Abstract
Apoptosis is an important process in the development and homeostasis of multicellular organisms (Jacobson et al 1997). In most cases, apoptosis is executed by activating a proteolytic system involving a family of caspases. Caspases participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in cell death (Cohen 1997). Apoptosis also represents a highly efficient defence mechanism against virus infection; apoptosis aids in removal of viral proteins and nucleic acids by the infected host.
Chapter PDF
Similar content being viewed by others
Keywords
- Mouse Hepatitis Virus
- Proapoptotic Signal
- Transmissible Gastroenteritis Virus
- Unidentified Substance
- Fetal Calf Serum Concentration
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
Belyavskyi, M., Belyavskaya, E., Levy, G. A., and Leibowitz, J. L., 1998, Coronavirus MHV-3-induced apoptosis in macrophages. Virology 250:41–49.
Cohen, G. M., 1997, Caspases: the executioners of apoptosis. Biochem. J. 326:1–16.
Eleouet, J.-F., Chilmonczyk, S., Besnardeau, L., and Laude, H., 1998, Transmissible gastroenteritis Coronavirus induces programmed cell death in infected cells through a caspase-dependent pathway. J. Virol. 72:4918–4924.
Hinshaw, V. S., Olsen, C. W., Dybdahl-Sissoko, N., and Evans, D., 1994, Apoptosis: a mechanism of cell killing by influenza A and B viruses. J. Virol. 68:3667–3673.
Hirano, N., Fujiwara, K., Hino, S., and Matsumoto, M., 1974, Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture. Arch. Fesamte Virusforch. 44:298–302.
Jacobson, M. D., Weil, M., and Raff, M. C., 1997, Programmed cell death in animal development. Cell 88:347–354.
Sturman, L. S., Holmes, K. V., and Behnke, J., 1980, Isolation of Coronavirus envelope glycoproteins and interaction with the viral nucleocapsid. J. Virol 33:449–462.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Chen, CJ., An, S., Makino, S. (2001). Induction of Apoptosis in Murine Coronavirus-Infected 17CI-1 Cells. In: Lavi, E., Weiss, S.R., Hingley, S.T. (eds) The Nidoviruses. Advances in Experimental Medicine and Biology, vol 494. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1325-4_91
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1325-4_91
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5498-7
Online ISBN: 978-1-4615-1325-4
eBook Packages: Springer Book Archive