Abstract
The lung is a complex organ composed of many different cell types. Its architecture is difficult to dissect so that a researcher can analyze specific pathways and early lesions. Animal models afford the opportunity for investigators to experimentally manipulate a number of controlled variables such as strain of animal, environment, and the genome in order to investigate the molecular interactions involved in the pathogenesis of many lung diseases.1 They also provide a unique opportunity to test potential therapeutic interventions. Transgenic mouse technology has provided a powerful tool for both neoplastic and noneoplastic disease investigation. Although the basic molecular biology terminology is covered in the first two chapters of this book, it is convenient to briefly review it here regarding the development of transgenic mice.
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Keywords
- Chronic Obstructive Pulmonary Disease
- Malignant Mesothelioma
- Emphysematous Change
- rasH2 Mouse
- Human Malignant Mesothelioma
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Barrios, R. (2008). Animal Models of Lung Disease. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_14
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DOI: https://doi.org/10.1007/978-0-387-72430-0_14
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