Abstract
The formation of the neural crest has been traditionally considered a classic example of secondary induction, where signals form one tissue elicit a response in a competent responding tissue. Interactions of the neural plate with paraxial mesoderm or nonneural ectoderm can generate neural crest. Several signaling pathways converge at the border between neural and nonneural ectoderm where the neural crest will form. Among the molecules identified in this process are members of the BMP, Wnt, FGF and Notch signaling pathways. The concerted action of these nals and their downstream targets will define the identity of the neural crest.
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
LeDouarin N. The neural crest: Cambridge University Press; 1982.
LeDouarin N, Kalcheim C. The Neural Crest. 2nd ed: Cambridge University Press; 1999.
Moury JD, Jacobson AG. The origins of neural crest cells in the axolotl. Dev Biol 1990;141(2):243–253.
Liem KF Jr, Tremml G, Roelink H et al. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 1995; 82(6):969–979.
Sclleck MA, Bronner-Fraser M. Origins of the avian neural crest: the role of neural plate-epidermal interactions. Development 1995; 121(2):525–538.
Mancilla A, Mayor R. Neural crest formation in Xenopus laevis: mechanisms of Xslug induction. Dev Biol 1996; 177(2):580–589.
Monsoro-Burq AH, Fletcher RB, Harland RM. Neural crest induction by paraxial mesoderm in Xenopus embryos requires FGF signals. Development 2003; 130(14):3111–3124.
LaBonne C, Bronner-Fraser M. Neural crest induction in Xenopus: evidence for a two-signal model. Development 1998; 125(13):2403–2414.
Rollhauser-ter Horst J. Artificial neural crest formation in amphibia. Anat Embryol (Berl) 1979; 157(1):113–120.
Rollhauser-ter Horst J. Neural crest replaced by gastrula ectoderm in amphibia. Effect on neurulation, CNS, gills and limbs. Anat Embryol (Berl) 1980; 160(2):203–211.
Woo K, Fraser SE. Specification of the hindbrain fate in the zebrafish. Dev Biol 1998; 197(2):283–296.
Dickinson ME, Selleck MA, McMahon AP et al. Dorsalization of the neural tube by the nonneural ectoderm. Development 1995; 121(7):2099–2106.
Hamburger V, Hamilton HL. A series of normal stages in the development of the chick embryo. J Morphol 1951; 88:49–92.
Basch ML, Selleck MA, Bronner-Fraser M. Timing and competence of neural crest formation. Dev Neurosci 2000; 22(3):217–227.
Raven CP, Kloos J. Induction by medial and lateral pieces of the archenteron roof with special reference to the determination of the neural crest. Acta Néerl Morph 1945; 5:348–362.
Marchant L, Linker C, Ruiz P et al. The inductive properties of mesoderm suggest that the neural crest cells are specified by a BMP gradient. Dev Biol 1998; 198(2):319–329.
Selleck MA, Bronner-Fraser M. The genesis of avian neural crest cells: a classic embryonic induction. Proc Natl Acad Sci USA 1996; 93(18):9352–9357.
Bonstein L, Elias S, Frank D. Paraxial-fated mesoderm is required for neural crest induction in Xenopus embryos. Dev Biol 1998; 193(2):156–168.
Bang AG, Papalopulu N, Kintner C et al. Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior nonaxial mesoderm. Development 1997; 124(10):2075–2085.
Ragland JW, Raible DW. Signals derived from the underlying mesoderm are dispensable for zebrafish neural crest induction. Dev Biol 2004; 276(1): 16–30.
Basler K, Edlund T, Jessell TM et al. Control of cell pattern in the neural tube: regulation of cell differentiation by dorsalin-1, a novel TGF beta family member. Cell 1993; 73(4):687–702.
Streit A, Lee KJ, Woo I et al. Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo. Development 1998; 125(3):507–519.
Selleck MA, Garcia-Castro MI, Artinger KB et al. Effects of Shh and Noggin on neural crest formation demonstrate that BMP is required in the neural tube but not ectoderm. Development 1998; 125(24):4919–4930.
Sela-Donenfeld D, Kalcheim C. Regulation of the onset of neural crest migration by coordinated activity of BMP4 and Noggin in the dorsal neural tube. Development 1999; 126(21):4749–4762.
Winnier G, Blessing M, Labosky PA, Hogan BL. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 1995; 9(17):2105–2116.
Dudley AT, Lyons KM, Robertson EJ. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 1995; 9(22):2795–2807.
Solloway MJ, Robertson EJ. Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 1999; 126(8):1753–1768.
McMahon JA, Takada S, Zimmerman LB et al. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev 1998; 12(10):1438–1452.
Matzuk MM, Lu N, Vogel H et al. Multiple defects and perinatal death in mice deficient in follistatin. Nature 1995; 374(6520):360–363.
Mayor R, Guerrero N, Martinez C. Role of FGF and noggin in neural crest induction. Dev Biol 1997; 189(1):1–12.
Nguyen VH, Trout J, Connors SA et al. Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. Development 2000; 127(6): 1209–1220.
Nguyen VH, Schmid B, Trout J et al. Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes. Dev Biol 1998; 199(1):93–110.
Schmid B, Furthauer M, Connors SA et al. Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development 2000; 127(5):957–967.
Nikaido M, Tada M, Saji T et al. Conservation of BMP signaling in zebrafish mesoderm patterning. Mech Dev 1997; 61(1–2):75–88.
Saint-Jeannet JP, He X, Varmus HE et al. Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a. Proc Natl Acad Sci USA 1997; 94(25):13713–13718.
Chang C, Hemmati-Brivanlou A. Neural crest induction by Xwnt7B in Xenopus. Dev Biol 1998; 194(1):129–134.
Garcia-Castro MI, Marcelle C, Bronner-Fraser M. Ectodermal Wnt function as a neural crest inducer. Science 2002; 297(5582):848–851.
Ikeya M, Lee SM, Johnson JE et al. Wnt signalling required for expansion of neural crest and CNS progenitors. Nature 1997; 389(6654):966–970.
Lee HY, Kleber M, Hari L et al. Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. Science 2004; 303(5660): 1020–1023.
Dickinson ME, Krumlauf R, McMahon AP. Evidence for a mikogenic effect of Wnt-1 in the developing mammalian central nervous system. Development 1994; 120(6):1453–1471.
Bang AG, Papalopulu N et al. Expression of Pax-3 in the lateral neural plate is dependent on a Wnt-mediated signal from posterior nonaxial mesoderm. Dev Biol 1999; 212(2):366–380.
Lewis JL, Bonner J, Modrell M et al. Reiterated Wnt signaling during zebrafish neural crest development. Development 2004; 131(6):1299–1308.
Villanueva S, Glavic A, Ruiz P et al. Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction. Dev Biol 2002; 241(2):289–301.
Glavic A, Silva F, Aybar MJ et al. Interplay between Notch signaling and the homeoprotein Xirol is required for neural crest induction in Xenopus embryos. Development 2004; 131(2):347–359.
Endo Y, Osumi N, Wakamatsu Y. Deltex/Dtx mediates NOTCH signaling in regulation of Bmp4 expression in cranial neural crest formation during avian development. Dev Growth Differ 2003; 45(3):241–248.
Endo Y, Osumi N, Wakamatsu Y. Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development. Development 2002; 129(4):863–873.
Cornell RA, Eisen JS. Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 function. Development 2002; 129(11):2639–2648.
Cornell RA, Eisen JS. Delta signaling mediates segregation of neural crest and spinal sensory neurons from zebrafish lateral neural plate. Development 2000; 127(13):2873–2882.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Landes Bioscience and Springer Science+Business Media
About this chapter
Cite this chapter
Basch, M.L., Bronner-Fraser, M. (2006). Neural Crest Inducing Signals. In: Saint-Jeannet, JP. (eds) Neural Crest Induction and Differentiation. Advances in Experimental Medicine and Biology, vol 589. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-46954-6_2
Download citation
DOI: https://doi.org/10.1007/978-0-387-46954-6_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-35136-0
Online ISBN: 978-0-387-46954-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)