Abstract
Tumors develop an abnormal vascular architecture during growth, resulting in poor perfusion and the occurrence of vessels with intermittent circulation, stasis, and thrombosis1,2. Local areas with hypoxic and anoxic cells, acid pH, and necrotic tissue arise gradually as a consequence of the insufficient blood supply3,4. These abnormal physiological conditions may cause resistance to radio-and chemotherapy, induce gene amplification, and lead to enhanced metastatic potential5,6
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References
R.K. Jain, Determinants of tumor blood flow: A review, Cancer Res. 48:2641 (1988).
P. Vaupel, F. Kallinowski, and P. Okunieff, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review, Cancer Res. 49:6449 (1989).
C.N. Coleman, Hypoxia in tumors: A paradigm for the approach to biochemical and physiologic heterogeneity, J. Nail. Cancer Inst. 80:310 (1988).
I.F. Tannock and D. Rotin, Acid pH in tumors and its potential for therapeutic exploitation, Cancer Res. 49:4373 (1989).
R.M. Sutherland, J.S. Rasey, and R.P. Hill, Tumor biology, Am. J. Clin. Oncol. 11:253 (1988).
R.P. Hill, Tumor progression: Potential role of unstable genomic changes, Cancer Met. Reviews 9:137 (1990).
J.D. Chapman, Measurement of tumor hypoxia by invasive and non-invasive procedures: A review of recent clinical studies, Radiother. Oncol. Suppl. 20:13 (1991).
W. Mueller-Klieser, K.-H. Schlenger, S. Walenta, M. Gross, U. Karbach, M. Hoeckel, and P. Vaupel, Pathophysiological approaches to identifying tumor hypoxia in patients, Radiother. Oncol. Suppl. 20:21 (1991).
P.F. Daly and J.S. Cohen, Magnetic resonance spectroscopy of tumors and potential in vivo clinical applications: A review, Cancer Res. 49:770 (1989).
E.K. Rofstad, NMR spectroscopy in prediction and monitoring of radiation response of tumours in vivo, Int. J. Radial. Biol. 57:1 (1990).
C.T.W. Moonen, P.C.M. van Zip, J.A. Frank, D. Le Bihan, and E.D. Becker, Functional magnetic resonance imaging in medicine and physiology, Science 250:53 (1990).
D.G. Gadian, Magnetic resonance spectroscopy as a probe of tumour metabolism, Eur. J. Cancer 27:526 (1991).
R.G. Steen, Characterization of tumor hypoxia by 31P MR spectroscopy, Am. J. Roentgenol. 157:243 (1991).
R.G. Steen, Edema and tumor perfusion: Characterization by quantitative 1H MR imaging, Am. J. Roentgenol. 158:259 (1992).
E.K. Rofstad, A. Wahl, T. Stokke, and J.M. Nesland, Establishment and characterization of six human melanoma xenograft lines, Acta Pachol. Microbiol. Immunol. Scand. 98:945 (1990).
H. Lyng, A. Skretting, and E.K. Rofstad, Blood flow in six human melanoma xenograft lines with different growth characteristics, Cancer Res. 52:584 (1992).
D. Canet, J. Brondeu, and K. Elbayed, Superfast T 1, determination by inversion-recovery, J. Magn. Resort. 77:483 (1988).
R.H. Thomlinson and L.H. Gray, The histological structure of some human lung cancers and the possible implications for radiotherapy, Br. J. Cancer 9:539, (1955).
R.C. Urtasun, J.D. Chapman, J.A Raleigh, A.J. Franko, and C.J. Koch, Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia, Int. J. Radial. Oncol. Biol. Phys. 12:1263 (1986).
D.G. Hirst, V.K. Hirst, B. Joiner, V. Prise, and K.M. Shaffi, Changes in tumour morphology with alterations in oxygen availability: Further evidence for oxygen as a limiting substrate, Br. J. Cancer 64:54 (1991).
I. Lee, Y. Boucher, and R.K. Jain, Nicotinamide can lower tumor interstitial fluid pressure: Mechanistic and therapeutic implications, Cancer Res. 52:3237 (1992).
R.K. Jain, Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors, Cancer Res. 50:814s (1990).
H.D. Roh, Y. Boucher, S. Kalnicki, R. Buchsbaum, W.D. Bloomer, and R.K. Jain, Interstitial hypertension in carcinoma of uterine cervix in patients: Possible correlation with tumor oxygenation and radiation response, Cancer Res. 51:6695 (1991).
E.K. Rofstad, P. DeMuth, B.M. Fenton, and R.M. Sutherland, 31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia, Cancer Res. 48:5440 (1988).
T.R. Brown, S.D. Buchthal, J. Murphy-Boesch, S.J. Nelson, and J.S. Taylor, A multislice sequence for 31P in vivo spectroscopy. 1D chemical-shift imaging with an adiabatic half-passage pulse, J. Magn. Resort. 82:629 (1989).
R.M. Henkelmann, Diffusion-weighted MR imaging: A useful adjunct to clinical diagnosis or a scientific curiousity?, Am. J. Roentgenol. 155:1066 (1990).
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Rofstad, E.K., Lyng, H., Olsen, D.R., Steinsland, E. (1994). Non-Invasive Assessment of Tumor Oxygenation Status by Integrated 31P NMR Spectroscopy and 1H NMR Imaging. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_71
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DOI: https://doi.org/10.1007/978-1-4615-2468-7_71
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