Summary
Although the effects of cerebral ischemia on the blood-brain barrier have been extensively studied, the effects on the blood-cerebrospinal fluid barrier (BCSFB) at the choroid plexuses have received much less attention. This paper reviews evidence on the effects of cerebral ischemia on the choroid plexus, particularly focusing on the degree of blood flow reduction required to damage the lateral ventricle choroid plexuses during transient forebrain ischemia, and whether disruption of the BCSFB might affect nearby tissues.
Studies have shown that 2 common models of forebrain ischemia (4-vessel and 2-vessel with hypotension) cause damage to the lateral ventricle choroid plexus via necrosis and apoptosis. We have found that bilateral common carotid artery occlusion with hypotension causes an 87% reduction in lateral ventricle choroid plexus blood flow during ischemia and an approximate tripling of the permeability of the BCSFB to inulin after 6 hours of reperfusion. Interestingly, evidence suggests that this disruption of the BCSFB rather than disruption to the blood-brain barrier is the major cause of enhanced inulin entry into the hippocampus. The hippocampus undergoes selective delayed neuronal loss in that model of forebrain ischemia and the BCSFB disruption may participate in or modulate that delayed injury.
Access provided by Autonomous University of Puebla. Download to read the full chapter text
Chapter PDF
Similar content being viewed by others
References
Dienel GA (1984) Regional accumulation of calcium in postischemic rat brain. J Neurochem 43: 913–925
Ennis SR, Keep RF (2005) The effects of cerebral ischemia on the rat choroid plexus. J Cereb Blood Flow Metab [in press]
Ferrand-Drake M, Wieloch T (1999) The time-course of DNA fragmentation in the choroid plexus and the CA1 region following transient global ischemia in the rat brain. The effect of intraischemic hypothermia. Neuroscience 93: 537–549
Ikeda J, Mies G, Nowak TS, Joo F, Klatzo I (1992) Evidence for increased calcium influx across the choroid plexus following brief ischemia of gerbil brain. Neurosci Lett 142: 257–259
Johanson CE, Palm DE, Primiano MJ, McMillan PN, Chan P, Knuckey NW, Stopa EG (2000) Choroid plexus recovery after transient forebrain ischemia: role of growth factors and other repair mechanisms. Cell Mol Neurobiol 20: 197–216
Keep RF, Xiang J, Ennis SR (2005) The blood-CSF barrier and cerebral ischemia. In: Zheng W, Chodobski A (eds) The blood-cerebrospinal fluid barrier. Taylor & Francis, Boca Raton, pp 245–260
Kitagawa H, Setoguchi Y, Fukuchi Y, Mitsumoto Y, Koga N, Mori T, Abe K (1998) DNA fragmentation and HSP72 gene expression by adenovirus-mediated gene transfer in postischemic gerbil hippocampus and ventricle. Metab Brain Dis 13: 211–223
Liebeskind DS, Hurst RW (2004) Infarction of the choroid plexus. AJNR Am J Neuroradiol 25: 289–290
Pulsinelli WA, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491–498
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag
About this paper
Cite this paper
Ennis, S.R., Keep, R.F. (2006). Forebrain ischemia and the blood-cerebrospinal fluid barrier. In: Hoff, J.T., Keep, R.F., Xi, G., Hua, Y. (eds) Brain Edema XIII. Acta Neurochirurgica Supplementum, vol 96. Springer, Vienna. https://doi.org/10.1007/3-211-30714-1_59
Download citation
DOI: https://doi.org/10.1007/3-211-30714-1_59
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-30712-0
Online ISBN: 978-3-211-30714-4
eBook Packages: MedicineMedicine (R0)