Abstract
The acquired immunodeficiency syndrome (AIDS) is an often fatal illness characterized by a profound derangement in cell-mediated immunity (CMI), leading to multiple opportunistic infections and unusual neoplasms (10, 18, 23, 28). Epidemiologic evidence indicates that this syndrome, which was first reported in the spring of 1981 (8, 9), is transmissible sexually and by parenteral exposure to blood or blood products. Recent virologic and serologic studies suggest a causal link between AIDS and infection with an as yet unclassified retrovirus (3, 12, 21) related to the human T-lymphotropic retroviruses (20). Impaired CMI in AIDS patients is thought to be caused by infection of and reduction in the number of T-helper lymphocytes by this virus, which was first isolated from a lymph node of a homosexual man with unexplained lymphadenopathy and was tentatively called lymphadenopathy-associated virus (3).
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References
Aronson IK, Soltani K: Chronic mucocutaneous candidosis: a review. Mycopathologia 60: 17–25, 1976.
Arroyo JC, Nichols S, Carroll GF: Disseminated Nocardia caviae infection. Am J Med 62: 409–412, 1978.
Barre-Sinoussi F, Chermann JC, Rey F, Nygeyre MT, Chamaret S, Gruest J, Dauget C, Apler-Blin C, Vezinet-Brun F, Rozinx C, Rozenbaum W, Montag-nier L: Isolation of a T-lymphotropic retrovirus from a patient at risk for AIDS. Science 220: 870–871, 1983.
Beaman L, Pappagianis D, Benjami E: Significance of T cells in resistance to experimental murine coccidioidomycosis. Infect Immun 17: 580–585, 1977.
Bodey GP: Fungal infections complicating acute leukemia. J Chronic Dis 19: 667–687, 1966.
Carbone PP, Sabesin SM, Sideranski H, Frei H: Secondary aspergillosis. Ann Intern Med 60: 556–567, 1964.
Causey WA, Lee R: Nocardiosis, in Vinken PJ, Bruyn GW (eds): Handbook of Clinical Neurology. Amsterdam, North Holland Publishing Co, 1978, pp 517–530.
Centers for Disease Control: Pneumocystis pneumonia—Los Angeles. Morbidity Mortality Weekly Rep 30: 250–252, 1981.
Centers for Disease Control: Kaposi’s sarcoma and Pneumocystic pneumonia among homosexual men—New York City and California. Morbidity Mortality Weekly Rep 30: 305–308, 1981.
Centers for Disease Control Task Force on Kaposi’s Sarcoma and Opportunistic Infections: Epidemiologic aspects of the current outbreak of Kaposi’s sarcoma and opportunistic infections. N Engl J Med 306: 248–252, 1982.
Centers for Disease Control: Update: Acquired immunodeficiency syndrome (AIDS)—United States. Morbidity Mortality Weekly Rep 33: 337–339, 1984.
Centers for Disease Control: Antibodies to a retrovirus etiologically associated with acquired immunodeficiency syndrome (AIDS) in populations with increased incidences of the syndrome. Morbidity Mortality Weekly Rep 33: 377–379, 1984.
Chandler FW, Kaplan W, Ajello L: Color Atlas and Text of the Histopathology of Mycotic Diseases. Chicago, Yearbook Medical Publishers, 1980.
Cho SY, Choi HY: Opportunistic fungal infection among cancer patients. Am J Clin Pathol 72: 617–621, 1979.
Cohen MS, Isturiz RE, Malech HL, Root RK, Wilfert CM, Gutman L, Buckley RH: Fungal infection in chronic granulomatous disease. Am J Med 71: 59–66, 1981.
Diamond RD, Allison AC: Nature of the effector cells responsible for antibody-dependent cell-mediated killing of Cryptococcus neoformans. Infect Immun 14: 716–720, 1976.
Diamond RD, Krzesicki R, Epstein B, Jao W: Damage to hyphal forms of fungi by human leukocytes in vitro—a possible host defense mechanism in aspergillosis and mucormycosis. Am J Pathol 91: 313–328, 1978.
Durack DT: Opportunistic infections and Kaposi’s sarcoma in homosexual men. N Engl J Med 305: 1465–1467, 1981.
Eras P, Goldstein MJ, Sherlock P: Candida infection of the gastrointestinal tract. Medicine (Baltimore) 51: 367–379, 1972.
Gallo RC, Sarin PS, Gelmann EP, Robert-Guroff M, Richardson E, Kalyanaraman VS, Leibowitch J, Popovic M: Isolation of human T-cell leukemia virus in AIDS. Science 220: 865–867, 1983.
Gallo RC, Salahuddin SZ, Popovic M, Shearer GM, Kaplan M, Haynes BF, Palker RJ, Redfield R, Oleske J, Safai B, White G, Foster P, Markham PD: Frequent detection and isolation of cytopathic retrovirus (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224: 500–503, 1984.
Goodwin RA Jr, Des Prez RM: Histoplasmosis. Am Rev Respir Dis 117: 929–956, 1978.
Gottlieb MS, Schjroff R, Schanker HM, Weisman JD, Fan PT, Wolf RA, Saxon A: Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: Evidence of a new acquired cellular immunodeficiency. N Engl J Med 305: 1425–1431, 1981.
Grieco MH: Humoral and cellular responses to infection, in Grieco MH (ed): Infections in the Abnormal Host. New York, Yorke Medical Books, 1980, pp 131–304.
Grimley PM, Wright LD, Jennings AE: Torulopsis glabrata infection in man. Am J Clin Pathol 43: 216–223, 1965.
Guarda LA, Luna MA, Smith JL Jr, Mansell PWA, Gyorkey F, Roca AN: Acquired immune deficiency syndrome: Postmortem findings. Am J Clin Pathol 81: 549–557, 1984.
Gustafson TL, Schaffner W, Lavely GB, Stratton CW, Johnson HK, Hutcheson RH Jr: Invasive aspergillosis in renal transplant recipients: correlation with corticosteroid therapy. J Infect Dis 148: 230–238, 1983.
Jaffe HW, Bregman DJ, Selik RM: Acquired immune deficiency syndrome in the United States: the first 1,000 cases. J Infect Dis 148: 339–345, 1983.
Kaplan W: Practical application of fluorescent antibody procedures in medical mycology, in Mycoses. Washington, DC, Scientific Publication No 304, Pan American Health Organization, 1975, pp 178–185.
Kaplan W, Kraft DE: Demonstration of pathogenic fungi in formalin-fixed tissues by immunofluorescence. Am J Clin Pathol 52: 430–437, 1969.
Katzenstein ALA, Maksen J: Candidal infection of gastric ulcers. Am J Clin Pathol 71: 137–141, 1979.
Kirkpatrick CH, Smith TK: Chronic mucocutaneous candidiasis: immunologic and antibiotic therapy. Ann Intern Med 80: 310–320, 1974.
Krick JA, Remington JS: Opportunistic invasive fungal infections in patients with leukemia and lymphoma. Clin Haematol 5: 249–310, 1976.
Masur H, Rosen PP, Armstrong D: Pulmonary disease caused by Candida sp. Am J Med 63: 914–925, 1977.
Myerowitz RL, Pazin GJ, Allen CM: Disseminated candidiasis: changed in incidence, underlying diseases, and pathology. Am J Clin Pathol 68: 29–38, 1977.
Nash G: Pathologic features of the lung in the immunocompromised host. Hum Pathol 13: 841–858, 1982.
Nash G, Fligiel S: Pathologic features of the lung in the acquired immune deficiency syndrome (AIDS): An autopsy study of seventeen homosexual males. Am J Clin Pathol 81: 6–12, 1984.
Opelz G, Scheer MT: Cutaneous sensitivity and in vitro responsiveness of lymphocytes in patients with disseminated coccidioidomycosis. J Infect Dis 132: 250–255, 1975.
Parker JC, McCloskey JJ, Knauer KA: Pathobiologic features of human candidiasis: A common deep mycosis of the brain, heart, and kidney in the altered host. Am J Clin Pathol 65: 991–1000, 1976.
Reichert CM, O’Leary TJ, Levens DL, Simrell CR, Macher AM: Autopsy pathology in the acquired immune deficiency syndrome. Am J Pathol 112: 357–382, 1983.
Rodrigues RJ, Shinya H, Wolff WT, Puttlitz D: Torulopsis glabrata funge-mia during prolonged intravenous alimentation therapy. N Engl J Med 284: 540–541, 1971.
Rosen PP: Opportunistic fungal infections in patients with neoplastic diseases. Pathol Ann 11: 255–315, 1976.
Schaffner A, Douglas H, Braude A: Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. J Clin Invest 69: 617–631, 1982.
Schaffner A: Acquired immune deficiency syndrome—Is disseminated aspergillosis at least moderately predictive of underlying cellular immune deficiency? J Infect Dis 149: 828–829, 1984.
Small CB, Klein RS, Friedland GH, Moll B, Emeson EE, Spigland I: Community-acquired opportunistic infections and defective cellular immunity in heterosexual drug abusers and homosexual men. Am J Med 74: 433–441, 1983.
Wheat LJ, Small CB: Disseminated histoplasmosis in the acquired immunodeficiency syndrome. Arch Intern Med 144: 2147–2149, 1984.
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Chandler, F.W. (1985). Pathology of the Mycoses in Patients with the Acquired Immunodeficiency Syndrome (AIDS). In: McGinnis, M.R. (eds) Current Topics in Medical Mycology. Current Topics in Medical Mycology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9547-8_1
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