Abstract
Recombinant human proteins produced by the mammary glands of genetically modified transgenic livestock mammals represent a special aspect of milk bioactive components. For therapeutic applications, the often complex posttranslational modifications of human proteins should be recapitulated in the recombinant products. Compared to alternative production methods, mammary gland production is a viable option, underlined by a number of transgenic livestock animal models producing abundant biologically active foreign proteins in their milk. Recombinant proteins isolated from milk have reached different phases of clinical trials, with the first marketing approval for human therapeutic applications from the EMEA achieved in 2006.
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Keywords
- Mammary Gland
- Cystic Fibrosis Transmembrane Conductance Regulator
- Livestock Species
- Whey Acidic Protein
- Human Lactoferrin
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Bösze, Z., Baranyi, M., Bruce, C., Whitelaw, A. (2008). Producing Recombinant Human Milk Proteins in the Milk of Livestock Species. In: Bösze, Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology, vol 606. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74087-4_15
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