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References
Browns I, Robertson WB, Dixon HG (1967) The physiological response of the vessels of the placental bed to normal pregnancy. J Pathol Bacteriol 93:567–579
Pijneborg R, Bland JM, Robertson WB et al (1983) Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy. Placenta 4:397–413
Pijneborg R, Dixon G, Robertson WB et al (1980) Trophoblastic invasion of human decidua from 8–18 weeks of pregnancy. Placenta 1:3–19
Matijevic R, Meekins JW, Walkinshaw SA, Neilson JP, MacFadyen IR (1995) Spiral artery blood flow in the central and peripheral areas of the placental bed in the second trimester. Obstet Gynecol 86:289–292
Ramsey EM (1981) The story of spiral arteries. J Reprod Med 26:393
Reynolds SRM (1965) Physiology of the uterus, 2nd edn. Hafner, New York, p 329
Bieniarz J, Yoshida T, Romero-Salinas G et al (1969) Aortocaval compression by the uterus in late human pregnancy. IV Circulatory homeostasis by preferential perfusion of the placenta. Am J Obstet Gynecol 1034: 10–31
Pinjeborg R, Robertson WB, Brosens I et al (1981) Trophoblast invasion and the establishment of haemochorial placentation in man and laboratory animals. Placenta 2:71–92
Brown JCM, Veall N (1953) The maternal placental blood flow in normotensive and hypertensive women. J Obstet Gynaecol Br Emp 60:141–147
Dixon HG, Browne JCM, Davey D (1963) Choriodecidual and myometrial blood flow. Lancet 1:369–373
Maini CL, Rosati P, Galli G et al (1985) Noninvasive radioisotopic evaluation of placental blood flow. Gynecol Obstet Invest 19:196–206
Trudinger BJ, Giles WB, Cook CM (1985) Uteroplacental blood flow velocity-time waveforms in normal and complicated pregnancy. Br J Obstet Gynaecol 92:39–45
Schulman H, Fleischer A, Farmakides G et al (1986) Development of uterine artery compliance in pregnancy as detected by Doppler ultrasound. Am J Obstet Gynecol 155:1031–1036
Thaler I, Manor D, Itskovitz J et al (1990) Changes in uterine blood flow during human pregnancy. Am J Obstet Gynecol 162:121–125
Brosens I, Robertson WB, Dixon HG (1972) The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu 1:177
Khong TY, De Wolf F, Robertson WB et al (1986) Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol 93: 1049–1059
Robertson WB (1976) Uteroplacental vasculature. J Clin Pathol 29[Suppl 10]:9–17
Khong TY, Robertson WB (1992) Spiral artery disease. In: Coulam CB, Faulk WP, McIntyre JA (eds) Immunologic obstetrics. Norton, New York
Stirrat GM (1987) The immunology of hypertension in pregnancy. In: Sharp F, Symonds EM (eds) Hypertension in pregnancy. Perinatology Press, Ithaca, NY, p 249
Khong TY, Sawyer H, Heryet AR (1992) An immunohistologic study of endothelialization of uteroplacental vessels in human pregnancy: evidence that endothelium is focally disrupted by trophoblast in preeclampsia. Am J Obstet Gynecol 167:751–756
Sibai BM (1990) Preeclampsia-eclampsia. Curr Probl Obstet Gynecol Infertil 13:6
DeWolf F, Robertson WB, Brosens I (1975) The ultrastructure of acute atherosis in hypertensive pregnancy. Am J Obstet Gynecol 123:164–174
Lunell NO, Nylund L, Lewander R et al (1982) Uteroplacental blood flow in preeclampsia: measurements with indium-113 and a computer-linked gamma camera. Clin Exp Hypertens 11:105–117
Campbell S, Griffin DR, Pearce JMF et al (1983) New Doppler technique for assessing uteroplacental blood flow. Lancet 1:675–677
Fleischer A, Schulman H, Farmakides G et al (1986) Uterine artery Doppler velocimetry in pregnant women with hypertension. Am J Obstet Gynecol 154:806–813
Campbell S, Pearce JMF Hackett G et al (1986) Qualitative assessment of uteroplacental blood flow: early screening test for high risk pregnancies. Obstet Gynecol 68:649–653
Arduini D, Rizzo G, Romanini C et al (1987) Uteroplacental blood flow velocity waveforms as predictors of pregnancy-induced hypertension. Eur J Obstet Gynecol Reprod Biol 26:335–341
Voigt J, Becker V (1992) Uteroplacental insufficiency: comparison of uteroplacental blood flow velocimetry and histomorphology of placental bed. J Matern Fetal Invest 2:251–255
Aardema MW, Oosterhof H, Timmer A, Van Rooy I, Aarnoudse JG (2001) Uterine artery Doppler flow and uteroplacental vascular pathology in normal pregnancies and pregnancies complicated by preeclampsia and small for gestational age fetuses. Placenta 22:405–411
Lin S, Shimuzu I, Suehara N, Nakayama M, Aono T (1995) Uterine artery Doppler velocimetry in relation to trophoblast migration into the myometrium of the placental bed. Obstet Gynecol 85:760–765
Ness RB, Roberts JM (1996) Heterogeneous causes constituting the single syndrome of preeclampsia; a hypothesis and its implications. Am J Obstet Gynecol 175:1365–1370
Walters WAW, Lim YL (1975) Blood volume and haemodynamics in pregnancy. Clin Obstet Gynecol 2: 301–320
Christianson RE (1976) Studies of blood pressure during pregnancy. I. Influence of parity and age. Am J Obstet Gynecol 125:509–513
Clark SL, Cotton DB, Lee W et al (1989) Central hemodynamics of normal term pregnancy. Am J Obstet Gynecol 161:1439–1442
Weir RJ, Brown JJ, Fraser R et al (1975) Relationship between plasma renin, renin-substrate, angiotensin II, aldosterone and electrolytes in normal pregnancy. J Clin Endocrinol Metab 40:108–115
Tauffield PA, Mueller FB, Edersheim TG et al (1988) Blood pressure regulation in normal pregnancy: unmasking the role of renin angiotensin system with captopril (abstract). Clin Res 36:433A
Gant NF, Daley GL, Chand S et al (1973) A study of angiotensin II pressor response throughout primigravid pregnancy. J Clin Invest 52:2682–2689
Rosenfeld CR (1989) Changes in uterine blood flow during pregnancy. In: Rosenfeld CR (ed) The uterine circulation. Perinatology Press, Ithaca, NY, pp 135–156
Massicotte G, St Louis T, Parent A et al (1987) Decreased in vitro response to vasoconstrictors during pregnancy in normotensive and spontaneously hypertensive pregnant rats. Can J Physiol Pharmacol 65: 2466–2471
Naden RP, Rosenfeld CR (1981) Effect of angiotensin II on uterine and systemic vasculature in pregnant sheep. J Clin Invest 68:468–474
Moncada S, Gryglewski R, Bunting S et al (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibit platelet aggregation. Nature 263:663–665
Furchgott RF Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373–376
Furchgott RF, Vanhoutta PM (1989) Endothelium-derived relaxing and contracting factors. FASEB J 3: 2007–2018
Palmer RMJ, Ferrig AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524–526
Ignarro LJ (1989) Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res 65:1–21
Gardiner SM, Compton AM, Bennett T et al (1990) Control of regional blood flow by endothelium-derived nitric oxide. Hypertension 15:486–492
Ahokas RA, Sibai BM, Mabie MD et al (1988) Nifedipine does not adversely affect uteroplacental blood flow in the hypertensive term-pregnant rat. Am J Obstet Gynecol 159:1440–1445
Greiss FC (1966) Pressure-flow relationship in the gravid uterine vascular bed. Am J Obstet Gynecol 96: 41–47
Venuto RC, Cox JW, Stein JH et al (1976) The effect of changes in perfusion pressure on uteroplacental blood flow in the pregnant rabbit. J Chin Invest 57:938–944
Lindow SW, Davies N, Davey DA et al (1988) The effects of sublingual nifedipine on uteroplacental blood flow in hypertensive pregnancy. Br J Obstet Gynaecol 95:1276–1281
Thaler I, Weiner Z, Manor D et al (1991) Effect of calcium channel blocker nifedipine on uterine artery flow velocity waveforms. J Ultrasound Med 10:301–304
Landauer M, Phernetton TM, Parisi VM et al (1985) Ovine placental vascular response to the local application of prostacyclin. Am J Obstet Gynecol 151:460–464
Husslein P, Gitch E, Pateisky N et al (1985) Prostacyclin does not influence placental blood flow in vivo. Gynecol Obstet Invest 19:78–81
Speroff L, Haning RV Jr, Levin RM (1977) The effect of angiotensin II and indomethacin on uterine artery blood flow in pregnant monkey. Obstet Gynecol 50: 611–614
Weiner CP, Liu KZ, Thompson L et al (1991) Effect of pregnancy on endothelium and smooth muscle: their role in reduced adrenergic sensitivity. Am J Physiol 261:H1275–H1283
Ylikorkala O, Makila UM (1985) Prostacyclin and thromboxane in gynecology and obstetrics. Am J Obstet Gynecol 152:318–329
Magness RR, Osei-Boaten K, Mitchell MD et al (1985) In vitro prostacyclin production by ovine uterine and systemic arteries. J Chin Invest 76:2206–2212
Rakoczi I, Tihanyi K, Gero G et al (1988) Release of prostacyclin (PGIZ) from trophoblast in tissue culture: the effect of glucose concentration. Acta Physiol Hung 71:545–549
Diss EM, Gabbe GS, Moore JW et al (1992) Study of thromboxane and prostacyclin metabolism in an in vitro model of first-trimester human trophoblast. Am J Obstet Gynecol 167:1046–1052
Blumenstein M, Keelan JA, Mitchell MD (2001) Hypoxia attenuates PGE(2) but increases prostacyclin and thromboxane production in human term villous trophoblast. Placenta 22:519–525
Weiner CP, Martinez E, Chestnut DH et al (1989) Effect of pregnancy upon the uterine and carotid artery response to norepinephrine, epinephrine and phenylephrine in vessels with documented functional endothelium. Am J Obstet Gynecol 161:1605–1610
Resnik R, Killman AP, Barton MD et al (1976) The effect of various vasoactive compounds upon the uterine vascular bed. Am J Obstet Gynecol 125:201–206
Greiss FC Jr, Gabbe FL Jr, Anderson SG et al (1967) Effect of acetylcholine on the uterine vascular bed. Am J Obstet Gynecol 99:1073–1077
Van Buren GA, Yang D, Clark KE (1992) Estrogen induced uterine vasodilation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis. Am J Obstet Gynecol 167:828–833
Molnar M, Hertelendy F (1992) Nw-nitro-L-arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents. Am J Obstet Gynecol 166: 1560–1571
Luscher TF (1990) The endothelium: target and promoter of hypertension? Hypertension 15:482–485
Yanagisawa M, Kurihara H, Kimura S et al (1988) A novel potent vasoconstrictor-peptide produced by vascular endothelial cells. Nature 332:411–415
Katusie ZS, Vanhoutta PM (1989) Superoxide anion is an endothelium-derived contacting factor. Heart Circ Physiol 26:H33
Bodelsson G, Sjöberg NO, Stjernquist M (1992) Contactile effect of endothelium in human uterine artery and autoradiographic localization of its binding sites. Am J Obstet Gynecol 167:745–750
Svane D, Larsson B, Aim P et al (1993) Endothelia-1: immunocytochemistry, localization of binding sites, and contractile effects in human uteroplacental smooth muscle. Am J Obstet Gynecol 168:233–241
Taylor RN, Varma M, Nelson NHT et al (1990) Women with preeclampsia have higher plasma endothelia levels than women with normal pregnancies. J Chin Endocrinol Metab 71:1675–1677
Burns PN (1993) The physics of Doppler. In:Chervenak FA, Isaacson GC, Campbell S (eds) Ultrasound in obstetrics and gynecology. Little, Brown, Boston, pp 33–54
Thaler I, Bruck A (1991) Transvaginal sonography and Doppler measurements: physical considerations. In: Timor-Tritsch IE, Rottem S (eds) Transvaginal sonography. Elsevier, New York, pp 1–27
Thaler I, Manor D (1990) Transvaginal imaging: applied physical principles and terms. J Chin Ultrasound 18:235–238
Thaler I, Manor D, Rottem S et al (1990) Hemodynamic evaluation of the female pelvic vessels using a high-frequency ttansvaginal image-directed Doppler system. J Chin Ultrasound 18:364–369
Kurjak A, Jurkovic D, Alfirevic Z et al (1990) Transvaginal color Doppler imaging. J Chin Ultrasound 18:227–234
Thaler I, Manor D, Rottem S (1993) Transvaginal Doppler duplex system. In: Chervenak FA, Isaacson GC, Campbell S (eds) Ultrasound in obstetrics and gynecology. Little, Brown, Boston, pp 141–148
Bowere SJ, Campbell S (1993) Doppler velocimetry of the uterine artery as a screening test in pregnancy. In: Chervenak FA, Isaacson GC, Campbell S (eds) Ultrasound in obstetrics and gynecology. Little, Brown, Boston, pp 579–586
McCowan LM, Ritchie K, Mo LY et al (1988) Uterine artery flow velocity waveforms in normal and growth-retarded pregnancies. Am J Obstet Gynecol 158:499–504
Pearce JM, Campbell S, Cohen-Overbeek TE et al (1988) Reference ranges and sources of variation for indices used to characterize flow velocity waveforms obtained by duplex, pulsed Doppler ultrasound from the uteroplacental and fetal circulation. Br J Obstet Gynaecol 95:248–256
Hanretty KP, Primrose M, Neilson JP et al (1989) Pregnancy screening by Doppler uteroplacental and umbilical artery waveforms. Br J Obstet Gynaecol 96:1163–1167
Juaniaux E, Jurkovic D, Campbell S et al (1991) Investigation of the placental circulation by color Doppler. Am J Obstet Gynecol 164:486–488
Thaler I, Weiner Z, Itskovitz J (1992) Systolic and diastolic notch in uterine artery blood flow velocity waveforms in hypertensive pregnant patients: relationship to outcome. Obstet Gynecol 80:277–282
Bewley S, Campbell S, Cooper D (1989) Uteroplacental Doppler flow velocity waveforms in the second trimester: a complex circulation. Br J Obstet Gynaecol 90: 1040–1046
Deutinger J, Rudelstorfer R, Bernaschek G (1988) Vaginosonographic velocimetry of both uterine arteries by visual vessel recognition and pulsed Doppler method during pregnancy. Am J Obstet Gynecol 159:1072–1076
Konje JC, Kaufmann P, Bell SC, Taylor DJ (2001) A longitudinal study of the quantification of uterine blood volume flow using colour power angiography in appropriate for gestational age pregnancies. Am J Obstet Gynecol 185:608–613
Arduini D, Rizzo G, Romanini C (1991) Doppler ultrasonography in early pregnancy does not predict adverse pregnancy outcome. Ultrasound Obstet Gynecol 1:180–185
Jurkovic D, Jauniaux E, Kurjak A et al (1991) Transvaginal color Doppler assessment of uteroplacental blood flow in early pregnancy. Obstet Gynecol 77:365–369
Jaffe R, Warsof SL (1991) Transvaginal color Doppler imaging in the assessment of uteroplacental blood flow in normal first-trimester pregnancy. Am J Obstet Gynecol 164:781–785
Stabile I, Bilardo C, Panella M et al (1988) Doppler assessed uterine blood flow in the first trimester of pregnancy. Trophoblast Res 3:301–308
Den Ouden M, Cohen-Overbeek TE, Wladimiroff JW (1990) Uterine and fetal umbilical artery flow velocity waveforms in normal first trimester pregnancies. Br J Obstet Gynaecol 97:716–719
Stabile I, Grudzinskas J, Campbell S (1990) Doppler ultrasonographic evaluation of abnormal pregnancies in the first trimester. J Clin Ultrasound 18:497–501
Thaler I, Tessler M, Itskovitz J (1991) Systolic and diastolic notch in uterine artery FVW in the first trimester of pregnancy: clinical significance. Presented at the 4th Congress of the International Perinatal Doppler Society, Malmo
Alfirevic Z, Kurjak A (1990) Transvaginal colour Doppler ultrasound in normal and abnormal early pregnancy. J Perinat Med 18:173–180
Makikallio K, Tekay A, Jouppila P (2001) Effects of bleeding on uteroplacental, umbilicoplacental and yolksac hemodynamics in early pregnancy. Ultrasound Obstet Gynecol 18:352–356
Kurjak A, Zalud I, Predanic M, Kupesic S (1994) Transvaginal color and pulsed Doppler study of uterine blood flow in the first and early second trimesters of pregnancy: normal versus abnormal. J Ultrasound Med 13: 43–47
Pellizzari P, Pozzan C, Marchiory S, Zen T, Gangemi M (2002) Assessment of uterine artery blood flow in normal first-trimester pregnancies and in those complicated by uterine bleeding. Ultrasound Obstet Gynecol 19: 366–370
Jauniaux E, Zaidi J, Jurkovic D, Campbell S, Hustin J (1994) Comparison of colour Doppler features and pathological findings in complicated early pregnancy. Hum Reprod 9:2432–2437
Coppens M, Loquet P, Kollen M, De Neubourg F, Buytaert P (1996) Longitudinal evaluation of uteroplacental and umbilical blood flow changes in normal early pregnancy. Ultrasound Obstet Gynecol 7:114–121
Jaffe R, Jauniaux E, Hustin J (1997) Maternal circulation in the first-trimester human placenta — myth or reality? Am J Obstet Gynecol 176:695–705
Simpson NA, Nimrod C, De Vermette R, Fournier J (1997) Determination of intervillous flow in early pregnancy. Placenta 18:287–293
Simpson NA, Nimrod C, De Vermette R, Leblanc C, Fournier J (1998) Sonographic evaluation of intervillous flow in early pregnancy: use of echo-enhancement agents. Ultrasound Obstet Gynecol 11:204–208
Kurjak A, Kupesic S (1998) Parallel Doppler assessment of yolk sac and intervillous circulation in normal pregnancy and missed abortion. Placenta 19:619–623
Bude RO, van de Ven CJ, Rubin JM (1999) Transabdominal power Doppler sonography of the normal early placenta. Can Assoc Radiol J 50:255–259
Alouini S, Carbillon L, Perrot N, Uzan S, Uzan M (2002) Intervillous and spiral artery flows in normal pregnancies between 5 and 10 weeks of amenorrhea using color Doppler ultrasonography. Fetal Diagn Ther 17: 163–166
Jauniaux E, Hempstock J, Greenwold N, Burton GJ (2003) Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol 162:115–125
Giacobbe M, Zeferino LC, Franzin CM, Faundes A (2002) Uteroplacental circulation during the first trimester of normal and abnormal pregnancy. Reprod Biomed Online 4:62–67
Chesley LC (1978) Hypertensive disorders in pregnancy. Appleton-Century-Crofts, Norwalk, CT, p 225
Turnbull AC (1987) Maternal mortality and present trends. In: Sharp F, Symonds EM (eds) Hypertension in pregnancy. Perinatology Press, Ithaca, NY, p 135
MacGillivray I (1983) Preeclampsia: the hypertensive disease of pregnancy. Saunders, Philadelphia, p 17
Chiswick ML (1985) Intrauterine growth retardation. BMJ 291:845–848
Allen MC (1984) Developmental outcome and follow-up of the small for gestational age infant. Semin Perinatol 8:123–156
Resnik R (1978) Maternal disease with abnormal, fetal growth. J Reprod Med 21:315
Beaufils M, Uzan S, Donsimoni R et al (1985) Prevention of preeclampsia by early antiplatelet therapy. Lancet 1:840–842
Andersen HG, Andersen LF, Fuchs AR (1989) Diet, preeclampsia and intrauterine growth retardation. Lancet 1:1146
Kaar K, Jouppila P, Kuikka J et al (1980) Intervillous blood flow in normal and complicated late pregnancy measured by means of an intravenous 133Xe method. Acta Obstet Gynecol Scand 59:7–10
Nylund L, Lunell NO, Lewander R et al (1983) Uteroplacental blood flow index in intrauterine growth retardation of fetal and maternal origin. Br J Obstet Gynaecol 90:16–20
Sheppard BL, Bonnar J (1976) The ultrastructure of the arterial supply of the human placenta in pregnancy complicated by fetal growth retardation. Br J Obstet Gynaecol 83:948–959
McFayden IR, Price AB, Geirsson RT (1986) The relation of birthweight to histological appearance in vessels of the placental bed. Br J Obstet Gynaecol 93:476–481
Newnham JP, Patterson LL, James IR et al (1990) An evaluation of the efficacy of Doppler flow velocity waveform analysis as a screening test in pregnancy. Am J Obstet Gynecol 162:403–410
Jacobson S-L, Imhof R, Manning N et al (1990) The value of Doppler assessment of the uteroplacental circulation in predicting preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 162:110–114
Steel SA, Pearce JM, McFarland P et al (1990) Early Doppler ultrasound screening in prediction of hypertensive disorders of pregnancy. Lancet 1:1548–1551
Bewley S, Cooper D, Campbell S (1991) Doppler investigation of uteroplacental blood flow resistance in the second trimester: a screening study for preeclampsia and intrauterine growth retardation. Br J Obstet Gynaecol 98: 871–879
Zimmermann P, Eirio V, Koskinen J, Kujansuu E, Harrington K (1997) Doppler assessment of the uterine and uteroplacental circulation in the second trimester in pregnancies at risk for pre-eclampsia and/or intrauterine growth retardation: comparison and correlation between different Doppler parameters. Ultrasound Obstet Gynecol 9: 330–338
Papageorghiou AT, Yu CKH, Bindra R, Pandis G, Nicolaides KH (2001) Multicenter screening for preeclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation. Ultrasound Obstet Gynecol 18:441–449
Chien PF, Arnott N, Gordon A, Owen P, Khan SK (2000) How useful is uterine artery Doppler flow velocimetry in the prediction of preeclampsia, intrauterine growth retardation and perinatal death? An overview. Br J Obstet Gynaecol 107:196–208
Martin A, Bindra R, Curcio P, Cicero S, Nicolaides KH (2001) Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler at 11-14 weeks of gestation. Ultrasound Obstet Gynecol 18:583–586
Schuchter K, Metzenbauer M, Hafner E, Philipp K (2001) Uterine artery Doppler and placental volume in the first trimester in the prediction of pregnancy complications. Ultrasound Obstet Gynecol 18:590–592
Gant NF, Worley RJ (1980) Hypertension in pregnancy. Appleton-Lange, Norfolk, CT, p 29
Zeeman GC, Dekker GA (1992) Pathogenesis of preeclampsia: a hypothesis. Chr Obstet Gynecol 35:317
Thaler I, Manor D, Brandes JM et al (1990) Basic principles and clinical applications of the transvaginal Doppler duplex system in reproductive medicine. J In Vitro Fertil Embryo Transfer 7:74
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Thaler, I., Amit, A. (2005). Doppler Velocimetry of the Uteroplacental Circulation During Early Pregnancy. In: Maulik, D. (eds) Doppler Ultrasound in Obstetrics and Gynecology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-28903-8_17
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