Malignant tumors of the skeleton represent a diverse group of primary and secondary neoplasms, each with unique imaging and clinical features. The radiologist encountering a lesion of the skeleton must apply a methodical approach to the analysis of imaging features to distinguish benign from malignant entities. This methodical approach can provide invaluable insight into the nature of the lesion, and will ultimately guide the final diagnosis; indeed, concordance between the imaging appearance and a preliminary histologic diagnosis is absolutely necessary to ensure that each lesion is appropriately diagnosed and managed. For the clinician, there is an ever-expanding array of potential imaging modalities that can characterize a lesion and evaluate its extent. Imaging will guide treatment, monitor response to therapy and facilitate discussions of prognosis. The purpose of this chapter is to familiarize the practicing clinician and radiologist with the most common malignant lesions of the skeleton. The chapter describes the major primary lesions of bone (osteosarcoma, chondrosarcoma, myeloma, Ewing’s Sarcoma and primary lymphoma of bone), as well as metastasis. Our goal is to familiarize the reader with the key imaging characteristics of each lesion, as well as the clinical features that may guide the differential diagnosis. The discussion incorporates all imaging modalities, including radiographs, magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET) and bone scintigraphy, with a particular focus on the appropriate use of each modality in the diagnosis and staging of a newly detected lesion. Recent evidence, particularly focused on the newer modalities (MRI and PET), is presented to provide an evidence-based foundation for the imaging work-up.
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Keywords
- Positron Emission Tomography
- Multiple Myeloma
- Standardize Uptake Value
- Bone Scintigraphy
- Soft Tissue Mass
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References
Lodwick G S, Wilson A J, Farrell C, Virtama P, and Dittrich F. Determining growth rates of focal lesions of bone from radiographs. Radiology, 134: 577–583, 1980.
Lodwick G S, Wilson A J, Farrell C, Virtama P, Smeltzer F M, and Dittrich F. Estimating rate of growth in bone lesions: observer performance and error. Radiology, 134: 585–590, 1980.
Arndt C A and Crist W M. Common musculoskeletal tumors of childhood and adolescence. N Engl J Med, 341: 342–352, 1999.
Murphey M D, Robbin M R, McRae G A, Flemming D J, Temple H T, and Kransdorf M J. The many faces of osteosarcoma. Radiographics, 17: 1205–1231, 1997.
Miller S L and Hoffer F A. Malignant and benign bone tumors. Radiol Clin North Am, 39: 673–699, 2001.
Sajadi K R, Heck R K, Neel M D, et al. The incidence and prognosis of osteosarcoma skip metastases. Clin Orthop Relat Res: 92–96, 2004.
Brenner W, Bohuslavizki K H, and Eary J F. PET imaging of osteosarcoma. J Nucl Med, 44: 930–942, 2003.
Huvos A G, Rosen G, Bretsky S S, and Butler A. Telangiectatic osteogenic sarcoma: a clinicopathologic study of 124 patients. Cancer, 49: 1679–1689, 1982.
Murphey M D, wan Jaovisidha S, Temple H T, Gannon F H, Jelinek J S, and Malawer M M. Telangiectatic osteosarcoma: radiologic-pathologic comparison. Radiology, 229: 545–553, 2003.
Klein M J and Siegal G P. Osteosarcoma: anatomic and histologic variants. Am J Clin Pathol, 125: 555–581, 2006.
Nakajima H, Sim F H, Bond J R, and Unni K K. Small cell osteosarcoma of bone. Review of 72 cases. Cancer, 79: 2095–2106, 1997.
Jaffe H L. Intracortical osteogenic sarcoma. Bull Hosp Joint Dis, 21: 189–197, 1960.
Smith J, Botet J F, and Yeh S D. Bone sarcomas in Paget disease: a study of 85 patients. Radiology, 152: 583–590, 1984.
McCarville M B, Christie R, Daw N C, Spunt S L, and Kaste S C. PET/CT in the evaluation of childhood sarcomas. AJR Am J Roentgenol, 184: 1293–1304, 2005.
Rodriguez-Galindo C, Shah N, McCarville M B, et al. Outcome after local recurrence of osteosarcoma: the St. Jude Children’s Research Hospital experience (1970–2000). Cancer, 100: 1928–1935, 2004.
Wittig J C, Bickels J, Priebat D, et al. Osteosarcoma: a multidisciplinary approach to diagnosis and treatment. Am Fam Physician, 65: 1123–1132, 2002.
Imbriaco M, Yeh S D, Yeung H, et al. Thallium-201 scintigraphy for the evaluation of tumor response to preoperative chemotherapy in patients with osteosarcoma. Cancer, 80: 1507–1512, 1997.
Menendez L R, Fideler B M, and Mirra J. Thallium-201 scanning for the evaluation of osteosarcoma and soft tissue sarcoma. A study of the evaluation and predictability of the histological response to chemotherapy. J Bone Joint Surg Am, 75: 526–531, 1993.
Bredella M A, Caputo G R, and Steinbach L S. Value of FDG positron emission tomography in conjunction with MR imaging for evaluating therapy response in patients with musculoskeletal sarcomas. AJR Am J Roentgenol, 179: 1145–1150, 2002.
Hawkins D S, Rajendran J G, Conrad E U, 3rd, Bruckner J D, and Eary J F. Evaluation of chemotherapy response in pediatric bone sarcomas by [F-18]-fluorodeoxy-D-glucose positron emission tomography. Cancer, 94: 3277–3284, 2002.
Murphey M D, Walker E A, Wilson A J, Kransdorf M J, Temple H T, and Gannon F H. From the archives of the AFIP: imaging of primary chondrosarcoma: radiologic-pathologic correlation. Radiographics, 23: 1245–1278, 2003.
Feldman F, Van Heertum R, Saxena C, and Parisien M. 18FDG-PET applications for cartilage neoplasms. Skeletal Radiol, 34: 367–374, 2005.
Murphey M D, Flemming D J, Boyea S R, Bojescul J A, Sweet D E, and Temple H T. Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features. Radiographics, 18: 1213–1237; quiz 1244–1215, 1998.
Lee F Y, Yu J, Chang S S, Fawwaz R, and Parisien M V. Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone. J Bone Joint Surg Am, 86-A: 2677–2685, 2004
Evans H L, Ayala A G, and Romsdahl M M. Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading. Cancer, 40: 818–831, 1977.
Arsos G, Venizelos I, Karatzas N, Koukoulidis A, and Karakatsanis C. Low-grade chondrosarcomas: a difficult target for radionuclide imaging. Case report and review of the literature. Eur J Radiol, 43: 66–72, 2002.
Tallini G, Dorfman H, Brys P, et al. Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumors. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group. J Pathol, 196: 194–203, 2002.
Janzen L, Logan P M, O’Connell J X, Connell D G, and Munk P L. Intramedullary chondroid tumors of bone: correlation of abnormal peritumoral marrow and soft tissue MRI signal with tumor type. Skeletal Radiol, 26: 100–106, 1997.
Geirnaerdt M J, Bloem J L, Eulderink F, Hogendoorn P C, and Taminiau A H. Cartilaginous tumors: correlation of gadolinium-enhanced MR imaging and histopathologic findings. Radiology, 186: 813–817, 1993.
Aoki J, Sone S, Fujioka F, et al. MRI of enchondroma and chondrosarcoma: rings and arcs of Gd-DTPA enhancement. J Comput Assist Tomogr, 15: 1011–1016, 1991.
Geirnaerdt M J, Hogendoorn P C, Bloem J L, Taminiau A H, and van der Woude H J. Cartilaginous tumors: fast contrast-enhanced MR imaging. Radiology, 214: 539–546, 2000.
Brenner W, Conrad E U, and Eary J F. FDG PET imaging for grading and prediction of outcome in chondrosarcoma patients. Eur J Nucl Med Mol Imaging, 31: 189–195, 2004.
Collins M S, Koyama T, Swee R G, and Inwards C Y. Clear cell chondrosarcoma: radiographic, computed tomographic, and magnetic resonance findings in 34 patients with pathologic correlation. Skeletal Radiol, 32: 687–694, 2003.
Kaim A H, Hugli R, Bonel H M, and Jundt G. Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation. Skeletal Radiol, 31: 88–95, 2002.
Davila J A, Amrami K K, Sundaram M, Adkins M C, and Unni K K. Chondroblastoma of the hands and feet. Skeletal Radiol, 33: 582–587, 2004.
Aoki J, Tanikawa H, Ishii K, et al. MRI findings indicative of hemosiderin in giant-cell tumor of bone: frequency, cause, and diagnostic significance. AJR Am J Roentgenol, 166: 145–148, 1996.
Kumta S M, Griffith J F, Chow L T, and Leung P C. Primary juxtacortical chondrosarcoma dedifferentiating after 20 years. Skeletal Radiol, 27: 569–573, 1998.
Schajowicz F. Juxtacortical chondrosarcoma. J Bone Joint Surg Br, 59-B: 473–480, 1977.
Robinson P, White L M, Sundaram M, et al. Periosteal chondroid tumors: radiologic evaluation with pathologic correlation. AJR Am J Roentgenol, 177: 1183–1188, 2001.
Seeger L L, Yao L, and Eckardt J J. Surface lesions of bone. Radiology, 206: 17–33, 1998.
Antonescu C R, Argani P, Erlandson R A, Healey J H, Ladanyi M, and Huvos A G. Skeletal and extraskeletal myxoid chondrosarcoma: a comparative clinicopathologic, ultrastructural, and molecular study. Cancer, 83: 1504–1521, 1998.
Amukotuwa S A, Choong P F, Smith P J, Powell G J, Thomas D, and Schlicht S M. Femoral mesenchymal chondrosarcoma with secondary aneurysmal bone cysts mimicking a small-cell osteosarcoma. Skeletal Radiol, 35: 311–318, 2006.
Nussbeck W, Neureiter D, Soder S, Inwards C, and Aigner T. Mesenchymal chondrosarcoma: an immunohistochemical study of 10 cases examining prognostic significance of proliferative activity and cellular differentiation. Pathology, 36: 230–233, 2004.
Chidambaram A and Sanville P. Mesenchymal chondrosarcoma of the maxilla. J Laryngol Otol, 114: 536–539, 2000.
Nguyen B D, Daffner R H, Dash N, Rothfus W E, Nathan G, and Toca A R, Jr. Case report 790. Mesenchymal chondrosarcoma of the sacrum. Skeletal Radiol, 22: 362–366, 1993.
Frassica F J, Unni K K, Beabout J W, and Sim F H. Dedifferentiated chondrosarcoma. A report of the clinicopathological features and treatment of seventy-eight cases. J Bone Joint Surg Am, 68: 1197–1205, 1986.
Staals E L, Bacchini P, and Bertoni F. Dedifferentiated central chondrosarcoma. Cancer, 106: 2682–2691, 2006.
Bruns J, Fiedler W, Werner M, and Delling G. Dedifferentiated chondrosarcoma–a fatal disease. J Cancer Res Clin Oncol, 131: 333–339, 2005.
Littrell L A, Wenger D E, Wold L E, et al. Radiographic, CT, and MR imaging features of dedifferentiated chondrosarcomas: a retrospective review of 174 de novo cases. Radiographics, 24: 1397–1409, 2004.
MacSweeney F, Darby A, and Saifuddin A. Dedifferentiated chondrosarcoma of the appendicular skeleton: MRI-pathological correlation. Skeletal Radiol, 32: 671–678, 2003.
Okada K, Hasegawa T, Tateishi U, Endo M, and Itoi E. Dedifferentiated chondrosarcoma with telangiectatic osteosarcoma-like features. J Clin Pathol, 59: 1200–1202, 2006.
Saifuddin A, Mann B S, Mahroof S, Pringle J A, Briggs T W, and Cannon S R. Dedifferentiated chondrosarcoma: use of MRI to guide needle biopsy. Clin Radiol, 59: 268–272, 2004.
Mulligan M E. Imaging techniques used in the diagnosis, staging, and follow-up of patients with myeloma. Acta Radiol, 46: 716–724, 2005.
Angtuaco E J, Fassas A B, Walker R, Sethi R, and Barlogie B. Multiple myeloma: clinical review and diagnostic imaging. Radiology, 231: 11–23, 2004.
Durie B G, Kyle R A, Belch A, et al. Myeloma management guidelines: a consensus report from the Scientific Advisors of the International Myeloma Foundation. Hematol J, 4: 379–398, 2003.
Vande Berg B C, Michaux L, Lecouvet F E, et al. Nonmyelomatous monoclonal gammopathy: correlation of bone marrow MR images with laboratory findings and spontaneous clinical outcome. Radiology, 202: 247–251, 1997.
Baur A, Stabler A, Nagel D, et al. Magnetic resonance imaging as a supplement for the clinical staging system of Durie and Salmon? Cancer, 95: 1334–1345, 2002.
Mulligan M E and Badros A Z. PET/CT and MR imaging in myeloma. Skeletal Radiol, 36: 5–16, 2007.
Johnston C, Brennan S, Ford S, and Eustace S. Whole body MR imaging: applications in oncology. Eur J Surg Oncol, 32: 239–246, 2006.
Lecouvet F E, Dechambre S, Malghem J, Ferrant A, Vande Berg B C, and Maldague B. Bone marrow transplantation in patients with multiple myeloma: prognostic significance of MR imaging. AJR Am J Roentgenol, 176: 91–96, 2001.
Ghanem N, Lohrmann C, Engelhardt M, et al. Whole-body MRI in the detection of bone marrow infiltration in patients with plasma cell neoplasms in comparison to the radiological skeletal survey. Eur Radiol, 16: 1005–1014, 2006.
Hartman R P, Sundaram M, Okuno S H, and Sim F H. Effect of granulocyte-stimulating factors on marrow of adult patients with musculoskeletal malignancies: incidence and MRI findings. AJR Am J Roentgenol, 183: 645–653, 2004.
Lecouvet F E, Vande Berg B C, Michaux L, et al. Stage III multiple myeloma: clinical and prognostic value of spinal bone marrow MR imaging. Radiology, 209: 653–660, 1998.
Layton K F, Thielen K R, Cloft H J, and Kallmes D F. Acute vertebral compression fractures in patients with multiple myeloma: evaluation of vertebral body edema patterns on MR imaging and the implications for vertebroplasty. AJNR Am J Neuroradiol, 27: 1732–1734, 2006.
Erly W K, Oh E S, and Outwater E K. The utility of in-phase/opposed-phase imaging in differentiating malignancy from acute benign compression fractures of the spine. AJNR Am J Neuroradiol, 27: 1183–1188, 2006.
Horger M, Claussen C D, Bross-Bach U, et al. Whole-body low-dose multidetector row-CT in the diagnosis of multiple myeloma: an alternative to conventional radiography. Eur J Radiol, 54: 289–297, 2005.
Nandurkar D, Kalff V, Turlakow A, Spencer A, Bailey M J, and Kelly M J. Focal MIBI uptake is a better indicator of active myeloma than diffuse uptake. Eur J Haematol, 76: 141–146, 2006.
Breyer R J, 3rd, Mulligan M E, Smith S E, Line B R, and Badros A Z. Comparison of imaging with FDG PET/CT with other imaging modalities in myeloma. Skeletal Radiol, 35: 632–640, 2006.
Nanni C, Zamagni E, Farsad M, et al. Role of 18F-FDG PET/CT in the assessment of bone involvement in newly diagnosed multiple myeloma: preliminary results. Eur J Nucl Med Mol Imaging, 33: 525–531, 2006.
Bredella M A, Steinbach L, Caputo G, Segall G, and Hawkins R. Value of FDG PET in the assessment of patients with multiple myeloma. AJR Am J Roentgenol, 184: 1199–1204, 2005.
Moulopoulos L A, Gika D, Anagnostopoulos A, et al. Prognostic significance of magnetic resonance imaging of bone marrow in previously untreated patients with multiple myeloma. Ann Oncol, 16: 1824–1828, 2005.
Ghanem N, Uhl M, Brink I, et al. Diagnostic value of MRI in comparison to scintigraphy, PET, MS-CT and PET/CT for the detection of metastases of bone. Eur J Radiol, 55: 41–55, 2005.
Roodman G D. Mechanisms of bone metastasis. N Engl J Med, 350: 1655–1664, 2004.
Hamaoka T, Madewell J E, Podoloff D A, Hortobagyi G N, and Ueno N T. Bone imaging in metastatic breast cancer. J Clin Oncol, 22: 2942–2953, 2004.
Schweitzer M E, Levine C, Mitchell D G, Gannon F H, and Gomella L G. Bull’s-eyes and halos: useful MRI discriminators of osseous metastases. Radiology, 188: 249–252, 1993.
Spuentrup E, Buecker A, Adam G, van Vaals J J, and Guenther R W. Diffusion-weighted MR imaging for differentiation of benign fracture edema and tumor infiltration of the vertebral body. AJR Am J Roentgenol, 176: 351–358, 2001.
Lauenstein T C, Goehde S C, Herborn C U, et al. Whole-body MR imaging: evaluation of patients for metastases. Radiology, 233: 139–148, 2004.
Schmidt G P, Haug A R, Schoenberg S O, and Reiser M F. Whole-body MRI and PET-CT in the management of cancer patients. Eur Radiol, 16: 1216–1225, 2006.
Fogelman I, Cook G, Israel O, and Van der Wall H. Positron emission tomography and bone metastases. Semin Nucl Med, 35: 135–142, 2005.
Nakamoto Y, Cohade C, Tatsumi M, Hammoud D, and Wahl R L. CT appearance of bone metastases detected with FDG PET as part of the same PET/CT examination. Radiology, 237: 627–634, 2005.
Rougraff B T, Kneisl J S, and Simon M A. Skeletal metastases of unknown origin. A prospective study of a diagnostic strategy. J Bone Joint Surg Am, 75: 1276–1281, 1993.
Mulligan M E, McRae G A, and Murphey M D. Imaging features of primary lymphoma of bone. AJR Am J Roentgenol, 173: 1691–1697, 1999.
Krishnan A, Shirkhoda A, Tehranzadeh J, Armin A R, Irwin R, and Les K. Primary bone lymphoma: radiographic-MR imaging correlation. Radiographics, 23: 1371–1383; discussion 1384–1377, 2003.
Mengiardi B, Honegger H, Hodler J, Exner U G, Csherhati M D, and Bruhlmann W. Primary lymphoma of bone: MRI and CT characteristics during and after successful treatment. AJR Am J Roentgenol, 184: 185–192, 2005.
Bernstein M, Kovar H, Paulussen M, et al. Ewing’s sarcoma family of tumors: current management. Oncologist, 11: 503–519, 2006.
Hatori M, Okada K, Nishida J, and Kokubun S. Periosteal Ewing’s sarcoma: radiological imaging and histological features. Arch Orthop Trauma Surg, 121: 594–597, 2001.
Ilaslan H, Sundaram M, Unni K K, and Dekutoski M B. Primary Ewing’s sarcoma of the vertebral column. Skeletal Radiol, 33: 506–513, 2004.
Li W Y, Brock P, and Saunders D E. Imaging characteristics of primary cranial Ewing sarcoma. Pediatr Radiol, 35: 612–618, 2005.
Brisse H, Ollivier L, Edeline V, et al. Imaging of malignant tumours of the long bones in children: monitoring response to neoadjuvant chemotherapy and preoperative assessment. Pediatr Radiol, 34: 595–605, 2004.
Furth C, Amthauer H, Denecke T, Ruf J, Henze G, and Gutberlet M. Impact of whole-body MRI and FDG-PET on staging and assessment of therapy response in a patient with Ewing sarcoma. Pediatr Blood Cancer, 47: 607–611, 2006.
Daldrup-Link H E, Franzius C, Link T M, et al. Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET. AJR Am J Roentgenol, 177: 229–236, 2001.
Hawkins D S, Schuetze S M, Butrynski J E, et al. [18F]Fluorodeoxyglucose positron emission tomography predicts outcome for Ewing sarcoma family of tumors. J Clin Oncol, 23: 8828–8834, 2005.
Dyke J P, Panicek D M, Healey J H, et al. Osteogenic and Ewing sarcomas: estimation of necrotic fraction during induction chemotherapy with dynamic contrast-enhanced MR imaging. Radiology, 228: 271–278, 2003.
Choi J J, Davis K W, and Blankenbaker D G. Percutaneous musculoskeletal biopsy. Semin Roentgenol, 39: 114–128, 2004.
Ogilvie C M, Torbert J T, Finstein J L, Fox E J, and Lackman R D. Clinical utility of percutaneous biopsies of musculoskeletal tumors. Clin Orthop Relat Res, 450: 95–100, 2006.
Puri A, Shingade V U, Agarwal M G, et al. CT-guided percutaneous core needle biopsy in deep seated musculoskeletal lesions: a prospective study of 128 cases. Skeletal Radiol, 35: 138–143, 2006.
Jelinek J S, Murphey M D, Welker J A, et al. Diagnosis of primary bone tumors with image-guided percutaneous biopsy: experience with 110 tumors. Radiology, 223: 731–737, 2002.
Mitsuyoshi G, Naito N, Kawai A, et al. Accurate diagnosis of musculoskeletal lesions by core needle biopsy. J Surg Oncol, 94: 21–27, 2006.
Anderson M W, Temple H T, Dussault R G, and Kaplan P A. Compartmental anatomy: relevance to staging and biopsy of musculoskeletal tumors. AJR Am J Roentgenol, 173: 1663–1671, 1999.
Liu P T, Valadez S D, Chivers F S, Roberts C C, and Beauchamp C P. Anatomically based guidelines for core needle biopsy of bone tumors: implications for limb-sparing surgery. Radiographics, 27: 189–205; discussion 206, 2007.
Mankin H J, Mankin C J, and Simon M A. The hazards of the biopsy, revisited. Members of the Musculoskeletal Tumor Society. J Bone Joint Surg Am, 78: 656–663, 1996.
Davies N M, Livesley P J, and Cannon S R. Recurrence of an osteosarcoma in a needle biopsy track. J Bone Joint Surg Br, 75: 977–978, 1993.
Hau A, Kim I, Kattapuram S, et al. Accuracy of CT-guided biopsies in 359 patients with musculoskeletal lesions. Skeletal Radiol, 31: 349–353, 2002.
Leffler S G and Chew F S. CT-guided percutaneous biopsy of sclerotic bone lesions: diagnostic yield and accuracy. AJR Am J Roentgenol, 172: 1389–1392, 1999.
Stoker D J, Cobb J P, and Pringle J A. Needle biopsy of musculoskeletal lesions. A review of 208 procedures. J Bone Joint Surg Br, 73: 498–500, 1991.
Tsukushi S, Katagiri H, Nakashima H, Shido Y, and Arai E. Application and utility of computed tomography-guided needle biopsy with musculoskeletal lesions. J Orthop Sci, 9: 122–125, 2004.
Saifuddin A, Mitchell R, Burnett S J, Sandison A, and Pringle J A. Ultrasound-guided needle biopsy of primary bone tumours. J Bone Joint Surg Br, 82: 50–54, 2000.
Yao L, Nelson S D, Seeger L L, Eckardt J J, and Eilber F R. Primary musculoskeletal neoplasms: effectiveness of core-needle biopsy. Radiology, 212: 682–686, 1999.
Goetz M P, Callstrom M R, Charboneau J W, et al. Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: a multicenter study. J Clin Oncol, 22: 300–306, 2004.
Callstrom M R, Charboneau J W, Goetz M P, et al. Painful metastases involving bone: feasibility of percutaneous CT- and US-guided radio-frequency ablation. Radiology, 224: 87–97, 2002.
Callstrom M R, Atwell T D, Charboneau J W, et al. Painful metastases involving bone: percutaneous image-guided cryoablation–prospective trial interim analysis. Radiology, 241: 572–580, 2006.
Roberts C C, Morrison W B, Deely D M, Zoga A C, Koulouris G, and Winalski C S. Use of a novel percutaneous biopsy localization device: initial musculoskeletal experience. Skeletal Radiol, 36: 53–57, 2007.
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Pahade, J., Sekhar, A., Shetty, S.K. (2008). Imaging of Malignant Skeletal Tumors. In: Blake, M.A., Kalra, M.K. (eds) Imaging in Oncology. Cancer Treatment and Research, vol 143. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-75587-8_15
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