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Role of Immunity and Inflammation in Corneal and Ocular Surface Disease Associated with Dry Eye

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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 506))

Abstract

Dry eye syndromes (DES) represent a common but highly heterogeneous group of ocular surface disorders (OSD) that affect millions of individuals, in particular women, in the United States alone. While efforts to better classify disease categories and determine relevant diagnostic tests for each disea sesubtype continue, common features of DES are shared by the tear-deficient and non-tear-deficient (evaporative) forms of DES serving as common denominators of disease. These common denominators include ocular surface epitheliopathy, tear hyperosmolarity, an unstable preocular tear film and symptoms of dry eye associated with varying degrees of inflammation.’ As such, an increasing number of investigators contend ocular irritation or discomfort, virtually invariable components of severe tear-deficient dry eye, are clinical correlates of ocular surface inflammation which at the cellular and molecular levels are requisite factors for the pathogenesis of DES. In this brief overview, we will first examine the factors involved in the generation of immune responsiveness to antigens in the ocular surface and anterior segment. We will then critically evaluate whether the data generated to date provide a causal link between the generation of adaptive immunity and OSD in DES, or if the well-described inflammatory response in the ocular surface could be primarily a consequence of the myriad pathological

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Author information

Authors and Affiliations

  1. Laboratory of Immunology Schepens Eye Research Institute and the Department of Ophthalmology Harvard Medical School, USA

    M. Reza Dana & Pedram Hamrah

  2. Brigham and Women’s Hospital, USA

    M. Reza Dana

  3. Massachusetts Eye and Ear Infirmary Boston, Massachusetts, USA

    M. Reza Dana

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  1. M. Reza Dana
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  2. Pedram Hamrah
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    David A. Sullivan , Darlene A. Dartt  & Rose M. Sullivan ,  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  3. Allergan, Inc., Irvine, California, USA

    Michael E. Stern

  4. Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  5. Ichikawa General Hospital, Chiba, Japan

    Kazuo Tsubota

  6. University of New Orleans, New Orleans, Louisiana, USA

    B. Britt Bromberg

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© 2002 Kluwer Academic/Plenum Publishers

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Dana, M.R., Hamrah, P. (2002). Role of Immunity and Inflammation in Corneal and Ocular Surface Disease Associated with Dry Eye. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_103

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_103

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

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