Inflammation and Cardiometabolic Disease

The striking relationship between cardiovascular diseases and glucose metabolism imbalance has raised the likelihood that atherosclerosis and type 2 diabetes (T2DM) may share common antecedents. Inflammation is emerging as a plausible etiologic mechanism for both ailments. Both epidemiological and genetic studies indicate that increased pro-inflammatory biomarkers are associated with the development of insulin resistance, diabetes, and cardiovascular disease. Moreover, several constituents of the immune system present various degrees of inflammatory alterations in patients T2DM. Knowledge of the pathophysiological changes involved in the occurrence of T2DM and its related complications is critical for achieving a successful prevention, diagnosis and treatment. Genetic polymorphisms encoding production of inflammatory cytokines and increased level of inflammatory biomarkers are usually associated to chronic pathologic conditions in TDM2.The most apparent clinical changes are observed in the heart, the kidneys, the eyes, the adipose tissue, the liver, the pancreatic islets and the vasculature. In the "Inflammation and cardiometabolic diseases" collection of Cardiovascular Diabetology we will be happy to consider for publication original articles or reviews on diagnostic and therapeutic aspects related to this field, as well as on novel connected technologies.