Abstract
Dry eye syndrome (DES) represents a heterogeneous group of conditions that share inadequate lubrication of the ocular surface as their common denominator. DES is characterized by symptoms of ocular dryness and discomfort due to insufficient tear quantity or quality caused by low tear production and/or excessive tear evaporation. Symptoms can be debilitating 1 and, when severe, may affect psychological health and ability to work. No cure exists for DES, which is one of the leading causes of patient visits to ophthalmologists and optometrists in the United States. Because of the presumed high prevalence of DES and the attendant health care burden, the National Eye Institute (NEI) has identified tear film and dry eye research as important areas in need of further study.
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References
McMonnies, C.W. and H. Ho, Patient history in screening for dry eye conditions. J Am Optom Assoc,58: p. 296–301 (1987).
Lemp, M.A., Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. Clao J, 21(4): p. 221–32 (1995).
Schein, O.D.et al.Prevalence of dry eye among the elderly. Am J Ophthalmol, 124(6): p. 723–8 (1997).
Moss, S.E., R. Klein, and B.E. Klein, Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol, 118(9): p. 1264–8 (2000).
McCarty, C.A.et al.The epidemiology of dry eye in Melbourne, Australia. Ophthalmology, 105(6): p. 1114–9 (1998).
Schaumberg, D.A.et al.The epidemiology of dry eye syndrome. Cornea, 19 (Suppl): p. S120 (2000).
Schein, O.D.et al.Relation between signs and symptoms of dry eye in the elderly. A population-based perspective. Ophthalmology, 104(9): p. 1395–401 (1997).
Schaumberg, D.A.et al.Hormone replacement therapy and the prevalence of dry eye symptoms in women. Invest Ophthalmol Vis Sci, 41: p. S740 (2000).
Nichols, K.K., J.J. Nichols, and K. Zadnik, Frequency of dry eye diagnostic test procedures used in various modes of ophthalmic practice. Cornea, 19(4): p. 477–82 (2000).
Korb, D.R., Survey of preferred tests for diagnosis of the tear film and dry eye. Cornea, 19(4): p. 483–6 (2000).
Rexrode, K.M.et al.Baseline characteristic of participants in the Women’s Health Study. J Women’s Health & Gender—Based Med, 9(1): p. 19–27 (2000).
Steering Committee of the Physicians’ Health Study Research Group. Final report on the aspirin component of the ongoing Physicians’ Health Study [see comments]. N Engl J Med, 321(3): p. 129–35 (1989).
Oden, N.L.et al.Sensitivity and specificity of a screening questionnaire for dry eye. Adv Exp Med Biol, 438: p. 807–20 (1998).
Mathers, W.D., J.A. Lane, and M.B. Zimmerman, Tear film changes associated with normal aging. Cornea, 15(3): p. 229–34 (1996).
Henderson, J.W. and W.A. Prough, Influence of age and sex on flow of tears. Arch Ophthalmol, 43: p. 224–31 (1950).
Sullivan, D.A.et al.Influence of gender, sex steroid hormones, and the hypothalamic-pituitary axis on the structure and function of the lacrimal gland. Adv Exp Med Biol, 438: p. 11–42 (1998).
Sullivan, D.A., Sex hormones and Sjogren s syndrome.JRheumatol, 24 Suppl 50: p. 17–32 (1997).
Homo-Delarche, F.et al.Sex steroids, glucocorticoids, stress and autoimmunity. J Steroid Biochem Mol Biol, 40(4–6): p. 619–37 (1991).
Ahmed, S.A.et al., Estrogen induces the development of autoantibodies and promotes salivary gland lymphoid infiltrates in normal mice. JAutoimmun, 2(4): p. 543–52 (1989).
Sato, E.H. and D.A. Sullivan, Comparative influence of steroid hormones and immunosuppressive agents on autoimmune expression in lacrimal glands of a female mouse model of Sjogren s syndrome. Invest Ophthalmol Vis Sci, 35(5): p. 2632–42 (1994).
Sullivan, D.A.et al.Androgens and dry eye in Sjogren’s syndrome. Ann N Y Acad Sci, 876: p. 312–24 (1999).
Cutolo, M.et al.Estrogens, the immune response and autoimmunity. Clin Exp Rheumatol, 13(2): p. 217–26 (1995).
Lahita, R.G., The connective tissue diseases and the overall influence of gender. Int J Fertil Menopausal Stud, 41(2): p. 156–65 (1996).
Imperato-McGinley, J.et al.The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity. J Clin Endocrinol Metab, 76(2): p. 524–8 (1993).
Sullivan, D.A.et al.Androgen regulation of the meibomian gland. Adv Exp Med Biol, 438: p. 327–31 (1998).
Bologna, J.L., Aging skin. Am J Med Suppl, IA: p. 99S–102S (1995).
Zeligs, M.A. and K. Gordon, Dehydroepiandrosterone therapy for the treatment of dry eye disorders, in Int Patent Application. 1994.
Doughty, M.J.et al.A patient questionnaire approach to estimating the prevalence of dry eye symptoms in patients presenting to optometric practices across Canada. Optom Vis Sci, 74(8): p. 624–31 (1997).
Schaumberg, D.A., D.A. Sullivan, and M.R. Dana, The relationship of hormone replacement therapy with the prevalence of dry eye syndrome in a large cohort of women. Ophthalmology, 107 (Suppl.): p. 105 (2000).
Belchetz, P.E., Hormonal treatment of postmenopausal women. N Engl J Med, 330(15): p. 1062–71 (1994).
Thody, A.J. and S. Shuster, Control and function of sebaceous glands. Physiol Rev, 69(2): p. 383–416 (1989).
Gurwood, A.S.et al.Idiosyncratic ocular symptoms associated with the estradiol transdermal estrogen replacement patch system. Optom Vis Sci, 72(1): p. 29–33 (1995).
Brennan, N.A. and N. Efron, Symptomatology of HEMA contact lens wear. Optom Vis Sci, 66(12): p. 834–8 (1989).
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© 2002 Kluwer Academic/Plenum Publishers
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Schaumberg, D.A., Sullivan, D.A., Dana, M.R. (2002). Epidemiology of Dry Eye Syndrome. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_140
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_140
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