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Neuroprotective Effects of Estrogens

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Biology of Menopause

Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

Postmenopausal estrogen replacement therapy (ERT) is associated with numerous overall health benefits, including reduced risk of osteoporosis and a decrease in mortality (1). Of particular interest to neurodegenerative disease, ERT correlates with a decreased incidence of Alzheimer’s disease (AD) (2,3), reducing the onset of the disease by as much as 10 years in one study (3). Further, several small clinical studies support a role for estrogen therapy in improving cognitive function in AD patients (4–6). Epidemiological studies have also demonstrated a beneficial effect of ERT in reducing the mortality and morbidity associated with myocardial infarction and stroke in postmenopausal women (7–10).

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Authors
  1. James W. Simpkins
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  2. Pattie S. Green
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  3. Kelly E. Gridley
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  4. Jiong Shi
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  5. Eileen K. Monck
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Editor information

Editors and Affiliations

  1. Biology of Aging Program, National Institute on Aging, Gateway Building, Suite 2C231, 20892-9205, Bethesda, MD, USA

    Francis L. Bellino Ph.D.

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© 2000 Springer-Verlag New York, Inc.

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Simpkins, J.W., Green, P.S., Gridley, K.E., Shi, J., Monck, E.K. (2000). Neuroprotective Effects of Estrogens. In: Bellino, F.L. (eds) Biology of Menopause. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-0-387-21628-7_10

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  • DOI: https://doi.org/10.1007/978-0-387-21628-7_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-9530-0

  • Online ISBN: 978-0-387-21628-7

  • eBook Packages: Springer Book Archive

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