Abstract
Numerous animal model systems for investigating breast cancer exist, and new experimental approaches using transgenic and knockout strategies are resulting in the development of models with specific pathogenetic characteristics. Nonetheless, chemically induced mammary carcinogenesis has been investigated for over 50 years, and the results of experiments using this approach continue to provide important insights about the genesis, prevention, and treatment of breast cancer. This chapter provides a detailed account of the methods utilized to implement the two most widely studied chemically initiated models of mammary carcinogenesis in the rat. They are induced by treatment of female rats with either 7,12-dimethylbenz[α]anthracene or 1-methyl-1-nitrosourea.
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Abbreviations
- IBC:
-
Institutional Biohazard Committee
- IACUC:
-
Institutional Animal Care and Use Committee
- DMBA:
-
7,12-dimethylbenz[α]anthracene
- MNU:
-
1-methyl-l-nitrosourea
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© 2000 Springer Science+Business Media New York
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Thompson, H.J. (2000). Methods for the Induction of Mammary Carcinogenesis in the Rat Using either 7,12-Dimethylbenz[α]anthracene or 1-Methyl-1-Nitrosourea. In: Ip, M.M., Asch, B.B. (eds) Methods in Mammary Gland Biology and Breast Cancer Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4295-7_2
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DOI: https://doi.org/10.1007/978-1-4615-4295-7_2
Publisher Name: Springer, Boston, MA
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