Abstract
The isothiazole ring as well as the corresponding benzo- and heterocondensed rings are present in many chemically interesting compounds. The isothiazole ring can be a substituent of a bioactive scaffold or the pharmacophore of bioactive molecules. New compounds have been designed, synthesised and tested towards different biological targets and, in many cases, they display interesting pharmaceutical activities. Different SAR studies are reported starting from already known isothiazole derivatives or from new compounds characterised by a particular substitution pattern aiming to improve the biological activity. Agrochemical applications are also reported.
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Clerici F, Gelmi ML, Pellegrino S (2008) Comp Heterocycl Chem III, (in press)
Chapman RF, Peart BJ (1996) Comp Heterocycl Chem II 3:319
Kaberdin RV, Potkin VI (2002) Russ Chem Rev 71:673
Taubert K, Kraus S, Schulze B (2002) Sulf Rep 23:79
Taubert K, Siegemund A, Schulze B (2002) Sulf Rep 24:279
Hamad Elgazwy A-SS (2003) Tetrahedron 59:7445
Ager DJ, Pantaleone DP, Henderson SA, Katritzky AR, Prakash I, Walters DE (1998) Ang Chem Int Ed 37:1802
Adams A, Slask R (1956) Chem Ind 42:1232
Soledade M, Pedras C, Suchy M (2006) Bioorg Med Chem 14:714
Luyten I, De Winter H, Busson R, Lescrinier T, Creuven I, Durant F, Balzarini J, De Clercq E, Herdewijn P (1996) Helv Chim Acta 79:1462
Kang YK, Lee KS, Yoo KH, Shin KJ, Kim DC, Lee C-S, Kong JY, Kim DJ (2003) Bioorg Med Chem Lett 13:463
Khalaj A, Adibpour N, Shahverdi AR, Daneshtalab M (2004) E J Med Chem 39:699
Nádel A, Pálinkás J (2000) J Het Chem 37:1463
Ebert B, Mortensen M, Thompson SA, Kehler J, Wafford KA, Krogsgaard-Larsen P (2001) Bioorg Med Chem Lett 11:1573
Gütschow M, Pietsch M, Taubert K, Freysoldt THE, Schulze B (2003) Z Naturforsch B: Chem Sci 58:111
Lu Z, Raghavan S, Bohn J, Charest M, Stahlhut MW, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR (2003) Bioorg Med Chem Lett 13:1821
Bürli RW, Ge Y, White S, Baird EE, Touami SM, Taylor M, Kaizerman JA, Moser HE (2002) Bioorg Med Chem Lett 12:2591
Kaizerman JA, Gross MI, Ge Y, White S, Hu W, Duan J-X, Baird EE, Johnson KW, Tanaka RD, Moser HE, Bürli RW (2003) J Med Chem 46:3914
Matzen L, Engesgaard A, Ebert B, Didriksen M, Frølund B, Krogsgaard-Larsen P, Jaroszewski JW (1997) J Med Chem 40:520
Matzen L, Ebert B, Stensbøl TB, Frølund B, Jaroszewski JW, Krogsgaard-Larsen P (1997) Bioorg Med Chem 5:1569
Jørgensen CG, Clausen RP, Hansen KB, Bräuner-Osborne H, Nielsen B, Metzler BB, Kehler J, Krogsgaard-Larsen P, Madsen U (2007) Org Biomol Chem 5:463
Perronnet J, Taliani L, Girault P, Poittevin A (1976) US Patent 3983129
Varaprasad CVNS, Barawkar D, El Abdellaoui H, Chakravarty S, Allan M, Chen H, Zhang W, Wu JZ, Tam R, Hamatake R, Lang S, Hong Z (2006) Bioorg Med Chem Lett 16:3975
Larson G, Yan S, Chen H, Rong F, Hong Z, Wu JZ (2007) Bioorg Med Chem Lett 17:172
Yan S, Appleby T, Gunic E, Shim JE, Tasu T, Kim H, Rong F, Chen H, Hamatake R, Wu JZ, Hong Z, Yao N (2007) Bioorg Med Chem Lett 17:28
El Abdellaoui H, Varaprasad CVNS, Barawkar D, Chakravarty S, Maderna A, Tam R, Chen H, Allan M, Wu JZ, Appleby T, Yan S, Zhang W, Lang S, Yao N, Hamatake R, Hong Z (2006) Bioorg Med Chem Lett 16:5561
Cutri CCC, Garozzo A, Siracusa MA, Castro A, Tempera G, Sarva MC, Guerrera F (2002) Antiviral Res 55:357
Lipnicka U, Regiec A, Sulkowski E, Zimecki M (2006) Arch Pharm Chem Life Sci 339:401
Schieweck F, Tormo I Blasco J, Blettner C, Mueller B, Gewehr M, Grammenos W, Grote T, Gypser A, Rheinhimer J, Schaefer P, Schwoegler A, Wagner O, Rack M, Baumann E, Strathmann S, Schoefl U, Scherer M, Stierl R, Treacy MF, Culbertson DL, Bucci T (2005) WO Patent 2005040162
Watanabe Y, Yamazaki D, Otsu Y, Shibuya K (2003) WO Patent 2003051123
Samaritoni JG, Arndt L, Bruce TJ, Dripps JE, Gifford J, Hatton CJ, Hendrix WH, Schoonover JR, Johnson GW, Hegde VB, Thornburgh S (1997) J Agric Food Chem 45:1920
Samaritoni JG, Babcock JM, Schlenz ML, Johnson GW (1999) J Agric Food Chem 47:3381
Larson ER, Noe MC, Gant TG (1999) WO Patent 9962890
Lippa B, Morris J, Corbett M, Kwan TA, Noe MC, Snow SL, Gant TG, Mangiaracina M, Coffey HA, Foster B, Knauth EA, Wessel MD (2006) Bioorg Med Chem Lett 16:3444
Beebe JS, Jani JP, Knauth E, Goodwin P, Higdon C, Rossi AM, Emerson E, Finkelstein M, Floyd E, Harriman S, Atherton J, Hillerman S, Soderstrom C, Kou K, Gant T, Noe MC, Foster B, Rastinejad F, Marx MA, Schaeffer T, Whalen PM, Roberts WG (2003) Cancer Res 63:7301
Pedersen H, Bräuner-Osborne H, Ball RG, Frydenvang K, Meier E, Bøgesø KP, Krogsgaard-Larsen P (1999) Bioorg Med Chem 7:795
Marco JL, Ingate ST, Chinchòn PM (1999) Tetrahedron 55:7625
Dodge JA, Evers B, Jungheim LN, Muehl BS, Ruehter G, Thrasher KJ (2002) WO Patent 2002032888
Evers B, Ruehter G, Tebbe MJ, Martin de la Nava EM (2003) WO Patent 2003087069
Evers B, Ruehter G, Martin de la Nava EM, Tebbe MJ (2003) WO Patent 2003087070
Clerici F, Marazzi G, Taglietti M (1992) Tetrahedron 48:3227
Clerici F, Gelmi ML, Yokoyama K, Pocar D, Van Voorhis WC, Buckner FS, Gelb MH (2002) Bioorg Med Chem Lett 12:2217
Clerici F, Contini A, Corsini A, Ferri N, Grzesiak S, Pellegrino S, Sala A, Yokoyama K (2006) Eur J Med Chem 41:675
Clerici F, Erba E, Gelmi ML, Valle M (1997) Tetrahedron 53:15859
Beccalli EM, Clerici F, Gelmi ML (1999) Tetrahedron 55:2001
Clerici F, Contini A, Gelmi ML, Pocar D (2003) Tetrahedron 59:9399
Van Nhien AN, Tomassi C, Len C, Marco-Contelles JL, Balzarini J, Pannecouque C, De Clercq E, Postel D (2005) J Med Chem 48:4276
Alvarez R, Jimeno M-L, Gago F, Balzarini J, Perez-Perez M-J, Camarasa M-J (1998) Antiviral Chem Chemother 9:333
Marco JL, Ingate ST, Jaime C, Bea I (2000) Tetrahedron 56:2523
Evers B, Ruehter G, Berg M, Dodge JA, Hankotius D, Hary U, Jungheim LN, Mest H-J, de la Nava E-MM, Mohr M, Muehl BS, Petersen S, Sommer B, Riedel-Herold G, Tebbe MJ, Thrasher KJ, Voelkers S (2005) Bioorg Med Chem 13:6748
Subramanyam C, Bell MR, Ghose AK, Kumar V, Dunlap RP, Franke C, Mura AJ (1995) Bioorg Med Chem Lett 5:325
Kuang R, Epp JB, Ruan S, Chong LS, Venkataraman R, Tu J, He S, Truong TM, Groutas WC (2000) Bioorg Med Chem 8:1005
Kuang R, Venkataraman R, Ruan S, Groutas WC (1998) Bioorg Med Chem Lett 8:539
Yue EW, Wayland B, Douty B, Crawley ML, McLaughlin E, Takvorian A, Wasserman Z, Bower MJ, Wei M, Li Y, Ala PJ, Gonneville L, Wynn R, Burn TC, Liu PCC, Combs AP (2006) Bioorg Med Chem 14:5833
Combs AP, Zhu W, Crawley ML, Glass B, Polam P, Sparks RB, Modi D, Takvorian A, McLaughlin E, Yue EW, Wasserman Z, Bower M, Wei M, Rupar M, Ala P, Reid BM, Ellis D, Gonneville L, Emm T, Taylor N, Yeleswaram S, Li Y, Wynn R, Burn TC, Hollis G, Liu PCC, Metcalf B (2006) J Med Chem 49:3774
Greig IR, Tozer MJ, Wright PT (2001) Org Lett 3:369
Cherney RJ, Mo R, Meyer DT, Hardman KD, Liu R-Q, Covington MB, Qian M, Wasserman ZR, Christ DD, Trzaskos JM, Newton RC, Decicco CP (2004) J Med Chem 47:2981
Cherney RJ, King BW, Gilmore JL, Liu R-Q, Covington MB, Duan JJ-W, Decicco CP (2006) Bioorg Med Chem Lett 16:1028
Spaltenstein A, Almond MR, Bock WJ, Cleary DG, Furfine ES, Hazen RJ, Kazmierski WM, Salituro FG, Tung RD, Wright LL (2000) Bioorg Med Chem Lett 10:1159
Alcaraz L, Baxter A, Bent J, Bowers K, Braddock M, Cladingboel D, Donald D, Fagura M, Furber M, Laurent C, Lawson M, Mortimore M, McCormick M, Roberts N, Robertson M (2003) Bioorg Med Chem Lett 13:4043
Bakshi RK, Hong Q, Tang R, Kalyani RN, MacNeil T, Weinberg DH, Van der Ploeg LHT, Patchett AA, Nargund RP (2006) Bioorg Med Chem Lett 16:1130
Inagaki M, Tsuri T, Jyoyama H, Ono T, Yamada K, Kobayashi M, Hori Y, Arimura A, Yasui K, Ohno K, Kakudo S, Koizumi K, Suzuki R, Kato M, Kawai S, Matsumoto S (2000) J Med Chem 43:2040
Inagaki M, Haga N, Kobayashi M, Ohta N, Kamata S, Tsuri T (2002) J Org Chem 67:125
Valente C, Guedes RC, Moreira R, Iley J, Gut J, Rosenthal PJ (2006) Bioorg Med Chem Lett 16:4115
Singh SK, Reddy PG, Rao KS, Lohray BB, Misra P, Rajjak SA, Rao YK, Venkateswarlu A (2004) Bioorg Med Chem Lett 14:499
Dehmlow H, Aebi JD, Jolidon S, Ji Y-H, Von der Mark EM, Himber J, Morand OH (2003) J Med Chem 46:3354
Brown BS, Jinkerson TK, Keddy RG, Lee C-H (2006) WO Patent 2006065646
Vicini P, Zani F, Cozzini P, Doytchinova I (2002) Eur J Med Chem 37:553
Zani F, Vicini P, Incerti M (2004) Eur J Med Chem 39:135
Vicini P, Fisicaro E, Lugari MT (2000) Arch Pharm 333:135
Geronikaki A, Vicini P, Incerti M, Hadjipavlou-Litina D (2004) Arzneim Forsch 54:530
Vicini P, Incerti M, Amoretti L, Ballabeni V, Tognolini M, Barocelli E (2002) Farmaco 57:363
Morini G, Pozzoli C, Adami M, Poli E, Coruzzi G (1999) Farmaco 54:740
Sharma PK, Sawhney SN (1997) Bioorg Med Chem Lett 7:2427
Yevich JP, New JS, Smith DW, Lobeck GW, Catt JD, Minielli LJ, Eison MS, Taylor DP, Riblet LA, Temple DL (1986) J Med Chem 29:359
Su W, Chen Z, Lou F, Xu Y, Wang B (2006) CN Patent 1850811
Kraus H, Krebs A, Sollner R (1998) EU Patent 846692
Vicini P (1986) Farmaco 41:808
Böshagen H, Geiger W (1977) J Liebigs Ann Chem, p 20
Panico A, Vicini P, Incerti M, Cardile V, Gentile B, Ronsisvalle G (2002) Farmaco 57:671
Vicini P, Zani F (1997) Farmaco 52:21
Navas FIII, Tang FLM, Schaller LT, Norman MH (1998) Bioorg Med Chem 6:811
Ishizumi K, Kojima A, Antoku F, Saji I, Yoshigi MC (1995) Chem Pharm Bull 43:2139
Orjales A, Mosquera R, Toledo A, Pumar C, Labeaga L, Innerarity A (2002) Eur J Med Chem 37:721
Perrone R, Berardi F, Colabufo NA, Leopoldo M, Tortorella V (2000) Bioorg Med Chem 8:873
Orjales A, Mosquera R, Toledo A, Pumar MC, Garcia N, Cortizo L, Labeaga L, Innerarity A (2003) J Med Chem 46:5512
Zbigniew M, Rusin KE, Sawicki AW, Kurowski K, Matusiewicz KJ, Stawinski T, Sulikowski D, Ktudkiewicz DD (2006) US Patent 2006160870
Morini G, Pozzoli C, Menozzi A, Comini M, Poli E (2005) Farmaco 60:810
Xie W, Herbert B, Schumacher RA, Ma J, Nguyen TM, Gauss CM, Tehim A (2005) WO Patent 2005111038
López-Rodríguez ML, Porras E, Benhamú B, Ramos JA, Morcillo MJ, Lavandera JL (2000) Bioorg Med Chem Lett 10:1097
Wilkening RR, Ratcliffe RW, Wildonger KJ, Cama LD, Dykstra KD, DiNinno FP, Blizzard TA, Hammond ML, Heck JV, Dorso KL, St Rose E, Kohler J, Hammond GG (1999) Bioorg Med Chem Lett 9:673
Ratcliffe RW, Wilkening RR, Wildonger KJ, Waddell ST, Santorelli GM, Parker DL Jr, Morgan JD, Blizzard TA, Hammond ML, Heck JV, Huber J, Kohler J, Dorso KL, St Rose E, Sundelof JG, May WJ, Hammond GG (1999) Bioorg Med Chem Lett 9:679
Humphrey GR, Miller RA, Pye PJ, Rossen K, Reamer RA, Maliakal A, Ceglia SS, Grabowski EJJ, Volante RP, Reider PJ (1999) J Am Chem Soc 121:11261
Swayze EE, Drach JC, Wotring LL, Townsend LB (1997) J Med Chem 40:771
Zask A, Gu Y, Albright JD, Du X, Hogan M, Levin JI, Chen JM, Killar LM, Sung A, Di Joseph JF, Sharr MA, Roth CE, Skala S, Jin G, Cowling R, Mohler KM, Barone D, Black R, March C, Skotnicki JS (2003) Bioorg Med Chem Lett 13:1487
Desai RC, Dunlap RP, Farrell RP, Ferguson E, Franke CA, Gordon R, Hlasta DJ, Talomie TG (1995) Bioorg Med Chem Lett 5:105
Xu L, Shu H, Liu Y, Zhang S, Trudell ML (2006) Tetrahedron 62:7902
Nerenberg JB, Erb JM, Thompson WJ, Lee H-Y, Guare JP, Munson PM, Bergman JM, Huff JR, Broten TP, Chang RSL, Chen TB, O'Malley S, Schorn TW, Scott AL (1998) Bioorg Med Chem Lett 8:2467
Da Settimo F, Primofiore G, La Motta C, Sartini S, Taliani S, Simorini F, Marini AM, Lavecchia A, Novellino E, Boldrini E (2005) J Med Chem 48:6897
Nagasawa HT, Kawle SP, Elberling JA, DeMaster EG, Fukuto JM (1995) J Med Chem 38:1865
Groutas WC, Chong LS, Venkataraman R, Epp JB, Kuang R, Houser-Archield N, Hoidal JR (1995) Bioorg Med Chem 3:187
Carmellino ML, Pagani G, Terreni M, Pregnolato M, Borgna P, Pastoni F, Zani F (1997) Farmaco 52:359
Borgna P, Carmellino ML, Natangelo M, Pagani G, Pastoni F, Pregnolato M, Terreni M (1996) Eur J Med Chem 31:919
Fiore PJ, Puls TP, Walker JC (1998) Org Proc Res Dev 2:151
Turpin JA, Song Y, Inman JK, Huang M, Wallqvist A, Maynard A, Covell DG, Rice WG, Appella E (1999) J Med Chem 42:67
Borgna P, Pregnolato M, Invernizzi AG, Mellerio G (1993) J Het Chem 30:1079
Pagani G, Pregnolato M, Ubiali D, Terreni M, Piersimoni C, Scaglione F, Fraschini F, Rodríguez Gascón A, Pedraz Munoz JL (2000) J Med Chem 43:199
Pregnolato M, Borgnan P, Terreni M (1995) J Het Chem 32:847
Wright SW, Corbett RL (1993) Org Prep Proc Int 25:247
Wright SW, Petraitis JJ, Batt DG, Corbett RL, Di Meo SV, Freimark B, Giannaras JV, Orwat MJ, Pinto DJ, Pratta MA, Sherk SR, Stampfli HF, Williams JM, Magolda RL, Arner EC (1995) Bioorg Med Chem 3:227
Terauchi H, Tanitame A, Tada K, Nishikawa Y (1996) Heterocycles 43:1719
Wiles JA, Song Y, Wang Q, Lucien E, Hashimoto A, Cheng J, Marlor CW, Ou Y, Podos SD, Thanassi JA, Thoma LC, Deshpande M, Pucci MJ, Bradbury BJ (2006) Bioorg Med Chem Lett 16:1277
Wiles JA, Wang Q, Lucien E, Hashimoto A, Song Y, Cheng J, Marlor CW, Ou Y, Podos SD, Thanassi JA, Thoma LC, Deshpande M, Pucci MJ, Bradbury BJ (2006) Bioorg Med Chem Lett 16:1272
Hlasta DJ, Ackerman JH, Court JJ, Farrell RP, Johnson JA, Kofron JL, Robinson DT, Talomie TG, Dunlap RP, Franke CA (1995) J Med Chem 38:4687
Hlasta DJ, Subramanyam C, Bell MR, Carabateas PM, Court JJ, Desai RC, Drozd ML, Eickhoff WM, Ferguson EW, Gordon RJ, Dunlap RP, Franke CA, Mura AJ, Rowlands A, Johnson JA, Kumar V, Maycock AL, Mueller KR, Pagani ED, Robinson DT, Saindane MT, Silver PJ, Subramanian S (1995) J Med Chem 38:739
Guzel O, Salman A (2006) Biorg Med Chem 14:7804
Hlasta DJ, Bell MR, Court JJ, Cundy KC, Desai RC, Ferguson EW, Gordon RJ, Kumar V, Maycock AL, Subramanyam C (1995) Biorg Med Chem Lett 5:331
Combrink KD, Gülgeze HB, Meanwell NA, Pearce BC, Zulan P, Bisacchi GS, Roberts DGM, Stanley P, Seiler SM (1998) J Med Chem 41:4854
Yu K-L, Civiello R, Roberts DGM, Seiler SM, Meanwell NA (1999) Bioorg Med Chem Lett 9:663
Varga M, Kapui Z, Batori S, Nagy LT, Vasvari-Debreczy L, Mikus E, Urbán-Szabó K, Arányi P (2003) Eur J Med Chem 38:421
Desai RC, Court JC, Ferguson E, Gordon R, Hlasta DJ (1995) J Med Chem 38:1571
Groutas WC, Epp JB, Venkataraman R, Kuang R, Truong TM, McClenahan JJ, Prakash O (1996) Biorg Med Chem 4:1393
Hartog J, Van Steen BJ, Mos J, Schipper J (1995) EU Patent 0633260
Van Steen BJ, Van Wijngaarden I, Ronken E, Soudijn W (1998) Bioorg Med Chem Lett 8:2457
Caliendo G, Fiorino F, Perissutti E, Severino B, Scolaro D, Gessi S, Cattabriga E, Borea PA, Santagada V (2002) Eur J Pharm Sci 16:15
Gross JL (2003) Tetrahedron Lett 44:8563
Patane MA, Di Pardo RM, Price RAP, Chang RSL, Ransom RW, O'Malley SS, Di Salvo J, Bock MG (1998) Bioorg Med Chem Lett 8:2495
Zlatkov A, Peikov P, Rodriguez-Alvarez J, Danchev N, Nikolova I, Mitkov J (2000) Eur J Med Chem 35:941
Primofiore G, Da Settimo F, La Motta C, Simorini F, Minutolo A, Boldrini E (1997) Farmaco 52:583
Da Settimo A, Primofiore G, La Motta C, Da Settimo F, Simorini F, Boldrini E, Bianchini P (1996) Farmaco 51:261
Aal EHA, El-Sabbagh OI, Youssif S, El-Nabtity (2002) Monats Chem 133:255
Scherling D, Karl W, Seidel D, Weinz C, Schohe-loop R, Mauler F (2003) WO Patent 2003029250
Malinka W, Sieklucka-Dziuba M, Rajtar G, Zgodzinski W, Kleinrok Z (2000) Pharmazie 6:416
Malinka W, Swiatek P, Flipek B, Sapa J, Jezierska A, Koll A (2005) Farmaco 60:961
Malinka W, Sieklucka-Dziuba M, Rajtar G, Marowska D, Kleinrok Z (1995) Farmaco 50:769
Malinka W, Rutkowska M (1997) Farmaco 52:595
Malinka W, Ryng S, Sieklucka-Dziuba M, Rajtar G, Głowniak A, Kleinrok Z (1998) Farmaco 53:504
Bradbury BJ, Pais G, Wang Q, Deshpande M, Pucci MJ, Song Y, Lucien E, Wiles JA, Hashimoto A (2006) WO Patent 2006089054
Singerman GM (1976) US Patent 3997548
Ikeda K, Abe N, Katoh C, Kanaoka A (1994) EU Patent 578246
Davis RH, Krummel G (1994) EU Patent 623282
Pilkington BL, Armstrong S, Barnes NJ, Barnett SP, Clarke ED, Crowley PJ, Fraser TEM, Hughes D, Methews CJ, Salmon R, Smith SC, Viner R, Whittingham WG, Williams J, Whittle AJ, Mound WR, Urch CJ (2001) WO Patent 2001090105
Watanabe Y, Yamazaki D, Otsu Y, Shibuya K (2003) (2003) WO 2003051123
Morley JO, Oliver AJ, Charlton MH (1998) J Mol Struct 429:103
Alvarez-Sanchez R, Basketter D, Pease C, Lepoittevin J-P (2004) Bioorg Med Chem Lett 14:365
Zani F, Pregnolato M, Zampollo F (1999) Farmaco 54:643
Chu DTW, Fernandes PB, Claiborne AK, Shen L, Pernet AG (1988) Drugs Exp Clin Res 14:379
Pagani G, Borgna P, Piersimoni C, Nista D, Terreni M, Pregnolato M (1996) Arch Pharm 329:421
Wang Q, Lucien E, Hashimoto A, Pais GCG, Nelson DM, Song Y, Thanassi JA, Marlor CW, Thoma CL, Cheng J, Podos SD, Ou Y, Deshpande M, Pucci MJ, Buechter DD, Bradbury BJ, Wiles JA (2007) J Med Chem 50:199
Yasuda N, Yang C, Wells KM, Jensen MS, Hughes DL (1999) Tetrahedron Lett 40:427
Soriano E, Marco-Contelles J, Tomassi C, Van Nhien AN, Postel D (2006) J Chem Inf Model 46:1666
Cutri CCC, Garozzo A, Siracusa MA, Sarva MC, Tempera G, Geremia E, Pinizzotto MR, Guerrera F (1998) Biorg Med Chem 6:2271
Cutri CCC, Garozzo A, Siracusa MA, Sarva MC, Castro A, Geremia E, Pinizzotto MR, Guerrera F (1999) Biorg Med Chem 7:225
Ferri N, Clerici F, Yokoyama K, Pocar D, Corsini A (2005) Biochem Pharmacol 70:1735
Yan S, Appleby T, Gunic E, Shim JE, Tasu T, Kim H, Rong F, Chen H, Hamatake R, Wu JZ, Hong Z, Yao N (2007) Bioorg Med Chem Lett 17:28
Combs AP, Yue EW, Bower M, Ala PJ, Wayland B, Douty B, Takvorian A, Polam P, Wasserman Z, Zhu W, Crawley ML, Pruitt J, Sparks R, Glass B, Modi D, McLaughlin E, Bostrom L, Li M, Galya L, Blom K, Hillman M, Gonneville L, Reid BG, Wei M, Becker-Pasha M, Klabe R, Huber R, Li Y, Hollis G, Burn TC, Wynn R, Liu P, Metcalf B (2005) J Med Chem 48:6544
Yue EW, Wayland B, Douty B, Crawley ML, McLaughlin E, Takvorian A, Wasserman Z, Bower MJ, Wei M, Li Y (2006) Bioorg Medl Chem 14:5833
Brehm L, Ebert B, Kristiansen U, Wafford KA, Kemp JA, Krogsgaard-Larsen P (1997) Eur J Med Chem 32:357
Frolund B, Kristiansen U, Brehm L, Hansen AB, Krogsgaard-Larsen P, Falch E (1995) J Med Chem 38:3287
Ebert B, Mortensen M, Thompson SA, Kehler J, Wafford KA, Krogsgaard-Larsen P (2001) Bioorg Med Chem Lett 11:1573
Krogsgaard-Larsen P, Mikkelsen H, Jacobsen P, Falch E, Curtis DR, Peet MJ, Leah JD (1983) J Med Chem 26:895
Hermit MB, Greenwood JR, Nielsen B, Bunch L, Jorgensen CG, Vestergaard HT, Stensbol TB, Sanchez C, Krogsgaard-Larsen P, Madsen U, Brauner-Osborne H (2004) Eur J Pharm 486:241
Singer JM, Barr BM, Coughenour LL, Gregory TF, Walters MA (2005) Bioorg Med Chem Lett 15:4560
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Clerici, F., Gelmi, M.L., Pellegrino, S., Pocar, D. (2007). Chemistry of Biologically Active Isothiazoles. In: Khan, M.T.H. (eds) Bioactive Heterocycles III. Topics in Heterocyclic Chemistry, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2007_081
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