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Biosynthesis of Prenylated Alkaloids Derived from Tryptophan

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Biosynthesis

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 209))

Abstract

The biosynthesis of prenylated indole alkaloids and related natural substances derived from tryptophan is reviewed. The families of compounds covered in this review include the brevianamides, austamides, paraherquamides, marcfortine, roquefortine, aszonalenin, echinulin, verruculogen, the fumitremorgins, a-cyclopiazonic acid, and the ergot alkaloids. Although other families of naturally occurring prenylated indole alkaloids exist, such as the iridoids, this review is intended to examine the biosynthesis of the groups selected based on their structural and biogenetic similarities. In addition, the biosynthesis of the families selected for this chapter have not, to the best of our knowledge, been previously reviewed.

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Authors and Affiliations

  1. Department of Chemistry, Colorado State University, Fort Collins, Colorado, 80523, USA

    Robert M. Williams, Emily M. Stocking & Juan F. Sanz-Cervera

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  1. Robert M. Williams
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  2. Emily M. Stocking
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  3. Juan F. Sanz-Cervera
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Editors and Affiliations

  1. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, Great Britain

    Finian J. Leeper

  2. Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada, T6G 2G2

    John C. Vederas

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Williams, R.M., Stocking, E.M., Sanz-Cervera, J.F. (2000). Biosynthesis of Prenylated Alkaloids Derived from Tryptophan. In: Leeper, F.J., Vederas, J.C. (eds) Biosynthesis. Topics in Current Chemistry, vol 209. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-48146-X_3

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