Abstract
A number of years ago taurine was recognized as an osmoregulator in marine animals1 and attention has been drawn to its possible participation in cell volume regulation also in terrestial animals.2 It has been suggested that taurine participates in the regulation of extracellular ionic homeostasis in the central nervous system, and in particular, in the active uptake of K+ by astroglial cells.3,4 Recently, some investigators have thought that the role of taurine in the mammalian brain is to act as an osmolyte5,6 which is released as a response to cell swelling.7 Since depolarizing stimuli are known to release taurine from various brain preparations,8,9 this response has been interpreted to ensue from depolarization-induced cell swelling.10
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References
J.W. Simpson, K. Allen, and J. Awapara, Free amino acids in some aquatic invertebrates, Biol. Bull. 117:371 (1959).
E.K. Hoffmann and K.B. Hendil, The role of amino acids and taurine in isosmotic intracellular regulation in Ehrlich ascites mouse tumor cells, J. Comp. Physiol. 108:279 (1976).
W. Walz and E.C. Rinks, Carrier-mediated KC1 accumulation accompanied by water movements is involved in the control of physiological K+ levels by astrocytes, Brain Res. 343:44 (1985).
W. Walz, Swelling and potassium uptake in cultured astrocytes, Can. J. Physiol. Pharmacol. 65:1051 (1987).
N.M. Van Gelder, Brain taurine content as a function of cerebral metabolic rate: osmotic regulation of glucose derived water production, Neurochem. Res. 14:495 (1989).
J.E. Olson and M.D. Goldfinger, Amino acid content of rat cerebral astrocytes adapted to hyperosmotic medium in vitro, Neurosci. Res. 27:241 (1990).
H. Pasantes-Morales, J. Moran, and A. Schousboe, Volume-sensitive release of taurine from cultured astrocytes: properties and mechanism. Glia 3:427 (1990).
S.S. Oja and P. Kontro, Taurine, in:“Handbook of Neurochemistry”, 2nd edn, vol. 3, p. 501, A. Lajtha, ed., Plenum, New York (1983).
P. Saransaari and S.S. Oja, Release of GABA and taurine from brain slices, Prog. Neurobiol., in press (1992).
H. Pasantes-Morales and A. Schousboe, Release of taurine from astrocytes during potassium-evoked swelling, Glia 2:45 (1989).
S.S. Oja and P. Kontro, Cation effects on taurine release from brain slices: comparison to GABA, J. Neurosci. Res. 17:302 (1987).
P. Kontro and S.S. Oja, Taurine and GABA release from mouse cerebral cortex slices: potassium stimulation releases more taurine than GABA from developing brain, Devl Brain Res. 37:277–291 (1987).
M.-L. Laakso and S.S. Oja, Factors influencing the inulin space in cerebral cortex slices from adult and 7-day-old rats, Acta Physiol. Scand. 97:486 (1976).
M.-L. Vahvelainen and S.S. Oja, Kinetics of influx of phenylalanine, tyrosine, tryptophan, histidine and leucine into slices of brain cortex from adult and 7-day-old rats, Brain Res. 40:477 (1972).
I. Holopainen, P. Kontro, and S.S. Oja, Release of taurine from cultured cerebellar granule cells and astrocytes: co-release with glutamate, Neuroscience 29:425 (1989).
H. Pasantes Morales and A. Schousboe, Volume regulation in astrocytes: a role for taurine as an osmoeffector, J. Neurosci. Res. 20:505 (1988).
A. Schousboe, J. Moran, and H. Pasantes-Morales, Potassium-stimulated release of taurine from cultured cerebellar granule neurons is associated with cell swelling. J. Neurosci. Res. 27:71 (1990).
P. Saransaari and S.S. Oja, Excitatory amino acids evoke taurine release from cerebral cortex slices from adult and developing mice, Neuroscience,in press (1991).
S.S. Oja and M.-L. Vahvelainen, Transport of amino acids in brain slices, in: “Research Methods in Neurochemistry”, vol. 3, p. 67, N. Marks and R. Rodnight, eds, Plenum, New York (1975).
P. Kontro, Effects of cations on taurine, hypotaurine, and GABA uptake in mouse brain slices, Neurochem. Res. 7:1391 (1982).
S.S. Oja and P. Kontro, Release of endogenous taurine and y-aminobutyric acid from brain slices from the adult and developing mouse, J. Neurochem. 52:1018 (1989).
P. Kontro and S.S. Oja, S.S. Hypotaurine transport in brain slices: comparison with taurine and GABA, Neurochem. Res. 6:1179 (1981).
E.R. Korpi and S.S. Oja, Comparison of two superfusion systems for study of neurotransmitter release from rat cerebral cortex slices, J. Neurochem. 43:236 (1984).
E.R. Korpi and S.S. Oja, Characteristics of taurine release from cerebral cortex slices induced by sodium-deficient media, Brain Res. 289:197–204 (1983).
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© 1992 Springer Science+Business Media New York
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Oja, S.S., Saransaari, P. (1992). Cell Volume Changes and Taurine Release in Cerebral Cortical Slices. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine. Advances in Experimental Medicine and Biology, vol 315. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3436-5_43
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DOI: https://doi.org/10.1007/978-1-4615-3436-5_43
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