Extending evidence-based medicine

The science of evidence-based medicine (EBM) is more than 20 years old. Unsurprisingly the movement has produced both an established orthodoxy and dissenting voices. This series of papers, whose authors include both ‘orthodox’ and ‘dissenting’ perspectives, considers how EBM might be extended beyond the epidemiological focus of its founding fathers. We invite comments from readers and anticipate that this series will provoke an important contemporary debate on what EBM is and what it should become.