, pp. 1–19.

    Google Scholar 

  • Ellis, A.E. (1989) The immunology of teleosts, in Fish Pathology, (ed. R.J. Roberts), Baillière Tindall, London, pp. 135–152.

    Google Scholar 

  • Fletcher, T.C. (1982) Non-specific defence mechanisms of fish. Dev. Comp. Immunol. Suppl., 2, 123–132.

    Google Scholar 

  • Fryer, J.L. and Sanders, J.E. (1981) Bacterial kidney disease of salmonoid fish. Ann. Rev. Microbiol., 35, 273–298.

    Article  CAS  Google Scholar 

  • Gilmore, R.D., Engelking, H.M., Manning, D.S. and Leong, J.C. (1988) Expression in E. coli of an epitope of the glycoprotein of infectious haematopoietic necrosis virus protects against viral challenge. Bio/Technology, 6, 295–300.

    Article  CAS  Google Scholar 

  • Hoffman, R., Popp, W. and van der Graaff, S. (1984) Atypical BKD predominantly causing ocular and skin lesions. Bull. Eur. Ass. Fish Pathol., 4, 7–9.

    Google Scholar 

  • Holm, K.O., Strøm, E., Stenvåg, K., Raa, J. and Jørgensen, T. (1985) Characteristics of a Vibrio sp. associated with the ‘Hitra disease’ of Atlantic salmon in Norwegian fish farms. Fish Pathol., 20, 125–129.

    Article  Google Scholar 

  • Holm, K.O. and Jørgensen, T. (1987) A successful vaccination of Atlantic salmon, Salmo solar L., against ‘Hitra disease’ or coldwater vibriosis. J. Fish Dis., 10, 85–90.

    Article  Google Scholar 

  • Home, M.T., Roberts, R.J., Tatner, M. and Ward, P. (1984) The effects of the use of potassium alum adjuvant in vaccines against vibriosis in rainbow trout, Salmo gairdneri Richardson. J. Fish Dis., 7, 91–99.

    Article  Google Scholar 

  • Hunter, V.A., Knittel, M.D. and Fryer, J.L. (1980) Stress-induced transmission of Yersinia ruckeri infection from carriers to recipient steelhead trout Salmo gairdneri Richardson. J. Fish Dis., 3, 467–472.

    Article  Google Scholar 

  • Ingram, G.A. (1980) Substances involved in the natural resistance of fish to infection — a review. J. Fish Biol., 16, 23–60.

    Article  CAS  Google Scholar 

  • Knappskog, D.H., Rødseth, O.M., Slinde, E, and Endresen, C. (1993) Immunochemical analyses of Vibrio anguillarum strains isolated from cod (Gadus morhua L.) suffering from vibriosis. J. Fish Dis., 16, 327–338.

    Article  Google Scholar 

  • Koener, J.F., Passavant, C.W., Kurah, G. and Leong, J.C. (1987) Nucleotide sequence of cDNA clone carrying the glycoprotein gene of infectious haematopoietic necrosis virus, a fish rhabdovirus. J. Virol., 61, 1342–1349.

    CAS  Google Scholar 

  • Krantz, G.E., Reddecliff, J.M. and Heist, C.E. (1964) Immune response of trout to Aeromonas salmonicida. Part 1. Development of agglutinating antibodies and protective immunity. Progressive Fish Culturist, 26, 3–10.

    Article  CAS  Google Scholar 

  • Kurath, G., Ahern, K.G., Pearson, G.D. and Leong, J.C. (1985). Molecular cloning of the six mRNA species of the infectious haematopoietic necrosis virus, a fish rhabdovirus, and gene order determination by R-loop mapping. J. Virol., 53, 469–476.

    CAS  Google Scholar 

  • Leong, J.C., Fryer, J.L. and Winton, J.R. (1988) Vaccination against infectious haematopoietic necrosis, in Fish Vaccination, (ed. A.E. Ellis), Academic Press, New York pp. 193–203.

    Google Scholar 

  • Leong, J.A. and Munn, C.B. (1991) Potential use of recombinant DNA in the development of fish vaccines. Bull. Eur. Ass. Fish Pathol., 1, 30–40.

    Google Scholar 

  • Lillehaug, A. (1989) Oral immunization of rainbow trout, Salmo gairdneri Richardson, against vibriosis with vaccines protected against digestive degradation. J. Fish Dis., 12, 579–584.

    Article  Google Scholar 

  • Lillehaug, A., Ramstad, A., Bækken, K. and Reitan, L.J. (1993) Protective immunity in Atlantic salmon (Salmo solar L.) vaccinated at different water temperatures. Fish and Shellfish Immunol., 3, 143–156.

    Article  Google Scholar 

  • McCarthy, D.H. (1975). Fish furunculosis. J. Inst. Fish. Management, 6, 13–18.

    Google Scholar 

  • McCarthy, D.H. and Roberts, R.J. (1980). Furunculosis of fish — the present state of our knowledge, in Advances in Aquatic Microbiology, (eds M. A. Droop and H.W. Jannasch), Academic Press, London, pp. 293–341.

    Google Scholar 

  • Mackie, T.J., Arkwright, A.J., Pryce-Tannatt, T.E. et al. (1933) Second Interim Report of the Furunculosis Committee, HMSO, Edinburgh.

    Google Scholar 

  • Manning, D.S. (1988) Deletion mapping and expression of the large genomic segment of infectious pancreatic necrosis virus. Doctoral Thesis, Oregon State University.

    Google Scholar 

  • Manning, M.J. and Mugal, M.S. (1985) Factors affecting the immune responses of immature fish, in Fish and Shellfish Pathology, (ed. A.E. Ellis), Academic Press, London, pp. 27–40.

    Google Scholar 

  • O’Leary, P.J. (1977) Enteric redmouth of salmonids: a biochemical and serological comparison of selected isolates. MS thesis, Oregon State University.

    Google Scholar 

  • Paterson, W.D. and Fryer, J.L. (1974) Immune response of juvenile coho salmon (Oncorhynchus kisutch) to Aeromonas salmonicida cells administered intraperitoneally in Freund’s complete adjuvant. J. Fish. Res. Board Can., 31, 1751–1755.

    Article  Google Scholar 

  • Robertsen, B., Rørstad, G., Engstad, R. and Raa, J. (1990) Enhancement of nonspecific disease resistance in Atlantic salmon, Salmo salar L., by a glucan from Saccharomyces cerevisiae cell walls. J. Fish Dis., 13, 391–400.

    Article  CAS  Google Scholar 

  • Rodgers, C.J. and Austin, B. (1982) Oxolinic acid for control of enteric redmouth disease in rainbow trout. Veterinary Record, 112, 83.

    Article  Google Scholar 

  • Ross, A.J., Rucker, R.R. and Ewing, W.H. (1966) Description of a bacterium associated with redmouth disease of rainbow trout (Salmo gairdneri). Can. J. Microbiol. 12, 763–770.

    Article  CAS  Google Scholar 

  • Rucker, R.R. (1966) Redmouth disease of rainbow trout (Salmo gairdneri). Bulletin de l’Office International des Epizooties, 65, 825–830.

    CAS  Google Scholar 

  • Rørstad, G., Aasjord, P. and Robertsen, B. (1992) Adjuvant effect of a yeast glucan in vaccination against furunculosis in Atlantic salmon (Salmo salar L.). Fish Shellfish Immunol., 3, 179–190.

    Article  Google Scholar 

  • Sanders, J.E. and Fryer, J.L. (1980) Renibacterium salmoninarum gen. nov., the causative agent of bacterial kidney disease in salmonoid fishes. Int. J. Syst. Bacteriol., 30, 496–502.

    Article  CAS  Google Scholar 

  • Schubert, R.H.W. (1974) Genus II. Aeromonas Kluyver and van Niel 1936, 398, in Bergey’s Manual of Determinative Bacteriology, 8th edn, (eds R.E. Buchanan and N.E. Gibbons), Baltimore, Williams and Wilkins, pp. 345–348.

    Google Scholar 

  • Smith, I.W. (1964) The occurrence and pathology of Dee disease. Dept. Agric. Fish. Scot. Freshwater and Salmon Fisheries Research 34, HMSO, Edinburgh.

    Google Scholar 

  • Snieszko, S.F. (1957) Genus IV. Aeromonas (Kluyver and van Niel, 1936). In Bergey’s Manual of Determinative Bacteriology, 7th edn, (eds R.S. Breed, E.G.D. Murray and N.R. Smith), Baltimore, Williams and Wilkins, pp. 189–193.

    Google Scholar 

  • Snieszko, S.F. and Griffin, P.J. (1955) Kidney disease in brook trout and its treatment. Progressive Fish Culturist, 17, 3–13.

    Article  CAS  Google Scholar 

  • Stevenson, R.M. W. and Airdrie, D.E.(1984) Serological variation among Yersinia ruckeri strains. J. Fish Dis., 7, 247–254.

    Article  Google Scholar 

  • Tatner, M.F. and Horne, M.T. (1984) The effect of early exposure of Vibrio anguillarum on the immune response of the fry of the rainbow trout, Salmo gairdneri Richardson. Aquaculture, 41, 193–202.

    Article  Google Scholar 

  • Tilseth, S., Hansen, T. and Møller D. (1991) Historical development of salmon culture. Aquaculture, 98, 1–9.

    Article  Google Scholar 

  • Wu, J.L. (1992) Nucleotide sequences of two cDNA clones of IPNV-Ab type. Bull. Inst. Zool. Academia Sinica, 31(1), 15–22.

    CAS  Google Scholar 

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Aasjord, P.M., Slinde, E. (1994). Fish vaccine: development, production and use of bacterial vaccines, with special reference to salmon. In: Martin, A.M. (eds) Fisheries Processing. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5303-8_17

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  • DOI: https://doi.org/10.1007/978-1-4615-5303-8_17

  • Publisher Name: Springer, Boston, MA

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