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Clozapine: Mechanism of Action in Relation to its Clinical Advantages

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Recent Advances in Schizophrenia

Abstract

Clozapine, a dibenzodiazepine, is the prototype of an atypical antipsychotic drug. A generally accepted definition of an atypical antipsychotic drug is one that produces weak catalepsy in rodents, minimal extrapyramidal side effects (EPS) at clinically effective doses, and minimal plasma prolactin (PRL) elevations in humans.1 Almost all such agents are dopamine (DA) receptor antagonists, and block stereotypy or locomotor activity in rodents due to stimulation of DA receptors by direct-acting DA agonists, (eg, apomorphine) or indirect DA agonists (eg, d-amphetamine). Atypical antipsychotic drugs block the conditioned avoidance response, another test which indicates their antipsychotic potential. Clozapine clearly fits this definition.1–3

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  1. Herbert Y. Meltzer
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© 1990 Springer-Verlag New York Inc.

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Meltzer, H.Y. (1990). Clozapine: Mechanism of Action in Relation to its Clinical Advantages. In: Recent Advances in Schizophrenia. International Perspectives Series: Psychiatry, Psychology, and Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3248-3_11

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  • DOI: https://doi.org/10.1007/978-1-4612-3248-3_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-97221-3

  • Online ISBN: 978-1-4612-3248-3

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