Abstract
This chapter includes information based on published literature on utilization of agro industrial residues for the production of bioactive compounds. Various approaches using microbial fermentation technology have been explored for the production of bioactive compounds which as secondary metabolites could be produced by selected microorganisms. Certain factors have been found to affect the productivity of these compounds, hence the yield of secondary metabolites may be manipulated by controlling these factors in fermentation system.
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
Keywords
References
Balakrishnan K, Pandey A (1996) Production of biologically active secondary metabolites in solid state fermentation. J Sci Ind Res 55: 365–372
Chang SB, Abdel-Kadar M.M, Wick EL, Wogan GN (1963) Aflatoxin B2: chemical identity and biological activity. Science 142: 1191–1192
Collemare J, Billard A, Bohnert HU, Lebrun MH (2008) Biosynthesis of secondary metabolites in the rice blast fungus Magnaporthe grisea: the role of hybrid PKS-NRPS in pathogenicity. Mycol Res Feb 112(Pt 2): 207–215
Datar R (1986) Economics of primary separation steps in relation to fermentation and genetic engineering. Process Biochem 21: 19–26
Demain AL, Hunt AN, Malik V, Kobbe B, Hawkins H, Matsuo K, Wogan GN (1977) Improved procedure for production of cytochalasin E and tremorgenic toxins by Aspergillus clavatus. Appl Environ. Microbiol 31: 138–140
Ghose AC, Manmade A, Townsend JM, Bosquet A, Howes JF, Demain AL (1978) Production of cyclochlorotine and a new metabolite, simatoxin by Penicillium islandicum. Appl Environ Microbiol 35: 1074–1078
Greenhalgh R, Neish GA, Miller D (1983) Deoxynivalenol, acetyl deoxynivalenol, and zearalenone formation by Canadian isolates of Fusarium graminarium on solid substrates. Appl Environ Microbiol 46: 625–629
Hesseltine CW (1977) Solid state fermentation-Part I. Process Biochem 12(6): 24–27
Jermini MFG, Demain AL (1989) Solid state fermentation for cephalosporin production by Streptomyces clauvligerus and Cephalosporin acremonium. Experienta 45: 1061–1065
Khaldi N, Collemare J, Lebrun MH, Wolfe KH (2008, Jan 24) Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi. Genome Biol 9(1): R18
Kobbe B, Cushman M, Wogan GN, Demain AL (1977) Production and antibacterial activity of malformin C, a toxic metabolite of Aspergillus niger. Appl Environ Microbiol 33: 996–997
Kumar PKR, Lonsane BK (1987a) Gibberellic acid by SSF: consistent and improved yields. Biotechnol Bioeng 30: 267–271
Kumar PKR, Lonsane BK (1987b) Extraction of gibberellic acid from dry mouldy bran produced under solid-state fermentation. Process Biochem 22: 139–143
Kumar PKR, Lonsane BK (1987c) Potential of fed-batch culture in solid-state fermentation for the production of gibberellic acid. Biotechnol Lett 9: 179–182
Kumar PKR, Lonsane BK (1988) Batch and fed-batch solid-state fermentations: kinetics of cell growth, hydrolytic enzymes production, and gibberellic acid production. Process Biochem 23(2): 43–47
Lin CF, Lizuka H (1982) Production of pigment by a mutant of Monascus kaoliang sp. nov. Appl Environ Microbiol 43: 671–676
Lindenfelser LA, Ciegler A (1975) Solid state fermenter for ochratoxin A production. Appl Microbiol 29: 323–327
Luk KC, Kobbe B, Townsend JM (1977) Production of cyclopiazonic acid by Aspergillus flavus. Appl Environ Microbiol 33: 211–212
Nigam P, Singh D (2000) Secondary Metabolites. In Encyclopedea of Food Microbiology (RK Robinson et al. eds.) Academic Publisher, London
Nigam P, Singh D (1999) Characteristics and techniques of fermentation systems in Biotechnology: Food Fermentation, Vol. II, (VK Joshi, A Pandey eds) Educational Publishers, N Delhi, pp. 427–466
Nigam P, Singh D (1996a) Processing of agricultural wastes in solid state fermentation for microbial protein production. J Sci Ind Res 55: 373–380
Nigam P, Singh D (1996b) Processing of agricultural wastes in solid state fermentation for cellulolytic enzyme production. J Sci Ind Res 55: 457–467
Nigam P, Singh D (1994) Solid-state (substrate) fermentation systems and their applications in biotechnology. J Basic Microbiol 34: 405–423
Pandey A, Soccol CR, Nigam P, Soccol VT, Vandenberghe LPS, Mohan R (2000a) Biotechnological potential of agro-industrial residues: II cassava bagasse. Bioresource Technol 74(1): 81–87
Pandey A, Soccol CR, Nigam P, Soccol VT (2000b) Biotechnological potential of agro-industrial residues: I sugarcane bagasse. Bioresource Technol 74(1): 69–80
Pandey A, Soccol CR, Rodriguez-Leon JA and Nigam P (2001) Production of organic acids by solid state fermentation. In Solid state fermentation in Biotechnology-Fundamentals and Applications, Asitech Publishers N. Delhi, pp. 132–158
Patron NJ, Walker RF, Cozijnsen Aj et al. (2007) Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes. BMS Evol Biol Sep 26(7): 174–179
Robinson T, Nigam P, Singh D (2004) Secondary metabolites. In Handbook of Fungal Biotechnology, (DK Arora et al. eds.) Marcel Dekker Inc, NY pp. 267–274 ISBN 08247-4018-1
Robinson T, Singh D, Nigam P (2001) Solid-state fermentation: A promising microbial technology for secondary metabolite production. Appl Microbio Biotechnol 55: 284–289
Shotwell OL, Hesseltine CW, Stubblefield RD, Sorenson WG (1966) Appl Microbiol 14: 425–428
Silman RW, Conway HF, Anderson RA, Bagley EB (1979) Production of aflatoxin in corn by a large-scale solid-substrate fermentation process. Biotechno Bioeng 21: 1799–1808
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer Science+Business Media B.V.
About this chapter
Cite this chapter
Singh nee’ Nigam, P. (2009). Production of Bioactive Secondary Metabolites. In: Singh nee’ Nigam, P., Pandey, A. (eds) Biotechnology for Agro-Industrial Residues Utilisation. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9942-7_7
Download citation
DOI: https://doi.org/10.1007/978-1-4020-9942-7_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-9941-0
Online ISBN: 978-1-4020-9942-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)