Abstract
Development of the vertebrate skeleton is a complex process involving genes that control a series of cellular events such as proliferation, migration, mesenchymal condensations and eventually differentiation into osteoblasts and chondrocytes1. For osteoblast differentiation, an intricate and highly regulated interplay of growth factors, receptors/co-receptors, specific extracellular milieu and transcription factors is required2. Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF- ) superfamily, are multifunctional growth factors critically involved in osteoblast differentiation. The BMP functions are exerted through their interaction with specific cell surface receptors, BMP type I and II receptors, leading to the regulation of specific BMP target genes. The signaling is regulated at numerous steps at extracellular, cell surface and intracellular levels3, 4.
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Keywords
- Bone Morphogenetic Protein
- Osteoblast Differentiation
- C2C12 Cell
- Osteogenic Marker
- Sodium Dodecyl Sulfate Sample Buffer
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Mochida, Y., Parisuthiman, D., Yamauchi, M. (2006). Biglycan Is a Positive Modulator of BMP-2 Induced Osteoblast Differentiation. In: Fisher, J.P. (eds) Tissue Engineering. Advances in Experimental Medicine and Biology, vol 585. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34133-0_7
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DOI: https://doi.org/10.1007/978-0-387-34133-0_7
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