Abstract
Selenium (Se) was recognized as having nutritional importance fairly late in the development of nutrition knowledge (Schwarz and Foltz, 1957) and, for many years, the nature of its role in nutrition remained clouded by the lack of information about its biochemical mechanisms of action. First, it was regarded only as a factor that could somehow “spare” vitamin E in animal diets; and then it became clear that it was specifically required for the synthesis of a number of proteins, including some with antioxidant like functions (glutathione peroxidases [GPX], thioredoxin reductase), as well as others (iodothyronine 5’-deiodinases [DI]) with important metabolic significance of a different type, all of which contained Se in the form of the unusual amino acid, selenocysteine (SeCys). In fact, information about SeCys-proteins continues to emerge and, with it, understanding of the nutritional and health importance of the trace element continues to expand.
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References
Adler, V., Rincus, M. R., Posner, S., Upadhyay, P., El-Bayoumy., K., and Z. Ronai. Effects of chemopreventive selenium compounds on Jun-N-kinase activities. Carcinogenesis 17:1849–1854, 1996.
An, P. Selenium and endemic cancer in China. In: Environmental bioinorganic chemistry of selenium, edited by P. M. Whanger, G. F. Combs, Jr., and J. Y. Yeh. Beijing: Chin. Acad. Sci. 1995; p. 91–149.
Bertling, C. J., Lin, F., and A. W. Girotti. Role of hydrogen peroxide in the cytosolic effects of UCA/B radiation on mammalian cells. Photochem. Photobiol. 64:137–142, 1996.
Bird, S. M., Uden, P.C., Tyson, J. F., Block, E., and E. Denoyer. Speciation of selenoamino acids and organoselenium compounds in selenium-enriched yeast using high-performace liquid chromatography-inductively coupled plasma mass spectrometry. J. Anal. Atom. Spectrom. 12:785–788, 1997.
Blot, W. J., Li, J. Y., Taylor, P.R., Guo, W., Dawsey, S., Wang, G. Q., Yang. Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease specific mortality among adults with esophagal dysplasia. J. Natl. Cancer Inst. 85: 1492–1498, 1993.
Burke, K. E., Combs, Jr., G.F., Gross, E. G., Bhuyan, K. C., and H. Abu-Libdeh. The effects of topical and oral L-selenomethionine on pigmentation and skin cancer induced by ultraviolet irradiation. Nutr. Cancer 17:123–137, 1992.
Clark, L. C., Combs, G. F., Jr., Turnbull, B. W., Slate, E., Alberts, D., Abele, D., Allison, R., Bradshaw. The nutritional prevention of cancer with selenium 1983–1993: a randomized clinical trial. J. Am. Med. Assoc. 276:1957–1963, 1996.
Clark, L. C., Dalkin, B., Krongrad, A., Combs, G. F., Jr., Turnbull, B. W., Slate, E. H., Witherington, R., Herlong, J. H., Jansko, E., Carpenter, D., Borosso, C., Falk, S., and J. Rounder. Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br. J. Urol. 81:730–734, 1998.
Clark, L. C., Turnbull, B. W., Slate, E. H., Combs, G. F., Frischbach, L. Subgroup analysis of the nutritional prevention of cancer with selenium trial. Carcinoma of the skin: a randomized trial (unpublished research) 1999.
Combs, Jr., G. R. and W. P. Gray. Chemopreventive agents: selenium. Pharmacol. Therapeut. 79:179–192, 1998.
Diamond, A. M., Dale, P., Murray, J. L., and K. J. Grdina. The inhibition of radiation-induced mutagenesis by the combined effects of selenium and the aminothiol WR-1065. Mutat. Res. 356:147–154, 1996.
E1-Bayoumy, K., The effects of organoselenium compounds on induction of mouse forestomach tumors by benzo(a)pyrene. Cancer Res. 45:3631–3635, 1985.
El-Bayoumy, K., The role of selenium in cancer prevention. In: Practice of oncology, 4thedition. Philadelphia: Lippincott 1991;p. 1–15. DeVita, V. T., Hellman, S., and S. S. Rosenberg (eds.).
Emonet, N., Leccia, M. R. Favier, A., Beani, J. C., and M. J. Richard. Thiols and selenium: protective effect of human skin fibroblasts exposed to UVA radiation. J. Photochem. Photobiol. B. 40:84–90, 1997.
Gray, W. P., Hyun, T., and G. F. Combs, Jr. Low molecular weight selenium in chick plasma. FASEB J. (in press), 1999.
Ip, C. Differential effect of dietary methionine on the biopotency of selenomethionine and selenite in cancer chemoprevention. J. Natl. Cancer Inst. 80:258–262, 1988.
Ip, C. Lessons from basic research in selenium and cancer prevention. J. Nutr. 128:1845–1854, 1998.
Ip, C., El-Bayoumy, K., Upadhyaya, P., Ganther, H., Vandanavikit, S., and H. Thompson. Comparative effect on inorganic and organic selenocyanate derivatives in mammary cancer prevention. Carcinogen. 15:187–192, 1994.
Ip, C., and H. Ganther. Activity of methylated forms of selenium in cancer prevention. Cancer Res. 50:1206–1211, 1990.
Ip, C. and H. Ganther. Combination of blocking agents and suppressing agents in cancer prevention. Carcinogenesis 12:365, 1991.
Ip, C. and H. E. Ganther. Comparison of selenium and sulfur analogs in cancer prevention. Carcinogenesis 13:1167–1170, 1992a.
Ip, C. and H. E. Ganther. Biological activities of trimethylselenonium as influenced by arsenite. J. Inorgan. Biochem. 46:215–222, 1992.
Ip, C. and H. Ganther. Novel strategies in selenium cancer chemoprevention research. In: Selenium in biology and human health, edited by R. F. Burk. New York: Springer-Verlag 1993;p. 170–170.
Kise, Y., Yamamura, M., Kogata, M., Nakagawa, M., Uetsuji, S., Takada, H., Hioki, K., and M. Yamamoto. Inhibition by selenium of intrahepatic cholangiocarcioma induction in Syrian golden hamsters by N-nitrosobis(2-oxopropyl)amine. Nutr. Cancer 16: 153–164, 1991.
Kramer, K., Looks, M. P. Chrissafidou, A., Karsten, S., and J. Areads. Selen and tumarerkrankugen. Akt. Ernahr.-Med. 21:103–113. 1996.
Leccia, M. T., Richard, M. J., Beani, J. C., Faure, H., Monjo, A. M., Cadet, J., Amblard, P., and A. Favier. Protective effect of selenium and zinc on UV - A damage in human skin fibroblasts. Photochem. Photobiol. 58:548–553, 1993.
Li, J. Y., Taylor, P.R., Li, B., Blot, Wl J., Guo, W., Dawset, S., Wang, G. Q., Yang, C. S., Zheng, S. F., Gail, M., Li, G. Y., Liu, B. Q., Tangrea, I., Sun, Y. H., Liu, F., Fraumeni, F., Jr., and Y. H., Zhang. Nutrition intervention trials in Linxian, China. J. Nat. Cancer Inst. 85:1492–1498, 1993.
Lu, J., Jiang, C., Kaeck, M., Ganther, H. Ip, C., and H. Thompson. Cellular and metabolic effects of triphenyselenoium chloride in a mammary cell culturer model.Carcinogenesis. 16:513–516, 1995.
Moysan, A.Jr, Morliere, P., MarquisI. Richard, A., and L. Dubertret. Effects of selenium on UCA-induced lipid peroxidation in cultured human skin fibroblasts. Skin Pharmacol. 8:139–148, 1995.
Nayini, J., El-Bayoumy, K., Sugie, S., Cohen, L. A., and B. S. Reddy. Chemoprevention of experimental mammary carcinogenesis by the synthetic organoselenium compound, benzylselnocyanate, in rats. Carcinogenesis. 10:509–512, 1989.
Pence, B. C., Pelier, E., and D. M. Dunn. Effects of dietary selenium UCB-induced skin carcinogenesis and epidermal antioxidant status. J. Invest. Dermatol. 102:759–761, 1994.
Perchellet, J. P., Abney, N.L. Thomas, R. M., Guislan, Y. L., and E. M., Perchellet. Effects of combined treatments with selenium, glutathione and vitamin E on glutathione peroxidase activity, ornithine decarboxylase induction and complete and multistage carcinogenesis in mouse skin. Cancer Res. 47:477–485, 1987.
Poirier, K. A., and J. A. Milner, Factors influencing the antitumorigenic properties of selenium in mice. J. Nutr. 113:2147–2154, 1983.
Prokopczyk, B., CoxJ. E., UpadhyayaP. Amin, S., DesaiD. HoffmannD. and K. El-Bayoumy. Effects of dietary 1, 4-phenylenebis(methylene)selenocyanate on 4(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation in lung and liver of A/J mice and F344 rats. Carcinogenesis 17: 749–753, 1996.
Reddy, B. S., Sugie, S.MaruyamaH. El-Bayoumy, K.and P. Marra. Chemoprevention of colon carcinogenesis by dietary organselenium, benzylselenocyanate, in F344 rats. Cancer Res. 47:5901–5904, 1987.
Ronai, Z., Tillotson, J. K., Traganos, F., Darzynkiewice, Z., Conaway, C. C., Upadhyaya, P., and K. El-Bayoumy. Effects of organic and inorganic selenium compounds on rat mammary tumor cells. Int. J. Cancer 63:428–434, 1995.
Schwarz, K. C. M. Foltz. Selenium as an integral part of factor 3 agains dietary necrotic liver degeneration. J. Am. Chem. Soc. 79:3292–3293, 1957.
Shamberger, R.J. and D. V. Frost. Possible protective effect of selenium against human cancer. Can. Med. Assoc. J. 100:682–686, 1969.
Yang, G. Q., Yin, S., and R. Zhou. Studies of safe maximal daily dietary Se-intake in a seleniferous area in China. 1. Selenium intake and tissue selenium levels of the inhabitants. J. Trace Elem. Electrolytes Heatlh Dis. 3:77–86, 1989.
Yu, S. Y., Zhu, Y. J., and W. G. Li. Protective role of selenium against hepatitis B virus and primany level cancer in Qidong. Biol. Trace. Elem. Res. 56:117–124, 1997.
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Combs, G.F. (2001). Considering the Mechanisms of Cancer Prevention by Selenium. In: Nutrition and Cancer Prevention. Advances in Experimental Medicine and Biology, vol 492. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1283-7_9
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DOI: https://doi.org/10.1007/978-1-4615-1283-7_9
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