Abstract
A large number of drugs and biologically relevant molecules contain heterocyclic systems. Often the presence of hetero atoms or groupings imparts preferential specificities in their biological responses. Amongst the heterocyclic systems, thiazolidine is a biologically important scaffold known to be associated with several biological activities. Some of the prominent biological responses attributed to this skeleton are antiviral, antibacterial, antifungal, antihistaminic, hypoglycemic, anti-inflammatory activities. This diversity in the biological response profiles of thiazolidine has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. Many of these synthetic and biological explorations have been subsequently analyzed in detailed quantitative structure-activity relationship (QSAR) studies to correlate the respective structural features and physicochemical properties with the activities to identify the important structural components in deciding their activity behavior. In this, drugs or any biologically active molecules may be viewed as structural frames consisting of strategically positioned functional groups that will interact effectively with the complementary groups/sites of the receptor. With this in focus, the present article reviews the QSAR studies of diverse biological activities of the thiazolidines published during the past decade.
An erratum to this chapter is available at http://dx.doi.org/10.1007/7081_045.
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Abbreviations
- AF:
-
Aspergillus fumigatus
- AIDS:
-
acquired immune deficiency syndrome
- ANN:
-
artificial neural network
- AR:
-
aldose reductase
- ATPase:
-
adenosin tri-phosphatase
- BPN:
-
back propagation neural networks
- CA:
-
Candida albicans
- cAMP:
-
cyclic-adenosine mono phosphate
- CN:
-
Cryptococcus neoformans
- CODESSA:
-
comprehensive descriptors for structural and statistical analysis
- CoMFA:
-
comparative molecular field analysis
- CoMSIA:
-
comparative molecular similarity analysis
- COX:
-
cyclooxygenase
- CPE:
-
carrageenan mice paw edema
- CP-MLR:
-
combinatorial protocol in multiple linear regression
- E/L:
-
enzyme ligand interaction
- FA:
-
factor analysis
- G/PLS:
-
genetic partial least squares
- GAGs:
-
glycosaminoglycans
- GFA:
-
genetic function approximation
- HBTU:
-
2-(1H-benzotrizo-1-yl)-1,1,3,3-tetramethyluraniumhexafluorophospate
- HIV:
-
human immunodeficiency virus
- MEDV:
-
molecular electronegativity distance vector
- MFA:
-
molecular field analysis
- MLR:
-
multiple linear regression
- MMPs:
-
metalloproteinases
- MOE:
-
molecular operating environment
- MOPAC:
-
molecular orbital partial atomic charge
- MSA:
-
molecular shape analysis
- NNRTIs:
-
non-nucleoside reverse transcriptase inhibitors
- NO:
-
nitric oxide
- NPY5R:
-
neuropeptide Y5 receptor
- NRTIs:
-
nucleoside reverse transcriptase inhibitors
- NSAIDs:
-
non-steroidal anti-inflammatory drugs
- OA:
-
octopamine agonists
- PCR:
-
principle components regression
- PLS:
-
partial least square
- PPARs:
-
peroxisome proliferator-activated receptors
- QSAR:
-
quantitative structure-activity relationship
- RSM:
-
receptor surface model
- RT:
-
reverse transcriptase
- TM:
-
Tricophyton mentagrophyte
- TxA2:
-
Thromboxane A2
- TZDs:
-
thiazolidinediones
- VSMP:
-
variable selection and modeling method based on prediction
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Two of the authors (VRS and MKG) gratefully acknowledge CSIR, New Delhi, India for financial support in the form of a Senior Research Fellowship. CDRI communication no. 6894.
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Prabhakar, Y.S., Raja Solomon, V., Gupta, M.K., Katti, S.B. QSAR Studies on Thiazolidines: A Biologically Privileged Scaffold. In: Gupta, S.P. (eds) QSAR and Molecular Modeling Studies in Heterocyclic Drugs II. Topics in Heterocyclic Chemistry, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_021
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DOI: https://doi.org/10.1007/7081_021
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